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    ZNF747 zinc finger protein 747 [ Homo sapiens (human) ]

    Gene ID: 65988, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF747provided by HGNC
    Official Full Name
    zinc finger protein 747provided by HGNC
    Primary source
    HGNC:HGNC:28350
    See related
    Ensembl:ENSG00000169955 AllianceGenome:HGNC:28350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 3.6), kidney (RPKM 3.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF747 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30530367..30534858, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30917336..30921826, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30541688..30546179, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha L Neighboring gene ITGAL antisense RNA 1 Neighboring gene microRNA 4518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10709 Neighboring gene zinc finger protein 768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30544613-30545124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7378 Neighboring gene Sharpr-MPRA regulatory region 7881 Neighboring gene ZNF747 divergent transcript Neighboring gene RPL7L1 pseudogene 16 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30552221-30552866 Neighboring gene uncharacterized LOC124903677 Neighboring gene Sharpr-MPRA regulatory region 8694

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
    2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Loftus BJ, et al. Genomics, 1999 Sep 15. PMID 10493829
    3. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Dart AE, et al. J Cell Biol, 2015 Nov 23. PMID 26598620, Free PMC Article
    4. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Adams MD, et al. Nature, 1995 Sep 28. PMID 7566098
    5. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 747 (ZNF747) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2474

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 747
    Names
    KRAB domain-containing protein ZNF747

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305018.2 → NP_001291947.1  zinc finger protein 747 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA316824, BC001361, BE327668, BM461939, CA429734, DC305764
      Consensus CDS
      CCDS92140.1
      UniProtKB/TrEMBL
      A0A8I5KWK6, B7ZAD9
      Related
      ENSP00000509633.1, ENST00000693075.1
      Conserved Domains (5) summary
      smart00349
      Location:37 → 96
      KRAB; krueppel associated box
      COG5048
      Location:236 → 273
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:212 → 232
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:37 → 76
      KRAB; KRAB box
      pfam13465
      Location:252 → 275
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001305019.2 → NP_001291948.1  zinc finger protein 747 isoform 2

      See identical proteins and their annotated locations for NP_001291948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AA316824, AK316254, BC001361, BE327668, BM461939, CA429734
      Consensus CDS
      CCDS76856.1
      UniProtKB/Swiss-Prot
      A8K827, B7WNU3, B7Z5R0, Q59FB4, Q96NW0, Q9BV97
      UniProtKB/TrEMBL
      B7ZAD9
      Related
      ENSP00000457274.1, ENST00000568028.1
      Conserved Domains (5) summary
      smart00349
      Location:37 → 96
      KRAB; krueppel associated box
      COG5048
      Location:235 → 272
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:211 → 231
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:37 → 76
      KRAB; KRAB box
      pfam13465
      Location:251 → 274
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001305020.2 → NP_001291949.1  zinc finger protein 747 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes an alternate segment in the 5' coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. These differences result in a frameshift compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA316824, AB209546, BC001361, BE327668, BM461939, BP359683, CA429734
      Consensus CDS
      CCDS76855.1
      UniProtKB/Swiss-Prot
      Q9BV97
      Related
      ENSP00000378528.3, ENST00000395094.3
      Conserved Domains (2) summary
      smart00349
      Location:37 → 77
      KRAB; krueppel associated box
      pfam01352
      Location:37 → 76
      KRAB; KRAB box

    4. NM_023931.4 → NP_076420.1  zinc finger protein 747 isoform 3

      See identical proteins and their annotated locations for NP_076420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate segment in the 5' coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA316824, BC001361, BE327668, BM461939, CA429734
      Consensus CDS
      CCDS10682.1
      Related
      ENSP00000252799.3, ENST00000252799.3
      Conserved Domains (1) summary
      pfam01352
      Location:37 → 77
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      30530367..30534858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      30917336..30921826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BV97.2 GenPept UniProtKB/Swiss-Prot:Q9BV97

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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