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    Zfp322a zinc finger protein 322A [ Mus musculus (house mouse) ]

    Gene ID: 218100, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp322aprovided by MGI
    Official Full Name
    zinc finger protein 322Aprovided by MGI
    Primary source
    MGI:MGI:2442566
    See related
    Ensembl:ENSMUSG00000046351 AllianceGenome:MGI:2442566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf322; Znf322a
    Summary
    Enables DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of stem cell population maintenance and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and trunk somite. Orthologous to human ZNF322 (zinc finger protein 322). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.1), CNS E14 (RPKM 5.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp322a in Genome Data Viewer
    Location:
    13 A3.1; 13 9.55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23537273..23553378, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23353103..23369208, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930557F10 gene Neighboring gene RIKEN cDNA 4930586N03 gene Neighboring gene nuclear encoded tRNA isoleucine 9 (anticodon AAT) Neighboring gene nuclear encoded tRNA methionine 12 (anticodon CAT) Neighboring gene STARR-seq mESC enhancer starr_33930 Neighboring gene STARR-seq mESC enhancer starr_33932 Neighboring gene STARR-positive B cell enhancer mm9_chr13:23460983-23461284 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene nuclear encoded tRNA isoleucine 3 (anticodon AAT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency. Ma H, et al. PLoS Genet, 2014 Feb. PMID 24550733, Free PMC Article
    2. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • RP23-9O13.9, 9630054P07Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of stem cell population maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 322

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111107.2 → NP_001104577.1  zinc finger protein 322

      See identical proteins and their annotated locations for NP_001104577.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK036302, AL669819, CF743666
      Consensus CDS
      CCDS26337.1
      UniProtKB/Swiss-Prot
      Q8BZ89, Q8K0A0, Q91W42
      UniProtKB/TrEMBL
      Q3TDD5
      Conserved Domains (3) summary
      COG5048
      Location:79 → 229
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:179 → 203
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001286155.1 → NP_001273084.1  zinc finger protein 322

      See identical proteins and their annotated locations for NP_001273084.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK036302, AL669819, CF743666
      Consensus CDS
      CCDS26337.1
      UniProtKB/Swiss-Prot
      Q8BZ89, Q8K0A0, Q91W42
      UniProtKB/TrEMBL
      Q3TDD5
      Conserved Domains (3) summary
      COG5048
      Location:79 → 229
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:179 → 203
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001286156.1 → NP_001273085.1  zinc finger protein 322

      See identical proteins and their annotated locations for NP_001273085.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK036302, AL669819, CF743666
      Consensus CDS
      CCDS26337.1
      UniProtKB/Swiss-Prot
      Q8BZ89, Q8K0A0, Q91W42
      UniProtKB/TrEMBL
      Q3TDD5
      Conserved Domains (3) summary
      COG5048
      Location:79 → 229
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:179 → 203
      zf-H2C2_2; Zinc-finger double domain

    4. NM_172586.4 → NP_766174.1  zinc finger protein 322

      See identical proteins and their annotated locations for NP_766174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK036302, AL669819
      Consensus CDS
      CCDS26337.1
      UniProtKB/Swiss-Prot
      Q8BZ89, Q8K0A0, Q91W42
      UniProtKB/TrEMBL
      Q3TDD5
      Related
      ENSMUSP00000061524.3, ENSMUST00000050101.9
      Conserved Domains (3) summary
      COG5048
      Location:79 → 229
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:179 → 203
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      23537273..23553378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZ89.1 GenPept UniProtKB/Swiss-Prot:Q8BZ89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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