Fpgt fucose-1-phosphate guanylyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fpgtprovided by MGI
Official Full Name: fucose-1-phosphate guanylyltransferaseprovided by MGI
Primary source: MGI:MGI:1922790
See related: Ensembl:ENSMUSG00000053870 AllianceGenome:MGI:1922790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700016E03Rik
Summary: Enables fucose-1-phosphate guanylyltransferase activity. Involved in GDP-L-fucose salvage and L-fucose metabolic process. Predicted to be located in cytoplasm. Orthologous to human FPGT (fucose-1-phosphate guanylyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 4.1), cerebellum adult (RPKM 3.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H4; 3 79.53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (154790552..154799024, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (155084915..155093387, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data identified Tnni3k, Fpgt and H28 as likely likely candidates for Vms1.
Title: Quantitative trait locus analysis, pathway analysis, and consomic mapping show genetic variants of Tnni3k, Fpgt, or H28 control susceptibility to viral myocarditis.
cloning, expression and tissue distribution of murine L-fucokinase and GDP-L-fucose pyrophosphorylase
Title: Cloning and expression of murine enzymes involved in the salvage pathway of GDP-L-fucose.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables fucose-1-phosphate guanylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables fucose-1-phosphate guanylyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GDP-L-fucose salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in L-fucose metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fucose-1-phosphate guanylyltransferase

Names: GDP-L-fucose diphosphorylase; GDP-L-fucose pyrophosphorylase

NP_083606.2

EC 2.7.7.30

XP_006502296.1

EC 2.7.7.30

XP_011238570.1

EC 2.7.7.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029330.2 → NP_083606.2 fucose-1-phosphate guanylyltransferase

See identical proteins and their annotated locations for NP_083606.2

Status: VALIDATED

Source sequence(s)

AK045369, BC110551, BY670613

Consensus CDS

CCDS38681.1

UniProtKB/Swiss-Prot

G5E8F4, Q2TB53, Q712G7, Q8C1A2

Related

ENSMUSP00000068939.5, ENSMUST00000066568.6

Conserved Domains (2) summary

pfam07959
Location:106 → 523

Fucokinase; L-fucokinase

cl00160
Location:392 → 438

LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...