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    Txndc2 thioredoxin domain containing 2 (spermatozoa) [ Mus musculus (house mouse) ]

    Gene ID: 213272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Txndc2provided by MGI
    Official Full Name
    thioredoxin domain containing 2 (spermatozoa)provided by MGI
    Primary source
    MGI:MGI:2389312
    See related
    Ensembl:ENSMUSG00000050612 AllianceGenome:MGI:2389312
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trx4; Sptrx1; Sptrx-1
    Summary
    Enables protein disulfide isomerase activity. Acts upstream of or within cellular response to reactive oxygen species and flagellated sperm motility. Located in sperm flagellum. Orthologous to human TXNDC2 (thioredoxin domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 67.4) See more
    Orthologs
    human all
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    Genomic context

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    See Txndc2 in Genome Data Viewer
    Location:
    17 E1.1; 17 34.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (65944498..65955871, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65637505..65648874, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene vesicle-associated membrane protein, associated protein A Neighboring gene predicted gene, 35477 Neighboring gene STARR-seq mESC enhancer starr_43016 Neighboring gene RAB31, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_43017 Neighboring gene STARR-seq mESC enhancer starr_43022 Neighboring gene STARR-seq mESC enhancer starr_43025 Neighboring gene protein phosphatase 4, regulatory subunit 1 Neighboring gene STARR-seq mESC enhancer starr_43027

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Developmental expression of spermatid-specific thioredoxin-1 protein: transient association to the longitudinal columns of the fibrous sheath during sperm tail formation. Yu Y, et al. Biol Reprod, 2002 Nov. PMID 12390887
    2. Cloning, expression and characterization of mouse spermatid specific thioredoxin-1 gene and protein. Jiménez A, et al. Mol Hum Reprod, 2002 Aug. PMID 12149401
    3. Absolute mRNA levels and transcriptional regulation of the mouse testis-specific thioredoxins. Jiménez A, et al. Biochem Biophys Res Commun, 2005 Apr 29. PMID 15781233
    4. Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Smith TB, et al. Free Radic Biol Med, 2013 Dec. PMID 23707457
    5. Expression of Arnt and Arnt2 mRNA in developing murine tissues. Aitola MH, et al. J Histochem Cytochem, 2003 Jan. PMID 12502753

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Txndc2 and Txndc3 are critically important in protecting spermatozoa against the increases in oxidative stress associated with paternal age.
      Title: Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to reactive oxygen species IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within flagellated sperm motility IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in outer dense fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thioredoxin domain-containing protein 2
    Names
    spermatid-specific thioredoxin 1
    thioredoxin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146002.2 → NP_001139474.1  thioredoxin domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166058
      Consensus CDS
      CCDS50165.1
      UniProtKB/Swiss-Prot
      Q6P902, Q8CJD1
      UniProtKB/TrEMBL
      H7BX21
      Related
      ENSMUSP00000054909.6, ENSMUST00000050236.7
      Conserved Domains (2) summary
      PTZ00449
      Location:126 → 395
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd02947
      Location:454 → 546
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

    2. NM_001404092.1 → NP_001391021.1  thioredoxin domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166058
      UniProtKB/Swiss-Prot
      Q6P902, Q8CJD1
      UniProtKB/TrEMBL
      A0A3B2W416

    3. NM_001404098.1 → NP_001391027.1  thioredoxin domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166058
      UniProtKB/Swiss-Prot
      Q6P902, Q8CJD1
      UniProtKB/TrEMBL
      A0A3B2W416

    4. NM_153519.3 → NP_705739.2  thioredoxin domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_705739.2

      Status: VALIDATED

      Source sequence(s)
      AC166058
      Consensus CDS
      CCDS89136.1
      UniProtKB/Swiss-Prot
      Q6P902, Q8CJD1
      UniProtKB/TrEMBL
      A0A3B2W416
      Related
      ENSMUSP00000156697.2, ENSMUST00000233702.2
      Conserved Domains (2) summary
      PTZ00449
      Location:119 → 388
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd02947
      Location:447 → 539
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      65944498..65955871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246354.4 → XP_011244656.1  thioredoxin domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011244656.1

      UniProtKB/Swiss-Prot
      Q6P902, Q8CJD1
      UniProtKB/TrEMBL
      A0A3B2W416
      Conserved Domains (2) summary
      PTZ00449
      Location:119 → 388
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd02947
      Location:447 → 539
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P902.1 GenPept UniProtKB/Swiss-Prot:Q6P902

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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