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    Kcnn1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 84036, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnn1provided by MGI
    Official Full Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1provided by MGI
    Primary source
    MGI:MGI:1933993
    See related
    Ensembl:ENSMUSG00000002908 AllianceGenome:MGI:1933993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SK1; SKCa1; KCa2.1
    Summary
    Enables calmodulin binding activity. Predicted to be involved in potassium ion transmembrane transport. Located in cytoplasm and plasma membrane. Is expressed in brain; heart; peripheral nervous system; and testis. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 4.8), CNS E14 (RPKM 4.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnn1 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.27 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71295802..71318335, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70843158..70865691, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene interleukin 12 receptor, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E133 Neighboring gene arrestin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E3780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73389712-73389895 Neighboring gene STARR-positive B cell enhancer ABC_E8242 Neighboring gene coiled-coil domain containing 124 Neighboring gene STARR-seq mESC enhancer starr_21801 Neighboring gene solute carrier family 5 (sodium iodide symporter), member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional importance of Ca2+-activated K+ channels for lysophosphatidic acid-induced microglial migration. Schilling T, et al. Eur J Neurosci, 2004 Mar. PMID 15066143
    2. ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain. Wang H, et al. JCI Insight, 2024 May 21. PMID 38912580, Free PMC Article
    3. Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats. Oliveira MS, et al. Brain Res, 2010 Aug 12. PMID 20553876, Free PMC Article
    4. T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites. Cueni L, et al. Nat Neurosci, 2008 Jun. PMID 18488023
    5. Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1. Shmukler BE, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267657

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain.
      Title: ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain.
    2. Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 in kidney collecting duct cells.
      Title: Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel in kidney collecting duct cells.
    3. These data indicate an abnormal expression of SK channels and a possible dysfunction of these channels in pilocarpine-treated epileptic rats.
      Title: Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats.
    4. SK1, -2, -3, and IK1 (SK4) are expressed in islet cells and insulin-secreting cells and are able to influence glucose-induced calcium responses, thereby regulating insulin secretion.
      Title: Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses.
    5. At the cellular level, SK1-like immunoreactivity is primarily localized to somatic and dendritic structures in the mouse brain.
      Title: Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC115869

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small conductance calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables small conductance calcium-activated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small conductance calcium-activated potassium channel protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363407.2 → NP_001350336.1  small conductance calcium-activated potassium channel protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC019302, AC162446
      Consensus CDS
      CCDS52578.1
      UniProtKB/Swiss-Prot
      Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
      UniProtKB/TrEMBL
      A0A140T8Q8
      Related
      ENSMUSP00000148544.2, ENSMUST00000212611.2
      Conserved Domains (3) summary
      pfam02888
      Location:382 → 457
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:94 → 201
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:289 → 368
      Ion_trans_2; Ion channel

    2. NM_001363408.2 → NP_001350337.1  small conductance calcium-activated potassium channel protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC019302, AC162446
      Consensus CDS
      CCDS90413.1
      UniProtKB/Swiss-Prot
      Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
      UniProtKB/TrEMBL
      A0A1D5RMB2
      Related
      ENSMUSP00000148705.3, ENSMUST00000212509.3
      Conserved Domains (4) summary
      smart01053
      Location:382 → 457
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:94 → 201
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:289 → 368
      Ion_trans_2; Ion channel
      pfam13600
      Location:461 → 494
      DUF4140; N-terminal domain of unknown function (DUF4140)

    3. NM_032397.4 → NP_115773.2  small conductance calcium-activated potassium channel protein 1 isoform a

      See identical proteins and their annotated locations for NP_115773.2

      Status: VALIDATED

      Source sequence(s)
      AC019302, AC162446
      Consensus CDS
      CCDS52578.1
      UniProtKB/Swiss-Prot
      Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
      UniProtKB/TrEMBL
      A0A140T8Q8
      Related
      ENSMUSP00000105705.4, ENSMUST00000110078.5
      Conserved Domains (3) summary
      pfam02888
      Location:382 → 457
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:94 → 201
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:289 → 368
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71295802..71318335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243866.1 → XP_030099726.1  small conductance calcium-activated potassium channel protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
      UniProtKB/TrEMBL
      A0A140T8Q8
      Conserved Domains (3) summary
      pfam02888
      Location:382 → 457
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:94 → 201
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:289 → 368
      Ion_trans_2; Ion channel

    2. XM_030243865.1 → XP_030099725.1  small conductance calcium-activated potassium channel protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
      UniProtKB/TrEMBL
      A0A140T8Q8
      Conserved Domains (3) summary
      pfam02888
      Location:382 → 457
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:94 → 201
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:289 → 368
      Ion_trans_2; Ion channel

    3. XM_006509808.5 → XP_006509871.1  small conductance calcium-activated potassium channel protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006509871.1

      UniProtKB/Swiss-Prot
      Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
      UniProtKB/TrEMBL
      A0A140T8Q8
      Conserved Domains (3) summary
      pfam02888
      Location:382 → 457
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:94 → 201
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:289 → 368
      Ion_trans_2; Ion channel

    4. XM_036154395.1 → XP_036010288.1  small conductance calcium-activated potassium channel protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
      Conserved Domains (3) summary
      smart01053
      Location:352 → 420
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:94 → 201
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:289 → 351
      Ion_trans_2; Ion channel

    5. XM_006509806.3 → XP_006509869.2  small conductance calcium-activated potassium channel protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
      Conserved Domains (4) summary
      pfam02888
      Location:352 → 420
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:94 → 201
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:289 → 351
      Ion_trans_2; Ion channel
      pfam06160
      Location:396 → 460
      EzrA; Septation ring formation regulator, EzrA

    RNA

    1. XR_003947357.2 RNA Sequence

    2. XR_870467.3 RNA Sequence

    3. XR_379049.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQR3.2 GenPept UniProtKB/Swiss-Prot:Q9EQR3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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