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    Ankzf1 ankyrin repeat and zinc finger domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 52231, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ankzf1provided by MGI
    Official Full Name
    ankyrin repeat and zinc finger domain containing 1provided by MGI
    Primary source
    MGI:MGI:1098746
    See related
    Ensembl:ENSMUSG00000026199 AllianceGenome:MGI:1098746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Ertd161e; 1300008P06Rik; 2810025E10Rik
    Summary
    Predicted to enable RNA endonuclease activity and catalytic activity, acting on a tRNA. Predicted to be involved in cellular response to hydrogen peroxide; proteolysis involved in protein catabolic process; and rescue of stalled ribosome. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Orthologous to human ANKZF1 (ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.3), kidney adult (RPKM 12.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankzf1 in Genome Data Viewer
    Location:
    1 C4; 1 38.62 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75168794..75176031)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75192160..75199387)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B member 6 Neighboring gene STARR-positive B cell enhancer ABC_E8982 Neighboring gene autophagy related 9A Neighboring gene STARR-positive B cell enhancer ABC_E321 Neighboring gene galactosidase, beta 1-like Neighboring gene serine/threonine kinase 16 Neighboring gene STARR-positive B cell enhancer ABC_E3282 Neighboring gene tubulin, alpha 4A Neighboring gene RIKEN cDNA A630095N17 gene Neighboring gene STARR-seq mESC enhancer starr_01353

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NAT10-mediated ac(4)C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1. Miao D, et al. Cancer Commun (Lond), 2024 Mar. PMID 38407929, Free PMC Article
    2. A stress-responsive system for mitochondrial protein degradation. Heo JM, et al. Mol Cell, 2010 Nov 12. PMID 21070972, Free PMC Article
    3. Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Ling KH, et al. Genome Biol, 2009. PMID 19799774, Free PMC Article
    4. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NAT10-mediated ac[4]C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1.
      Title: NAT10-mediated ac(4)C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity, acting on a tRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables catalytic activity, acting on a tRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hydrogen peroxide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA endonuclease ANKZF1
    Names
    ankyrin repeat and zinc finger domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267620.1 → NP_001254549.1  tRNA endonuclease ANKZF1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons but includes an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AI425962, BC051449, CN717456
      Conserved Domains (2) summary
      smart00451
      Location:93 → 127
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:98 → 120
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001404903.1 → NP_001391832.1  tRNA endonuclease ANKZF1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    3. NM_001404904.1 → NP_001391833.1  tRNA endonuclease ANKZF1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    4. NM_001404905.1 → NP_001391834.1  tRNA endonuclease ANKZF1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    5. NM_001404906.1 → NP_001391835.1  tRNA endonuclease ANKZF1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    6. NM_001404907.1 → NP_001391836.1  tRNA endonuclease ANKZF1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    7. NM_026187.5 → NP_080463.3  tRNA endonuclease ANKZF1 isoform 1

      See identical proteins and their annotated locations for NP_080463.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC166150, AW536302, BU054541, BU755641, CN717456, CX232548, DV062487
      Consensus CDS
      CCDS56632.1
      UniProtKB/Swiss-Prot
      B9EKG0, Q80UU1, Q9CZF5
      UniProtKB/TrEMBL
      J3QM81
      Related
      ENSMUSP00000136163.2, ENSMUST00000152233.9
      Conserved Domains (4) summary
      cd00204
      Location:520 → 600
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00020
      Location:98 → 120
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12796
      Location:520 → 587
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:556 → 587
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_051998.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC166150, BU755641, CN717456
      Related
      ENSMUST00000145459.9

    2. NR_051999.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' region and several exons in the 3' region, but includes an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI425962, AK084573, CN717456
      Related
      ENSMUST00000134378.9

    3. NR_175880.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    4. NR_175881.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    5. NR_175882.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    6. NR_175883.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    7. NR_175884.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    8. NR_175885.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    9. NR_175886.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    10. NR_175887.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    11. NR_175888.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166150, FQ976561

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75168794..75176031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496507.2 → XP_006496570.1  tRNA endonuclease ANKZF1 isoform X1

