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    Adam5 a disintegrin and metallopeptidase domain 5 [ Mus musculus (house mouse) ]

    Gene ID: 11499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam5provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 5provided by MGI
    Primary source
    MGI:MGI:104730
    See related
    Ensembl:ENSMUSG00000031554 AllianceGenome:MGI:104730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tMDCII; tMDC II
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
    Expression
    Restricted expression toward testis adult (RPKM 104.0) See more
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    Genomic context

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    See Adam5 in Genome Data Viewer
    Location:
    8 A2; 8 13.26 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25217109..25314385, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (24727093..24824369, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 18 Neighboring gene predicted gene, 51566 Neighboring gene predicted gene, 26208 Neighboring gene ADAM metallopeptidase domain 3 Neighboring gene STARR-seq mESC enhancer starr_20948 Neighboring gene a disintegrin and metallopeptidase domain 32 Neighboring gene STARR-seq mESC enhancer starr_20951 Neighboring gene STARR-seq mESC enhancer starr_20952 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene STARR-positive B cell enhancer mm9_chr8:26127373-26127674

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice. Li W, et al. J Mol Cell Biol, 2013 Oct. PMID 23969891
    2. Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. Ballock RT, et al. J Cell Physiol, 1994 May. PMID 8163572
    3. Expression and relationship of male reproductive ADAMs in mouse. Kim T, et al. Biol Reprod, 2006 Apr. PMID 16407499
    4. ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. Wolfsberg TG, et al. Dev Biol, 1995 May. PMID 7750654
    5. A family of cellular proteins related to snake venom disintegrins. Weskamp G, et al. Proc Natl Acad Sci U S A, 1994 Mar 29. PMID 8146185, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 5
    Names
    a disintegrin and metalloprotease domain (ADAM) 5
    transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272057.1 → NP_001258986.1  disintegrin and metalloproteinase domain-containing protein 5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001258986.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several exons and contains an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 3.
      Source sequence(s)
      AK161262, BC094237
      Consensus CDS
      CCDS85515.1
      UniProtKB/TrEMBL
      F6S1B5
      Related
      ENSMUSP00000147290.2, ENSMUST00000209935.2
      Conserved Domains (5) summary
      smart00050
      Location:397 → 473
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:475 → 618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:185 → 376
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:185 → 378
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:35 → 141
      Pep_M12B_propep; Reprolysin family propeptide

    2. NM_001272058.1 → NP_001258987.1  disintegrin and metalloproteinase domain-containing protein 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001258987.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 3.
      Source sequence(s)
      AK016574, AK161262, AK161415
      Consensus CDS
      CCDS72107.1
      UniProtKB/Swiss-Prot
      Q3TTE0
      Related
      ENSMUSP00000052661.8, ENSMUST00000050300.15
      Conserved Domains (5) summary
      smart00050
      Location:397 → 473
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:475 → 618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:185 → 376
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:185 → 378
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:35 → 141
      Pep_M12B_propep; Reprolysin family propeptide

    3. NM_001272059.1 → NP_001258988.1  disintegrin and metalloproteinase domain-containing protein 5 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two consecutive exons in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (4) may undergo proteolytic processing similar to isoform 3.
      Source sequence(s)
      AK161262, AK161415
      UniProtKB/TrEMBL
      F6S1B5
      Related
      ENSMUSP00000121272.2, ENSMUST00000132180.8
      Conserved Domains (5) summary
      smart00050
      Location:397 → 473
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:475 → 618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:185 → 376
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:185 → 378
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:35 → 141
      Pep_M12B_propep; Reprolysin family propeptide

    4. NM_007401.3 → NP_031427.2  disintegrin and metalloproteinase domain-containing protein 5 isoform 3 preproprotein

      See identical proteins and their annotated locations for NP_031427.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK161262, BC094237
      Consensus CDS
      CCDS52525.1
      UniProtKB/Swiss-Prot
      Q3TTE0, Q3TTE2, Q52KQ5, Q60623, Q60816, Q8CDV5, Q9D4F0
      Related
      ENSMUSP00000112422.2, ENSMUST00000118419.2
      Conserved Domains (5) summary
      smart00050
      Location:397 → 473
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:475 → 618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:185 → 376
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:185 → 378
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:35 → 141
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      25217109..25314385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242115.1 → XP_011240417.1  disintegrin and metalloproteinase domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011240417.1

      UniProtKB/TrEMBL
      F6S1B5
      Conserved Domains (4) summary
      smart00050
      Location:397 → 473
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:475 → 618
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:185 → 378
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:37 → 142
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_006508985.2 → XP_006509048.1  disintegrin and metalloproteinase domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006509048.1

      UniProtKB/TrEMBL
      F6S1B5
      Conserved Domains (4) summary
      smart00050
      Location:397 → 473
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:475 → 618
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:185 → 378
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:37 → 142
      Pep_M12B_propep; Reprolysin family propeptide
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TTE0.1 GenPept UniProtKB/Swiss-Prot:Q3TTE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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