BAT2 branched-chain-amino-acid transaminase BAT2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BAT2
Official Full Name: branched-chain-amino-acid transaminase BAT2
Primary source: SGD:S000003909
Locus tag: YJR148W
See related: AllianceGenome:SGD:S000003909; FungiDB:YJR148W; VEuPathDB:YJR148W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ECA40; TWT2
Summary: Enables branched-chain-amino-acid transaminase activity. Involved in branched-chain amino acid biosynthetic process and branched-chain amino acid catabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in hypervalinemia and hyperleucine-isoleucinemia. Orthologous to several human genes including BCAT2 (branched chain amino acid transaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BAT2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (705744..706874)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Effects of Catabolism Relationships of Leucine and Isoleucine with BAT2 Gene of Saccharomyces cerevisiae on High Alcohols and Esters.
Title: The Effects of Catabolism Relationships of Leucine and Isoleucine with BAT2 Gene of Saccharomyces cerevisiae on High Alcohols and Esters.
BAT1 and BAT2 differential expression and subcellular relocalization has resulted in distribution of the biosynthetic and catabolic roles of ancestral BCAT in two isozymes improving BCAA metabolism and constituting an adaptation to facultative metabolism.
Title: Saccharomyces cerevisiae Bat1 and Bat2 aminotransferases have functionally diverged from the ancestral-like Kluyveromyces lactis orthologous enzyme.
adjustment of BAT gene expression could play an important role in assisting winemakers in their endeavour to produce wines with specific flavour profiles.
Title: The effect of increased branched-chain amino acid transaminase activity in yeast on the production of higher alcohols and on the flavour profiles of wine and distillates.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables L-isoleucine-2-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables L-valine-2-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables branched-chain-amino-acid transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables branched-chain-amino-acid transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables branched-chain-amino-acid transaminase activity	IEA Inferred from Electronic Annotation more info
enables methionine-oxo-acid transaminase activity	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-methionine salvage from methylthioadenosine	IEA Inferred from Electronic Annotation more info
involved_in L-valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-valine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in branched-chain amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branched-chain amino acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branched-chain amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoleucine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: branched-chain-amino-acid transaminase BAT2

NP_012682.1

EC 2.6.1.42

Cytosolic branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase; BAT2 has a paralog, BAT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

705744..706874

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181806.1 → NP_012682.1 TPA: branched-chain-amino-acid transaminase BAT2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012682.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWW6, P47176, Q07124

UniProtKB/TrEMBL

A6ZQA4, B3LQM7, B5VLT5, N1P0C2

Conserved Domains (1) summary

cd01557
Location:61 → 361

BCAT_beta_family; Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The ...