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    SPP381 U4/U6-U5 snRNP complex subunit SPP381 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852449, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPP381
    Official Full Name
    U4/U6-U5 snRNP complex subunit SPP381
    Primary source
    SGD:S000000356
    Locus tag
    YBR152W
    See related
    AllianceGenome:SGD:S000000356; FungiDB:YBR152W; VEuPathDB:YBR152W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in generation of catalytic spliceosome for first transesterification step. Located in cytosol and nucleus. Part of U4/U6 x U5 tri-snRNP complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPP381 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (546376..547251)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Tbs1p Neighboring gene Apd1p Neighboring gene 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase Neighboring gene DNA-directed RNA polymerase core subunit RPB5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation. Lybarger S, et al. Mol Cell Biol, 1999 Jan. PMID 9858581, Free PMC Article
    2. Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability. Salas-Armenteros I, et al. Cell Rep, 2019 Aug 6. PMID 31390568, Free PMC Article
    3. Human MFAP1 is a cryptic ortholog of the Saccharomyces cerevisiae Spp381 splicing factor. Ulrich AK, et al. BMC Evol Biol, 2017 Mar 24. PMID 28335716, Free PMC Article
    4. Inhibition of a spliceosome turnover pathway suppresses splicing defects. Pandit S, et al. Proc Natl Acad Sci U S A, 2006 Sep 12. PMID 16945917, Free PMC Article
    5. Protein substrates of the arginine methyltransferase Hmt1 identified by proteome arrays. Low JK, et al. Proteomics, 2016 Feb. PMID 26572822

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in generation of catalytic spliceosome for first transesterification step IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6-U5 snRNP complex subunit SPP381
    NP_009710.3
    • mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia; temperature-sensitive phenotype of prp38-1 mutant can be suppressed by human homolog of SPP381, MFAP1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      546376..547251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178500.3 → NP_009710.3  TPA: U4/U6-U5 snRNP complex subunit SPP381 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009710.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQE7, P38282
      UniProtKB/TrEMBL
      B3LN07, D3UEP6, G2W9F4, N1P6S9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38282.1

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