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    LINC00460 long intergenic non-protein coding RNA 460 [ Homo sapiens (human) ]

    Gene ID: 728192, updated on 15-Oct-2024

    Summary

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    Official Symbol
    LINC00460provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 460provided by HGNC
    Primary source
    HGNC:HGNC:42809
    See related
    Ensembl:ENSG00000233532 AllianceGenome:HGNC:42809
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LINC00460 in Genome Data Viewer
    Location:
    13q33.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (106376564..106378595)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (105596926..105598957)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (107028912..107030943)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 38 Neighboring gene uncharacterized LOC107984626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:107001137-107001784 Neighboring gene Sharpr-MPRA regulatory region 6229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7981 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:107028450-107029649 Neighboring gene uncharacterized LOC124903246 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:107075540-107076185 Neighboring gene ribosomal protein L35 pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel long noncoding RNA linc00460 up-regulated by CBP/P300 promotes carcinogenesis in esophageal squamous cell carcinoma. Liang Y, et al. Biosci Rep, 2017 Oct 31. PMID 28939763, Free PMC Article
    2. Long noncoding RNA LINC00460 targets miR-539/MMP-9 to promote meningioma progression and metastasis. Xing H, et al. Biomed Pharmacother, 2018 Sep. PMID 29906745
    3. Pancreatic ductal adenocarcinoma cells regulated the gemcitabine-resistance function of CAFs by LINC00460. Zhu XX, et al. Cancer Sci, 2022 Nov. PMID 36047966, Free PMC Article
    4. Downregulation of long noncoding RNA LINC00460 expression suppresses tumor growth in vitro and in vivo in gastric cancer. Zhang S, et al. Cancer Biomark, 2019. PMID 30909185
    5. LINC00460 facilitated tongue squamous cell carcinoma progression via the miR-320b/IGF2BP3 axis. Wu K, et al. Oral Dis, 2022 Sep. PMID 33660359

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo.
      Title: LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo.
    2. Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10.
      Title: Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10.
    3. LINC00460 Promotes Cutaneous Squamous Cell Carcinoma Progression Through Stabilizing ELAVL1 Protein.
      Title: LINC00460 Promotes Cutaneous Squamous Cell Carcinoma Progression Through Stabilizing ELAVL1 Protein.
    4. Long non-coding RNA LINC00460 contributes as a potential prognostic biomarker through its oncogenic role with ANXA2 in colorectal polyps.
      Title: Long non‑coding RNA LINC00460 contributes as a potential prognostic biomarker through its oncogenic role with ANXA2 in colorectal polyps.
    5. LINC00460 Facilitates Cell Proliferation and Inhibits Ferroptosis in Breast Cancer Through the miR-320a/MAL2 Axis.
      Title: LINC00460 Facilitates Cell Proliferation and Inhibits Ferroptosis in Breast Cancer Through the miR-320a/MAL2 Axis.
    6. Pancreatic ductal adenocarcinoma cells regulated the gemcitabine-resistance function of CAFs by LINC00460.
      Title: Pancreatic ductal adenocarcinoma cells regulated the gemcitabine-resistance function of CAFs by LINC00460.
    7. LINC00460 facilitated tongue squamous cell carcinoma progression via the miR-320b/IGF2BP3 axis.
      Title: LINC00460 facilitated tongue squamous cell carcinoma progression via the miR-320b/IGF2BP3 axis.
    8. LINC00460 promotes pancreatic cancer progression by sponging miR-491-5p.
      Title: LINC00460 promotes pancreatic cancer progression by sponging miR-491-5p.
    9. lncRNA LINC00460 Functions as a Competing Endogenous RNA and Regulates Expression of BGN by Sponging miR-149-5p in Colorectal Cancer.
      Title: lncRNA LINC00460 Functions as a Competing Endogenous RNA and Regulates Expression of BGN by Sponging miR-149-5p in Colorectal Cancer.
    10. Downregulation of long non-coding RNA LINC00460 inhibits the proliferation, migration and invasion, and promotes apoptosis of pancreatic cancer cells via modulation of the miR-320b/ARF1 axis.
      Title: Downregulation of long non-coding RNA LINC00460 inhibits the proliferation, migration and invasion, and promotes apoptosis of pancreatic cancer cells via modulation of the miR-320b/ARF1 axis.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_034119.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL136159

    2. NR_163477.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL136159
      Related
      ENST00000435024.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      106376564..106378595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      105596926..105598957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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