Cdc14a CDC14 cell division cycle 14A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc14aprovided by MGI
Official Full Name: CDC14 cell division cycle 14Aprovided by MGI
Primary source: MGI:MGI:2442676
See related: Ensembl:ENSMUSG00000033502 AllianceGenome:MGI:2442676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cdc14; CDC14A2; CDC14a1; A830059A17Rik
Summary: Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Involved in sensory perception of sound. Located in kinociliary basal body and stereocilium tip. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 32. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to human CDC14A (cell division cycle 14A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 22.3), CNS E11.5 (RPKM 3.0) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G1; 3 50.24 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (116066202..116222390, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (116272553..116428741, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.
Title: Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.
Cdc14a has a role in spermatogenesis, sperm maturation and male fertility.
Title: Cdc14a has a role in spermatogenesis, sperm maturation and male fertility.
PLK1 promoted cell proliferation and insulin secretion while inhibiting cellular apoptosis in betaTC3 cell lines under both low and high glucose conditions. In addition, the phosphoregulation of Cdc14A by PLK1 may be involved in betaTC3 cell cycle regulation and insulin secretion under high glucose conditions.
Title: Phospho‑regulation of Cdc14A by polo‑like kinase 1 is involved in β‑cell function and cell cycle regulation.
CDC14A activity is necessary for hearing and male fertility.
Title: CDC14A phosphatase is essential for hearing and male fertility in mouse and human.
Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low.
Title: Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
CDC14A regulates oocyte maturation and functions to promote the meiosis I-to-meiosis II transition as its homolog does in budding yeast.
Title: The CDC14A phosphatase regulates oocyte maturation in mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (6) 1 citation

General gene information

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Markers

UniSTS:234810 (e-PCR)
- UniSTS:234810

Cdc14a (e-PCR), detects polymorphism
- UniSTS:506788

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exit from mitosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in kinociliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in kinocilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in stereocilium tip	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dual specificity protein phosphatase CDC14A

Names: CDC14 cell division cycle 14 homolog A

NP_001074287.1

EC 3.1.3.16

EC 3.1.3.48

NP_001167024.1

EC 3.1.3.16

EC 3.1.3.48

NP_001342575.1

EC 3.1.3.16

EC 3.1.3.48

NP_001365922.1

EC 3.1.3.16

EC 3.1.3.48

NP_001365923.1

EC 3.1.3.16

EC 3.1.3.48

XP_017175051.1

EC 3.1.3.16

EC 3.1.3.48

XP_030108457.1

EC 3.1.3.16

EC 3.1.3.48

XP_036018972.1

EC 3.1.3.16

EC 3.1.3.48

XP_036018973.1

EC 3.1.3.16

EC 3.1.3.48

XP_036018974.1

EC 3.1.3.16

EC 3.1.3.48

XP_036018975.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080818.2 → NP_001074287.1 dual specificity protein phosphatase CDC14A isoform 1

See identical proteins and their annotated locations for NP_001074287.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

AK052560, AK142294, BC072644

Consensus CDS

CCDS38611.1

UniProtKB/Swiss-Prot

Q6GQT0, Q8BZ66

Related

ENSMUSP00000087950.5, ENSMUST00000090464.7

Conserved Domains (3) summary

COG2453
Location:175 → 329

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:17 → 152

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:187 → 326

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001173553.2 → NP_001167024.1 dual specificity protein phosphatase CDC14A isoform 2

See identical proteins and their annotated locations for NP_001167024.1

Status: VALIDATED

Source sequence(s)

AK142294, BC072644

Consensus CDS

CCDS51058.1

UniProtKB/Swiss-Prot

Q6GQT0

Related

ENSMUSP00000102100.3, ENSMUST00000106491.7

Conserved Domains (3) summary

COG2453
Location:126 → 280

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:17 → 108

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:138 → 277

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001355646.1 → NP_001342575.1 dual specificity protein phosphatase CDC14A isoform 3

Status: VALIDATED

Source sequence(s)

AC165364, BC072644

Conserved Domains (1) summary

cl28904
Location:1 → 43

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_001378993.1 → NP_001365922.1 dual specificity protein phosphatase CDC14A isoform 4

Status: VALIDATED

Source sequence(s)

AC165364

Conserved Domains (2) summary

cd14499
Location:163 → 336

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:10 → 154

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
NM_001378994.1 → NP_001365923.1 dual specificity protein phosphatase CDC14A isoform 5

Status: VALIDATED

Source sequence(s)

AC165364

UniProtKB/TrEMBL

A0A5F8MPZ4

Related

ENSMUSP00000159189.2, ENSMUST00000239145.2

Conserved Domains (2) summary

cd14499
Location:105 → 278

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:1 → 96

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

116066202..116222390 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163080.1 → XP_036018973.1 dual specificity protein phosphatase CDC14A isoform X2

Conserved Domains (2) summary

cd14499
Location:178 → 351

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:10 → 169

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_036163082.1 → XP_036018975.1 dual specificity protein phosphatase CDC14A isoform X4

Conserved Domains (1) summary

cl28904
Location:1 → 43

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163079.1 → XP_036018972.1 dual specificity protein phosphatase CDC14A isoform X1

Conserved Domains (2) summary

cd14499
Location:178 → 351

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:10 → 169

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_036163081.1 → XP_036018974.1 dual specificity protein phosphatase CDC14A isoform X3

Conserved Domains (1) summary

cl28904
Location:1 → 43

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_030252597.2 → XP_030108457.1 dual specificity protein phosphatase CDC14A isoform X3

Conserved Domains (1) summary

cl28904
Location:1 → 43

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_017319562.3 → XP_017175051.1 dual specificity protein phosphatase CDC14A isoform X3

Conserved Domains (1) summary

cl28904
Location:1 → 43

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily