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    TTI2 Tti2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853601, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TTI2
    Official Full Name
    Tti2p
    Primary source
    SGD:S000003897
    Locus tag
    YJR136C
    See related
    AllianceGenome:SGD:S000003897; FungiDB:YJR136C; VEuPathDB:YJR136C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in several processes, including cellular response to heat; cellular response to nutrient levels; and cellular response to salt stress. Located in cytoplasm. Part of TTT Hsp90 cochaperone complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TTI2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (677441..678706, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mcm22p Neighboring gene protein transporter TIM8 Neighboring gene sulfite reductase (NADPH) subunit beta Neighboring gene GTPase-activating protein IML1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic selection for mistranslation rescues a defective co-chaperone in yeast. Hoffman KS, et al. Nucleic Acids Res, 2017 Apr 7. PMID 27899648, Free PMC Article
    2. Acceptor Stem Differences Contribute to Species-Specific Use of Yeast and Human tRNA(Ser). Berg MD, et al. Genes (Basel), 2018 Dec 7. PMID 30544642, Free PMC Article
    3. Evolving Mistranslating tRNAs Through a Phenotypically Ambivalent Intermediate in Saccharomyces cerevisiae. Berg MD, et al. Genetics, 2017 Aug. PMID 28576863, Free PMC Article
    4. Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1. Genereaux J, et al. Genetics, 2012 Jul. PMID 22505622, Free PMC Article
    5. Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response. Hoffman KS, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172216, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to nutrient levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TTT Hsp90 cochaperone complex HDA PubMed 
    part_of TTT Hsp90 cochaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tti2p
    NP_012670.3
    • Subunit of the TTT complex and regulator of telomere length; subunit of the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; involved in the cellular stress response; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm; similar to S. pombe Tti2p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      677441..678706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181794.3 → NP_012670.3  TPA: Tti2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012670.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWV5, P47168
      UniProtKB/TrEMBL
      B3LQL9, B5VLS5, C7GM76, C8ZBT5, N1P1B2
      Conserved Domains (1) summary
      pfam10521
      Location:46 → 331
      Tti2; Tti2 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47168.1

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