PLCD3 phospholipase C delta 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLCD3provided by HGNC
Official Full Name: phospholipase C delta 3provided by HGNC
Primary source: HGNC:HGNC:9061
See related: Ensembl:ENSG00000161714 MIM:608795; AllianceGenome:HGNC:9061
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PLC-delta-3
Summary: This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]
Expression: Broad expression in colon (RPKM 22.8), urinary bladder (RPKM 21.5) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.31

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (45108959..45132515, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (45962835..45986399, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (43186327..43209882, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling.
Title: PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling.
Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression.
Title: Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression.
CircMAP3K4 protects human lens epithelial cells from H2O2-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract.
Title: CircMAP3K4 protects human lens epithelial cells from H(2)O(2)-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract.
Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway.
Title: Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway.
Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms.
Title: Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms.
Results identified an interaction between PLCD3 and FLOT2. Inhibition of PLCD3 expression impaired the malignant potential of nasopharyngeal carcinoma (NPC) cells, by restraining its growth, proliferation, mobility and migration. This study demonstrated that PLCD3 may be an oncogenic protein in NPC and that it plays an important role in the progression of NPC partially by interacting with Flot2.
Title: PLCD3, a flotillin2-interacting protein, is involved in proliferation, migration and invasion of nasopharyngeal carcinoma cells.
PLCdelta3 regulates microvilli formation in enterocytes and the radial migration of neurons in the cerebral cortex of the developing brain. [review]
Title: Physiological functions of phospholipase Cδ1 and phospholipase Cδ3.
In mouse, Plcd1 and Plcd3 may act together in murine hair follicles.
Title: Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

D10S275 (e-PCR)
- UniSTS:147992

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

D10S16 (e-PCR)
- UniSTS:155756

D1S1423 (e-PCR)
- UniSTS:149619

D1S1425 (e-PCR)
- UniSTS:149621

D11S3114 (e-PCR)
- UniSTS:152207

D16S325 (e-PCR)
- UniSTS:147089

PLCD3_8123 (e-PCR)
- UniSTS:471718

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in labyrinthine layer blood vessel development	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Names: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3; PLC delta3; phosphoinositide phospholipase C-delta-3

NP_588614.1

EC 3.1.4.11

XP_011522555.1

EC 3.1.4.11

XP_024306322.1

EC 3.1.4.11

XP_054170882.1

EC 3.1.4.11

XP_054170883.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133373.5 → NP_588614.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

See identical proteins and their annotated locations for NP_588614.1

Status: REVIEWED

Source sequence(s)

AC002117, AL834392, BC072384, BU621728, HY169731

Consensus CDS

CCDS74077.1

UniProtKB/Swiss-Prot

Q8N3E9, Q8TEC1, Q8TF37, Q96FL6

Related

ENSP00000479636.1, ENST00000619929.5

Conserved Domains (7) summary

cd00275
Location:660 → 787

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08630
Location:336 → 631

PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3

PLN02228
Location:255 → 772

PLN02228; Phosphoinositide phospholipase C

cd13363
Location:65 → 181

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

pfam00169
Location:70 → 170

PH; PH domain

pfam09279
Location:255 → 336

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam14788
Location:201 → 250

EF-hand_10; EF hand

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

45108959..45132515 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024450554.2 → XP_024306322.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1

Conserved Domains (4) summary

cd00275
Location:705 → 832

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08630
Location:336 → 676

PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3

cd13363
Location:65 → 181

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

cd16218
Location:186 → 324

EFh_PI-PLCdelta3; EF-hand motif found in phosphoinositide phospholipase C delta 3 (PI-PLC-delta3)
XM_011524253.4 → XP_011522555.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

Conserved Domains (5) summary

cd13363
Location:65 → 181

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

pfam00169
Location:70 → 170

PH; PH domain

pfam09279
Location:255 → 336

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam14788
Location:201 → 250

EF-hand_10; EF hand

cl14615
Location:336 → 471

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

45962835..45986399 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054314907.1 → XP_054170882.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1
XM_054314908.1 → XP_054170883.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2