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    GLI4 GLI family zinc finger 4 [ Homo sapiens (human) ]

    Gene ID: 2738, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GLI4provided by HGNC
    Official Full Name
    GLI family zinc finger 4provided by HGNC
    Primary source
    HGNC:HGNC:4320
    See related
    Ensembl:ENSG00000250571 MIM:165280; AllianceGenome:HGNC:4320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HKR4; ZNF928
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 5.3), spleen (RPKM 4.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GLI4 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143267445..143276931)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144414875..144424319)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144349615..144359101)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144332854-144333354 Neighboring gene ZFP41 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144350631-144351453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144353055-144353555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144357207-144357850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144357851-144358494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144361711-144362353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28068 Neighboring gene MYC-induced long non-coding RNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144373076-144373651 Neighboring gene zinc finger protein 696

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Assignment of the gene encoding human Krüppel-related zinc finger protein 4 (GLI4) to 8q24.3 by fluorescent in situ hybridization. Kas K, et al. Cytogenet Cell Genet, 1996. PMID 8641133
    2. The GLI-Kruppel family of human genes. Ruppert JM, et al. Mol Cell Biol, 1988 Aug. PMID 2850480, Free PMC Article
    3. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
    4. Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. Davis ZH, et al. Mol Cell, 2015 Jan 22. PMID 25544563, Free PMC Article
    5. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein GLI4
    Names
    GLI-Kruppel family member GLI4 (oncogene HKR4)
    glioma-associated oncogene family zinc finger 4
    krueppel-related zinc finger protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138465.4 → NP_612474.1  zinc finger protein GLI4

      See identical proteins and their annotated locations for NP_612474.1

      Status: VALIDATED

      Source sequence(s)
      AI829114, BC014165, BI761835
      Consensus CDS
      CCDS6398.1
      UniProtKB/Swiss-Prot
      P10075, Q96CK9
      Related
      ENSP00000345024.1, ENST00000340042.2
      Conserved Domains (4) summary
      COG5048
      Location:181 → 343
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241 → 261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:183 → 205
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:281 → 304
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      143267445..143276931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      144414875..144424319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10075.2 GenPept UniProtKB/Swiss-Prot:P10075

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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