Ccl24 C-C motif chemokine ligand 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccl24provided by MGI
Official Full Name: C-C motif chemokine ligand 24provided by MGI
Primary source: MGI:MGI:1928953
See related: Ensembl:ENSMUSG00000004814 AllianceGenome:MGI:1928953
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CKb-6; MPIF-2; Scya24
Summary: Enables cytokine activity. Involved in positive regulation of angiogenesis and positive regulation of inflammatory response. Acts upstream of or within chemotaxis and positive regulation of eosinophil migration. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in asthma and rhinitis. Orthologous to human CCL24 (C-C motif chemokine ligand 24). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in mammary gland adult (RPKM 5.0), liver E18 (RPKM 4.5) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 75.28 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (135598789..135601977, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (135569935..135573123, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis.
Title: CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis.
CCL24 Protects Renal Function by Controlling Inflammation in Podocytes.
Title: CCL24 Protects Renal Function by Controlling Inflammation in Podocytes.
M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis.
Title: M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis.
the increased airway eosinophils and mucous cell metaplasia in house dust mite-challenged Cd163-/- mice are mediated by augmented CCL24 production
Title: A CCL24-dependent pathway augments eosinophilic airway inflammation in house dust mite-challenged Cd163(-/-) mice.
TPL-2-regulated Ccl24 in CD11c+CD11b+ cells prevents accelerated type-2 mediated immunity to H. polygyrus.
Title: TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus.
this study shows that TPL-2 inhibits Ccl24 expression in lung dendritic cells, and blockade of Ccl24 prevents the exaggerated airway eosinophilia and lung inflammation in mice given house dust mites-pulsed Map3k8-/- dendritic cells
Title: Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells.
production in M-CSF-induced bone marrow-derived macrophages is synergistically induced by IL-4 and IL-10
Title: IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration.
Autologous transfer of peritoneal macrophages in to the airways of asthmatic mice reduces eotaxin production.
Title: Reduction of eotaxin production and eosinophil recruitment by pulmonary autologous macrophage transfer in a cockroach allergen-induced asthma model.
Data indicate that eotaxin 2 (CCL-24), which is known to influence eosinophil migration, was highly up-regulated in broncho-alveolar macrophages (BAMs).
Title: Broncho-alveolar macrophages express chemokines associated with leukocyte migration in a mouse model of asthma.
The oesophageal production of CCL24 upon IL-13 stimulation is sufficient to promote eosinophil migration.
Title: Interleukin-13 directly promotes oesophagus production of CCL11 and CCL24 and the migration of eosinophils.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR3 chemokine receptor binding	IEA Inferred from Electronic Annotation more info
enables CCR3 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IEA Inferred from Electronic Annotation more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in eosinophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in eosinophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of eosinophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-C motif chemokine 24

Names: CC chemokine CCL24; chemokine (C-C motif) ligand 24; eosinophil chemotactic protein 2; eotaxin-2; small-inducible cytokine A24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356630.1 → NP_001343559.1 C-C motif chemokine 24 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC083858, BC065389

Consensus CDS

CCDS19742.1

UniProtKB/Swiss-Prot

Q9JKC0

UniProtKB/TrEMBL

Q3U0A4

Related

ENSMUSP00000144002.2, ENSMUST00000201401.2

Conserved Domains (1) summary

cd00272
Location:33 → 90

Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...
NM_019577.5 → NP_062523.1 C-C motif chemokine 24 precursor

See identical proteins and their annotated locations for NP_062523.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC083858, AK009718, BC065389, BX524006

Consensus CDS

CCDS19742.1

UniProtKB/Swiss-Prot

Q9JKC0

UniProtKB/TrEMBL

Q3U0A4

Related

ENSMUSP00000004936.7, ENSMUST00000004936.10

Conserved Domains (1) summary

cd00272
Location:33 → 90

Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

135598789..135601977 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504444.3 → XP_006504507.1 C-C motif chemokine 24 isoform X1

See identical proteins and their annotated locations for XP_006504507.1

UniProtKB/Swiss-Prot

Q9JKC0

UniProtKB/TrEMBL

Q3U0A4

Conserved Domains (1) summary

cd00272
Location:33 → 90

Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...