LYPD8 LY6/PLAUR domain containing 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LYPD8provided by HGNC
Official Full Name: LY6/PLAUR domain containing 8provided by HGNC
Primary source: HGNC:HGNC:44208
See related: Ensembl:ENSG00000259823 MIM:617067; AllianceGenome:HGNC:44208
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward colon (RPKM 65.3) See more
Orthologs: mouse all
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Genomic context

Location:: 1q44

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (248739415..248755759, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (248177673..248193983, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (248902716..248903170, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel disease.
Title: Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel disease.
Study results revealed that the expression of LYPD8 was significantly reduced in the colorectal cancer (CRC) tissue compared with that in precancerous tissue and normal tissue. The results also revealed increased levels of P65 and STAT3 phosphorylation and increased secretion of IL6 and TNFalpha in CRC tissue compared with levels in precancerous tissue.
Title: LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of IL‑6 and TNF‑α.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ly6/PLAUR domain-containing protein 8

Names: phospholipase inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085474.2 → NP_001078943.2 ly6/PLAUR domain-containing protein 8 preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AEKP01210869, CR589904, FP476111, FP885904

Consensus CDS

CCDS73059.1

UniProtKB/Swiss-Prot

A0A075B722, K7ELG6, Q6UX82

Related

ENSP00000466070.2, ENST00000590317.4
NM_001291283.2 → NP_001278212.2 ly6/PLAUR domain-containing protein 8 preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

CR589904, FP476111, FP885904

Consensus CDS

CCDS73059.1

UniProtKB/Swiss-Prot

A0A075B722, K7ELG6, Q6UX82