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    Far2 fatty acyl CoA reductase 2 [ Mus musculus (house mouse) ]

    Gene ID: 330450, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Far2provided by MGI
    Official Full Name
    fatty acyl CoA reductase 2provided by MGI
    Primary source
    MGI:MGI:2687035
    See related
    Ensembl:ENSMUSG00000030303 AllianceGenome:MGI:2687035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mlstd1; A230046P18
    Summary
    Enables alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to act upstream of or within wax biosynthetic process. Located in peroxisome. Is expressed in alveolar sulcus; anterior naris; brain; ovary; and skin. Used to study alopecia and dry eye syndrome. Orthologous to human FAR2 (fatty acyl-CoA reductase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in large intestine adult (RPKM 8.2), CNS E18 (RPKM 5.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Far2 in Genome Data Viewer
    Location:
    6 G3; 6 78.49 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (147948914..148084256)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148047416..148182758)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700049E15 gene Neighboring gene predicted gene 15762 Neighboring gene STARR-seq mESC enhancer starr_17826 Neighboring gene STARR-seq mESC enhancer starr_17827 Neighboring gene fatty acyl CoA reductase 2, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_17828 Neighboring gene STARR-seq mESC enhancer starr_17829 Neighboring gene STARR-seq mESC enhancer starr_17830 Neighboring gene RIKEN cDNA 4732416N19 gene Neighboring gene STARR-positive B cell enhancer ABC_E540 Neighboring gene STARR-positive B cell enhancer ABC_E3694 Neighboring gene ERGIC and golgi 2 Neighboring gene predicted gene, 52483 Neighboring gene transmembrane and tetratricopeptide repeat containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Formation of fatty alcohols-components of meibum lipids-by the fatty acyl-CoA reductase FAR2 is essential for dry eye prevention. Otsuka K, et al. FASEB J, 2022 Apr. PMID 35238077
    2. Detection and Classification of Novel Renal Histologic Phenotypes Using Deep Neural Networks. Sheehan S, et al. Am J Pathol, 2019 Sep. PMID 31220455, Free PMC Article
    3. Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia. Sundberg JP, et al. PLoS One, 2018. PMID 30372477, Free PMC Article
    4. Automatic glomerular identification and quantification of histological phenotypes using image analysis and machine learning. Sheehan SM, et al. Am J Physiol Renal Physiol, 2018 Dec 1. PMID 30256126, Free PMC Article
    5. Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene. Noordmans GA, et al. J Am Soc Nephrol, 2013 Dec. PMID 24009241, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Formation of fatty alcohols-components of meibum lipids-by the fatty acyl-CoA reductase FAR2 is essential for dry eye prevention.
      Title: Formation of fatty alcohols-components of meibum lipids-by the fatty acyl-CoA reductase FAR2 is essential for dry eye prevention.
    2. Results indicate fatty acyl CoA reductase 2 FAR2's role in the development of mesangial matrix expansion and chronic kidney disease.
      Title: FAR2 is associated with kidney disease in mice and humans.
    3. Far2 null mice provide further support for a central role for chronic sebadenitis in the development of a number of cicatricial alopecias. The Meibomian and clitoral glands (modified sebaceous glands) showed ducts dilated to various degrees that were associated with mild changes in the sebocytes as seen in the truncal skin.
      Title: Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia.
    4. Mouse strains with mesangial matrix expansion contain a 9-bp sequence in the 5' untranslated region of Far2 that is absent in most of the strains without it.
      Title: Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene.
    5. wax monoester synthesis in mammals involves a two step biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax synthase enzymes
      Title: Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family.
    6. fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids
      Title: Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC67167

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alcohol-forming long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within wax biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fatty acyl-CoA reductase 2
    Names
    male sterility domain-containing protein 1
    NP_001334445.1
    NP_848912.1
    XP_006507133.1
    XP_036022150.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347516.1 → NP_001334445.1  fatty acyl-CoA reductase 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK137298, AW048109, BC055759
      Consensus CDS
      CCDS85188.1
      UniProtKB/Swiss-Prot
      B2KFC6, Q3TTT7, Q7TNT2, Q8BH72, Q8CAK7
      Related
      ENSMUSP00000032443.8, ENSMUST00000032443.14
      Conserved Domains (2) summary
      cd05236
      Location:11 → 315
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein

    2. NM_178797.4 → NP_848912.1  fatty acyl-CoA reductase 2 isoform 2

      See identical proteins and their annotated locations for NP_848912.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences cause a translation frameshift and result in an isoform (2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK043388, AK043589
      Consensus CDS
      CCDS39718.1
      UniProtKB/Swiss-Prot
      Q7TNT2
      Related
      ENSMUSP00000107234.4, ENSMUST00000111607.4
      Conserved Domains (3) summary
      cd05236
      Location:11 → 315
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      PLN02996
      Location:7 → 447
      PLN02996; fatty acyl-CoA reductase
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      147948914..148084256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507070.5 → XP_006507133.1  fatty acyl-CoA reductase 2 isoform X1

      See identical proteins and their annotated locations for XP_006507133.1

      UniProtKB/Swiss-Prot
      B2KFC6, Q3TTT7, Q7TNT2, Q8BH72, Q8CAK7
      Conserved Domains (2) summary
      cd05236
      Location:11 → 315
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein

    2. XM_036166257.1 → XP_036022150.1  fatty acyl-CoA reductase 2 isoform X1

      UniProtKB/Swiss-Prot
      B2KFC6, Q3TTT7, Q7TNT2, Q8BH72, Q8CAK7
      Conserved Domains (2) summary
      cd05236
      Location:11 → 315
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357 → 447
      Sterile; Male sterility protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNT2.1 GenPept UniProtKB/Swiss-Prot:Q7TNT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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