RAB25 RAB25, member RAS oncogene family [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB25provided by HGNC
Official Full Name: RAB25, member RAS oncogene familyprovided by HGNC
Primary source: HGNC:HGNC:18238
See related: Ensembl:ENSG00000132698 MIM:612942; AllianceGenome:HGNC:18238
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CATX-8; RAB11C
Summary: The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]
Expression: Biased expression in esophagus (RPKM 128.3), skin (RPKM 60.6) and 12 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (156061160..156070504)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (155199625..155208969)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (156030951..156040295)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors.
Title: Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors.
Expression of Rab25 is down-regulated in the foreskin of children with hypospadias.
Title: Expression of Rab25 is down-regulated in the foreskin of children with hypospadias.
Long non-coding RNA LINC00173 serves as sponge for miR-338-3p to promote prostate cancer progression via regulating Rab25.
Title: Long non-coding RNA LINC00173 serves as sponge for miR-338-3p to promote prostate cancer progression via regulating Rab25.
Loss of Rab25 promotes the development and neoplastic transition of skin squamous cell carcinoma through dysregulation of integrin trafficking.
Title: Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking.
Promoter DNA methylation analysis reveals a novel diagnostic CpG-based biomarker and RAB25 hypermethylation in clear cell renel cell carcinoma
Title: Promoter DNA methylation analysis reveals a novel diagnostic CpG-based biomarker and RAB25 hypermethylation in clear cell renel cell carcinoma.
Rab25 overexpression induced erlotinib resistance, whereas Rab25 knockdown reversed this refractoriness in vitro and in vivo. Moreover, Rab25 interacts with beta1 integrin and promotes its trafficking to the cytoplasmic membrane.
Title: Rab25 promotes erlotinib resistance by activating the β1 integrin/AKT/β-catenin pathway in NSCLC.
Rab25 modulates cancer cell invasion through coordinated regulation of beta1-integrin to activation of EGFR and expression of VEGF-A to increase the level of Snail protein and subsequent Fascin expression.
Title: Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.
ZEB2 directly binds to E-box sequences in the RAB25 promoter.ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 during epithelial-to-mesenchymal transition.
Title: ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition.
Results indicated that miR-577 suppressed EMT by inhibiting Rab25 expression in breast cancer (BC). MiR-577 and Rab25 are considered potential targets of BC treatment.
Title: MiR-577 suppresses epithelial-mesenchymal transition and metastasis of breast cancer by targeting Rab25.
Rab25 is amplified and enhances aggressiveness in luminal B cancers while in claudin-low tumors, Rab25 is lost indicating possible anti-tumor functions
Title: Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-11851 (e-PCR)
- UniSTS:60032

A005X41 (e-PCR)
- UniSTS:77511

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables myosin V binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in pseudopodium organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in pseudopodium	IDA Inferred from Direct Assay more info	PubMed
located_in pseudopodium membrane	IEA Inferred from Electronic Annotation more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020387.4 → NP_065120.2 ras-related protein Rab-25 precursor

See identical proteins and their annotated locations for NP_065120.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer, protein-coding transcript.

Source sequence(s)

BC009831, BP263750

Consensus CDS

CCDS41413.1

UniProtKB/Swiss-Prot

P57735, Q5VYA2, Q8NG24, Q96GB1, Q9BT12

Related

ENSP00000354376.5, ENST00000361084.10

Conserved Domains (1) summary

cd01868
Location:11 → 174

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

RNA

NR_133653.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC009831, BP263750, BP273992