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    ZNF844 zinc finger protein 844 [ Homo sapiens (human) ]

    Gene ID: 284391, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF844provided by HGNC
    Official Full Name
    zinc finger protein 844provided by HGNC
    Primary source
    HGNC:HGNC:25932
    See related
    Ensembl:ENSG00000223547 AllianceGenome:HGNC:25932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 5.6), ovary (RPKM 4.7) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF844 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12064731..12081565)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12192948..12209800)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12175546..12192380)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF433 and ZNF878 antisense RNA 1 Neighboring gene zinc finger protein 433 Neighboring gene RNA, 5S ribosomal pseudogene 465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10140 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12163610-12164115 Neighboring gene zinc finger protein 878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10141 Neighboring gene RNA, 5S ribosomal pseudogene 466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10143 Neighboring gene zinc finger family member 788, pseudogene Neighboring gene ribosomal L24 domain containing 1 pseudogene 8 Neighboring gene RNA, 5S ribosomal pseudogene 467

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle. Song N, et al. Mol Carcinog, 2023 Oct. PMID 37314216
    2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14959, MGC150553

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 844

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136501.3 → NP_001129973.1  zinc finger protein 844

      See identical proteins and their annotated locations for NP_001129973.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
      Source sequence(s)
      AC022415, AK098117, AL832297
      Consensus CDS
      CCDS45985.1
      UniProtKB/Swiss-Prot
      Q08AG5, Q5JPI8
      UniProtKB/TrEMBL
      A0A494C069
      Related
      ENSP00000392024.3, ENST00000439326.8
      Conserved Domains (5) summary
      smart00349
      Location:4 → 46
      KRAB; krueppel associated box
      COG5048
      Location:223 → 305
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:239 → 262
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_134326.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC022415, AK299732, AL832297, BC125185

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12064731..12081565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12192948..12209800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08AG5.1 GenPept UniProtKB/Swiss-Prot:Q08AG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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