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    WT1-AS WT1 antisense RNA [ Homo sapiens (human) ]

    Gene ID: 51352, updated on 10-Dec-2024

    Summary

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    Official Symbol
    WT1-ASprovided by HGNC
    Official Full Name
    WT1 antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:18135
    See related
    Ensembl:ENSG00000183242 MIM:607899; AllianceGenome:HGNC:18135
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WIT1; WIT-1; WT1AS; WT1-AS1
    Summary
    This gene is located upstream of the Wilms tumor 1 (WT1) gene; these two genes are bi-directionally transcribed from the same promoter region. This gene is imprinted in kidney, with preferential expression from the paternal allele. Imprinting defects at chromosome 11p13 may contribute to tumorigenesis. [provided by RefSeq, May 2014]
    Expression
    Biased expression in ovary (RPKM 4.7), endometrium (RPKM 3.7) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See WT1-AS in Genome Data Viewer
    Location:
    11p13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (32435518..32458769)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (32571003..32594257)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32457064..32480315)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4563 Neighboring gene thioesterase superfamily member 7, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 88 Neighboring gene HCNE2 enhancer upstream of PAX6 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:32380174-32380395 Neighboring gene WT1 3' enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3221 Neighboring gene WT1 intron 3 regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32449464-32450078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:32450079-32450691 Neighboring gene WT1/WT1-AS bi-directional promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32459559-32460416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32460417-32461272 Neighboring gene Sharpr-MPRA regulatory region 1868 Neighboring gene WT1 transcription factor Neighboring gene MPRA-validated peak1243 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4564 Neighboring gene MPRA-validated peak1244 silencer Neighboring gene MPRA-validated peak1246 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:32605088-32605740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3223 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 9 Neighboring gene eukaryotic translation initiation factor 3 subunit M Neighboring gene coiled-coil domain containing 73 Neighboring gene 60S ribosomal protein L34-like Neighboring gene ribosomal protein L34 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene. Plass C, et al. Oncogene, 1999 May 20. PMID 10340388
    2. Decreased expression of long non-coding RNA WT1-AS promotes cell proliferation and invasion in gastric cancer. Du T, et al. Biochim Biophys Acta, 2016 Jan. PMID 26449525
    3. Cloning of novel Wilms tumor gene (WT1) cDNAs; evidence for antisense transcription of WT1. Eccles MR, et al. Oncogene, 1994 Jul. PMID 8208551
    4. WT1 and WT1-AS genes are inactivated by promoter methylation in ovarian clear cell adenocarcinoma. Kaneuchi M, et al. Cancer, 2005 Nov 1. PMID 16134181
    5. Variants in the Wilms' tumor gene are associated with focal segmental glomerulosclerosis in the African American population. Orloff MS, et al. Physiol Genomics, 2005 Apr 14. PMID 15687485

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Up-regulation of lncRNA WT1-AS ameliorates Abeta-stimulated neuronal injury through modulation of miR-186-5p/CCND2 axis in Alzheimer's disease.
      Title: Up-regulation of lncRNA WT1-AS ameliorates Aβ-stimulated neuronal injury through modulation of miR-186-5p/CCND2 axis in Alzheimer's disease.
    2. Overexpression of long non-coding RNA WT1-AS or silencing of PIK3AP1 are inhibitory to cervical cancer progression.
      Title: Overexpression of long non-coding RNA WT1-AS or silencing of PIK3AP1 are inhibitory to cervical cancer progression.
    3. WT1-AS/IGF2BP2 Axis Is a Potential Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma According to ceRNA Network Comprehensive Analysis Combined with Experiments.
      Title: WT1-AS/IGF2BP2 Axis Is a Potential Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma According to ceRNA Network Comprehensive Analysis Combined with Experiments.
    4. Unravelling the Role of LncRNA WT1-AS/miR-206/NAMPT Axis as Prognostic Biomarkers in Lung Adenocarcinoma.
      Title: Unravelling the Role of LncRNA WT1-AS/miR-206/NAMPT Axis as Prognostic Biomarkers in Lung Adenocarcinoma.
    5. LncRNA WT1-AS downregulates lncRNA UCA1 to suppress non-small cell lung cancer and predicts poor survival.
      Title: LncRNA WT1-AS downregulates lncRNA UCA1 to suppress non-small cell lung cancer and predicts poor survival.
    6. LncRNA WT1-AS over-expression inhibits non-small cell lung cancer cell stemness by down-regulating TGF-beta1.
      Title: LncRNA WT1-AS over-expression inhibits non-small cell lung cancer cell stemness by down-regulating TGF-β1.
    7. Long Noncoding RNA WT1-AS Inhibit Cell Malignancy via miR-494-3p in Glioma.
      Title: Long Noncoding RNA WT1-AS Inhibit Cell Malignancy via miR-494-3p in Glioma.
    8. Long non-coding RNA WT1-AS inhibits cell aggressiveness via miR-203a-5p/FOXN2 axis and is associated with prognosis in cervical cancer.
      Title: Long non-coding RNA WT1-AS inhibits cell aggressiveness via miR-203a-5p/FOXN2 axis and is associated with prognosis in cervical cancer.
    9. WT1-AS overexpression caused inhibited migration and invasion of TNBC cells. TGF-beta1 overexpression showed opposite functions and reduced the effects of WT1-AS overexpression. WT1-AS may downregulate TGF-beta to inhibit the migration and invasion of TNBC cells.
      Title: LncRNA WT1-AS Inhibits Triple-Negative Breast Cancer Cell Migration and Invasion by Downregulating Transforming Growth Factor β1.
    10. Tumor protein p53 (P53) was down-regulated in cervical squamous cell carcinoma (CSCC) tissues and positively correlated with LncRNA WT1-AS. WT1-AS.
      Title: LncRNA WT1-AS up-regulates p53 to inhibit the proliferation of cervical squamous carcinoma cells.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • WT1 antisense RNA (non-protein coding)
    • Wilms tumor associated protein
    • Wilms tumor upstream neighbor 1

    Clone Names

    • MGC120207, MGC120208, MGC120209

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_023920.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon, contains an alternate 5' exon, and differs in the 3' exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AL049692, DA743604, DB262871, DQ289488

    2. NR_120546.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      DQ289489, DQ289490

    3. NR_120547.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains two alternate 5' exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AL049692

    4. NR_120548.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) shares no exons with variant 1, but contains the same 5' exon as variant 2 and four alternate 3' exons. The transcript is shorter than variants 1 and 2.
      Source sequence(s)
      AL049692
      Related
      ENST00000525436.2

    5. NR_120549.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) shares no exons with variant 1, but contains the same 5' exon as variant 2 and an alternate 3' exon. The transcript is shorter than variants 1 and 2.
      Source sequence(s)
      AL049692
      Related
      ENST00000459866.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      32435518..32458769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      32571003..32594257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_015855.3: Suppressed sequence

      Description
      NM_015855.3: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06250.2 GenPept UniProtKB/Swiss-Prot:Q06250

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials