Guca2a guanylate cyclase activator 2a (guanylin) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Guca2aprovided by MGI
Official Full Name: guanylate cyclase activator 2a (guanylin)provided by MGI
Primary source: MGI:MGI:102738
See related: Ensembl:ENSMUSG00000023247 AllianceGenome:MGI:102738
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Guca2
Summary: Predicted to enable guanylate cyclase activator activity. Predicted to be located in extracellular region. Is expressed in several structures, including Meckel's cartilage; axial skeleton; esophagus; ganglia; and lower urinary tract. Orthologous to human GUCA2A (guanylate cyclase activator 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 1725.5), large intestine adult (RPKM 563.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.1; 4 55.47 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (119494929..119496662)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (119637732..119639465)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes.
Title: Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.
guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage
Title: Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.
act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes
Title: Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor.
These findings suggest that guanylin deficiency causes basal chloride secretion and reduced responsiveness to heat stable enterotoxin (STa) in mouse proximal colon.
Title: Effect of secretagogues and pH on intestinal transport in guanylin-deficient mice.
existence of two signaling pathways for guanylin peptides in principal cells of mouse cortical collecting duct of kidney
Title: Uroguanylin and guanylin regulate transport of mouse cortical collecting duct independent of guanylate cyclase C.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanylate cyclase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activator activity	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activator activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanylin

Names: guanylate cyclase activator 2 (guanylin 2, intestinal, heatstable)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.