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    Emc2 ER membrane protein complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 66736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Emc2provided by MGI
    Official Full Name
    ER membrane protein complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1913986
    See related
    Ensembl:ENSMUSG00000022337 AllianceGenome:MGI:1913986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ttc35; 4921531G14Rik
    Summary
    Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in mitochondrion. Orthologous to human EMC2 (ER membrane protein complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 27.1), cerebellum adult (RPKM 21.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Emc2 in Genome Data Viewer
    Location:
    15 B3.2; 15 16.75 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (43340603..43391174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (43477229..43527777)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33743 Neighboring gene predicted gene 10373 Neighboring gene STARR-positive B cell enhancer mm9_chr15:43308481-43308782 Neighboring gene STARR-seq mESC enhancer starr_38553 Neighboring gene STARR-seq mESC enhancer starr_38554 Neighboring gene predicted gene, 53880 Neighboring gene predicted gene, 41316 Neighboring gene STARR-seq mESC enhancer starr_38556 Neighboring gene STARR-seq mESC enhancer starr_38557 Neighboring gene STARR-seq mESC enhancer starr_38558 Neighboring gene STARR-seq mESC enhancer starr_38559 Neighboring gene SUMO-conjugating enzyme UBC9 pseudogene Neighboring gene transmembrane protein 74

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane. Dreger M, et al. Proc Natl Acad Sci U S A, 2001 Oct 9. PMID 11593002, Free PMC Article
    2. The ER membrane protein complex is a transmembrane domain insertase. Guna A, et al. Science, 2018 Jan 26. PMID 29242231, Free PMC Article
    3. High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Ehringer MA, et al. Mamm Genome, 2001 Aug. PMID 11471062
    4. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Wang X, et al. Cell, 2006 Nov 17. PMID 17110338
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to membrane insertase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of EMC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extrinsic component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extrinsic component of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 2
    Names
    TPR repeat protein 35
    tetratricopeptide repeat domain 35
    tetratricopeptide repeat protein 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418323.1 → NP_001405252.1  ER membrane protein complex subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC099614, AC099621

    2. NM_001418325.1 → NP_001405254.1  ER membrane protein complex subunit 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC099614, AC099621

    3. NM_001418326.1 → NP_001405255.1  ER membrane protein complex subunit 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC099614, AC099621

    4. NM_025736.3 → NP_080012.1  ER membrane protein complex subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_080012.1

      Status: VALIDATED

      Source sequence(s)
      AC099614, AC099621
      Consensus CDS
      CCDS27453.1
      UniProtKB/Swiss-Prot
      Q925K1, Q9CRD2
      UniProtKB/TrEMBL
      Q6A0D1
      Related
      ENSMUSP00000022962.7, ENSMUST00000022962.8
      Conserved Domains (4) summary
      sd00006
      Location:120 → 150
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:156 → 222
      TPR_11; TPR repeat
      pfam13432
      Location:62 → 121
      TPR_16; Tetratricopeptide repeat
      pfam14559
      Location:99 → 164
      TPR_19; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      43340603..43391174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004938861.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRD2.1 GenPept UniProtKB/Swiss-Prot:Q9CRD2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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