      UniProtKB/Swiss-Prot
      B9EKG0, Q80UU1, Q9CZF5
      Conserved Domains (7) summary
      PTZ00322
      Location:557 → 629
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00020
      Location:98 → 120
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00045
      Location:556 → 587
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:557 → 587
      Ank; Ankyrin repeat
      pfam12796
      Location:520 → 587
      Ank_2; Ankyrin repeats (3 copies)
      pfam18716
      Location:773 → 813
      VATC; Vms1-associating treble clef domain
      pfam18826
      Location:231 → 375
      bVLRF1; bacteroidetes VLRF1 release factor

    2. XM_036152358.1 → XP_036008251.1  tRNA endonuclease ANKZF1 isoform X4

      Conserved Domains (6) summary
      PTZ00322
      Location:264 → 336
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:263 → 294
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:264 → 294
      Ank; Ankyrin repeat
      pfam12796
      Location:227 → 294
      Ank_2; Ankyrin repeats (3 copies)
      pfam18716
      Location:416 → 453
      VATC; Vms1-associating treble clef domain
      pfam18826
      Location:1 → 82
      bVLRF1; bacteroidetes VLRF1 release factor

    3. XM_036152357.1 → XP_036008250.1  tRNA endonuclease ANKZF1 isoform X2

      Conserved Domains (6) summary
      PTZ00322
      Location:323 → 395
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:322 → 353
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:323 → 353
      Ank; Ankyrin repeat
      pfam12796
      Location:286 → 353
      Ank_2; Ankyrin repeats (3 copies)
      pfam18716
      Location:539 → 578
      VATC; Vms1-associating treble clef domain
      pfam18826
      Location:1 → 141
      bVLRF1; bacteroidetes VLRF1 release factor

    4. XM_011238696.2 → XP_011236998.1  tRNA endonuclease ANKZF1 isoform X2

      See identical proteins and their annotated locations for XP_011236998.1

      Conserved Domains (6) summary
      PTZ00322
      Location:323 → 395
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:322 → 353
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:323 → 353
      Ank; Ankyrin repeat
      pfam12796
      Location:286 → 353
      Ank_2; Ankyrin repeats (3 copies)
      pfam18716
      Location:539 → 578
      VATC; Vms1-associating treble clef domain
      pfam18826
      Location:1 → 141
      bVLRF1; bacteroidetes VLRF1 release factor

    5. XM_030255491.1 → XP_030111351.1  tRNA endonuclease ANKZF1 isoform X3

      Conserved Domains (6) summary
      PTZ00322
      Location:264 → 336
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:263 → 294
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:264 → 294
      Ank; Ankyrin repeat
      pfam12796
      Location:227 → 294
      Ank_2; Ankyrin repeats (3 copies)
      pfam18716
      Location:480 → 520
      VATC; Vms1-associating treble clef domain
      pfam18826
      Location:1 → 82
      bVLRF1; bacteroidetes VLRF1 release factor

    6. XM_036152354.1 → XP_036008247.1  tRNA endonuclease ANKZF1 isoform X2

      Conserved Domains (6) summary
      PTZ00322
      Location:323 → 395
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:322 → 353
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:323 → 353
      Ank; Ankyrin repeat
      pfam12796
      Location:286 → 353
      Ank_2; Ankyrin repeats (3 copies)
      pfam18716
      Location:539 → 578
      VATC; Vms1-associating treble clef domain
      pfam18826
      Location:1 → 141
      bVLRF1; bacteroidetes VLRF1 release factor

    7. XM_036152348.1 → XP_036008241.1  tRNA endonuclease ANKZF1 isoform X2

      Conserved Domains (6) summary
      PTZ00322
      Location:323 → 395
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:322 → 353
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:323 → 353
      Ank; Ankyrin repeat
      pfam12796
      Location:286 → 353
      Ank_2; Ankyrin repeats (3 copies)
      pfam18716
      Location:539 → 578
      VATC; Vms1-associating treble clef domain
      pfam18826
      Location:1 → 141
      bVLRF1; bacteroidetes VLRF1 release factor

    RNA

    1. XR_004933624.1 RNA Sequence

      Related
      ENSMUST00000131788.9

    2. XR_003956227.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UU1.2 GenPept UniProtKB/Swiss-Prot:Q80UU1

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