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    GPX8 glutathione peroxidase 8 (putative) [ Homo sapiens (human) ]

    Gene ID: 493869, updated on 27-Nov-2024

    Summary

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    Official Symbol
    GPX8provided by HGNC
    Official Full Name
    glutathione peroxidase 8 (putative)provided by HGNC
    Primary source
    HGNC:HGNC:33100
    See related
    Ensembl:ENSG00000164294 MIM:617172; AllianceGenome:HGNC:33100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPx-8; UNQ847; EPLA847; GSHPx-8
    Summary
    Enables peroxidase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta (RPKM 14.8), endometrium (RPKM 12.4) and 20 other tissues See more
    Orthologs
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    Genomic context

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    See GPX8 in Genome Data Viewer
    Location:
    5q11.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (55160171..55167297)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (55987458..55994584)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54455999..54463125)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene granzyme A pseudogene 1 Neighboring gene granzyme A Neighboring gene cell division cycle 20B Neighboring gene microRNA 449a Neighboring gene microRNA 449b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPX8(+) cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment. Bai Y, et al. BMC Med Genomics, 2024 Mar 21. PMID 38515109, Free PMC Article
    2. Regulation of Calcium Fluxes by GPX8, a Type-II Transmembrane Peroxidase Enriched at the Mitochondria-Associated Endoplasmic Reticulum Membrane. Yoboue ED, et al. Antioxid Redox Signal, 2017 Sep 20. PMID 28129698
    3. GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses. Chen Z, et al. Front Immunol, 2023. PMID 37795080, Free PMC Article
    4. GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum. Ramming T, et al. Free Radic Biol Med, 2014 May. PMID 24566470
    5. GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells. Chen X, et al. Epigenetics, 2023 Dec. PMID 37170591, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration.
      Title: Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration.
    2. GPX8[+] cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment.
      Title: GPX8(+) cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment.
    3. GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses.
      Title: GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses.
    4. GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells.
      Title: GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells.
    5. GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma.
      Title: GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma.
    6. GPx8 regulates apoptosis and autophagy in esophageal squamous cell carcinoma through the IRE1/JNK pathway.
      Title: GPx8 regulates apoptosis and autophagy in esophageal squamous cell carcinoma through the IRE1/JNK pathway.
    7. GPX8 promotes migration and invasion by regulating epithelial characteristics in non-small cell lung cancer.
      Title: GPX8 promotes migration and invasion by regulating epithelial characteristics in non-small cell lung cancer.
    8. Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding.
      Title: Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding.
    9. Glutathione Peroxidase 8 as a Prognostic Biomarker of Gastric Cancer: An Analysis of The Cancer Genome Atlas (TCGA) Data.
      Title: Glutathione Peroxidase 8 as a Prognostic Biomarker of Gastric Cancer: An Analysis of The Cancer Genome Atlas (TCGA) Data.
    10. The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.
      Title: The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable glutathione peroxidase 8
    NP_001008398.2
    NP_001293126.1
    NP_001293127.1
    NP_001293130.1
    XP_006714694.1
    XP_054208642.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008397.4 → NP_001008398.2  probable glutathione peroxidase 8 isoform a

      See identical proteins and their annotated locations for NP_001008398.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK074216, BM988796, BX537894, BX647770, CN390753
      Consensus CDS
      CCDS34156.1
      UniProtKB/Swiss-Prot
      Q8TED1
      Related
      ENSP00000423822.1, ENST00000503787.6
      Conserved Domains (1) summary
      TIGR02540
      Location:46 → 198
      gpx7; putative glutathione peroxidase Gpx7

    2. NM_001306197.2 → NP_001293126.1  probable glutathione peroxidase 8 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' terminal exon, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK298545, BM988796, BX537894, BX647770, CN390753
      Consensus CDS
      CCDS78009.1
      UniProtKB/TrEMBL
      E7ETY7
      Related
      ENSP00000427466.1, ENST00000515370.1
      Conserved Domains (1) summary
      cl00388
      Location:15 → 147
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. NM_001306198.2 → NP_001293127.1  probable glutathione peroxidase 8 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK074216, AK307365, BM988796, BX537894, BX647770, CN390753
      Consensus CDS
      CCDS82997.1
      UniProtKB/TrEMBL
      J3KNB5
      Related
      ENSP00000296734.6, ENST00000296734.6
      Conserved Domains (1) summary
      cl00388
      Location:46 → 69
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    4. NM_001306201.2 → NP_001293130.1  probable glutathione peroxidase 8 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in both the 5' terminal exon and in an internal exon, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
      Source sequence(s)
      AK074216, BM988796, BX537894, BX647770, CN390753, DA660205
      UniProtKB/Swiss-Prot
      Q8TED1
      Conserved Domains (1) summary
      cl00388
      Location:14 → 105
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RNA

    1. NR_131336.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) splices out an alternate segment in the 5' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BM988796, BX537894, BX647770, CN390753
      Related
      ENST00000506123.5

    2. NR_131337.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) splices out an alternate segment in the 5' terminal exon, and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BM835879, BM988796, BX537894, BX647770, CN390753

    3. NR_131338.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) splices out an alternate segment in the 5' terminal exon, and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK074216, BM988796, BX537894, BX647770, CN390753, HY174481

    4. NR_131340.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK074216, BG620710, BM988796, BX537894, BX647770, CN390753

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      55160171..55167297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714631.3 → XP_006714694.1  probable glutathione peroxidase 8 isoform X1

      Conserved Domains (1) summary
      TIGR02540
      Location:46 → 199
      gpx7; putative glutathione peroxidase Gpx7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      55987458..55994584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352667.1 → XP_054208642.1  probable glutathione peroxidase 8 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TED1.2 GenPept UniProtKB/Swiss-Prot:Q8TED1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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