Pou2f1 POU domain, class 2, transcription factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pou2f1provided by MGI
Official Full Name: POU domain, class 2, transcription factor 1provided by MGI
Primary source: MGI:MGI:101898
See related: Ensembl:ENSMUSG00000026565 AllianceGenome:MGI:101898
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oct1; Otf1; NF-A1; Oct-1; Otf-1; 2810482H01Rik
Summary: Enables chromatin binding activity and sequence-specific DNA binding activity. Acts upstream of or within lens induction in camera-type eye; olfactory placode formation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including cerebellum; embryo ectoderm; genitourinary system; lung; and sensory organ. Orthologous to human POU2F1 (POU class 2 homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 4.4), whole brain E14.5 (RPKM 3.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.3; 1 73.21 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (165692719..165830318, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (165865150..166002749, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression.
Title: Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression.
Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification.
Title: Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification.
5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt's Lymphoma Cell Culture.
Title: 5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt's Lymphoma Cell Culture.
LncRNA NEAT1 Promotes Inflammatory Response in Sepsis via the miR-31-5p/POU2F1 Axis.
Title: LncRNA NEAT1 Promotes Inflammatory Response in Sepsis via the miR-31-5p/POU2F1 Axis.
OBF1 and Oct factors control the germinal center transcriptional program.
Title: OBF1 and Oct factors control the germinal center transcriptional program.
Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway.
Title: Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway.
Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.
Title: Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.
Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina.
Title: Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina.
In MLL-AF9-driven mouse models, partial loss of Oct1 protects from myeloid leukemia. Complete Oct1 loss completely suppresses leukemia but results in lethality from bone marrow failure. Loss of Oct1 in normal hematopoietic transplants results in superficially normal long-term reconstitution; however, animals become acutely sensitive to 5-fluorouracil, indicating that Oct1 is dispensable for normal hematopoiesis.
Title: Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia.
Oct1-deficient T cells mitigated reduced infiltrating T cells and cytokine production in an autoimmune neuroinflammation disease model.
Title: T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW552088 (e-PCR)
- UniSTS:178499

Pou2f1 (e-PCR), detects polymorphism
- UniSTS:527499

X68362 (e-PCR)
- UniSTS:158879

Pou2f1 (e-PCR), detects polymorphism
- UniSTS:108991

L03353 (e-PCR)
- UniSTS:163269

PMC321444P1 (e-PCR)
- UniSTS:273111

Cd3z (e-PCR), detects polymorphism
- UniSTS:141281

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lens induction in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within olfactory placode formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: POU domain, class 2, transcription factor 1

Names: octamer-binding protein 1; octamer-binding transcription factor 1; ubiquitous transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368808.1 → NP_001355737.1 POU domain, class 2, transcription factor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC093371

UniProtKB/Swiss-Prot

P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6

UniProtKB/TrEMBL

A0A0A0MQE0

Conserved Domains (2) summary

smart00352
Location:281 → 355

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:385 → 439

Homeobox; Homeobox domain
NM_011137.3 → NP_035267.2 POU domain, class 2, transcription factor 1 isoform A

See identical proteins and their annotated locations for NP_035267.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (A).

Source sequence(s)

AC093371, AK028237

Consensus CDS

CCDS35760.1

UniProtKB/TrEMBL

A0A0A0MQE0, A0A0R4J1Z4

Related

ENSMUSP00000124738.2, ENSMUST00000160260.9

Conserved Domains (2) summary

smart00352
Location:304 → 378

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:408 → 461

Homeobox; Homeobox domain
NM_198932.3 → NP_945150.2 POU domain, class 2, transcription factor 1 isoform Z

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform Z, which is shorter than isoform A.

Source sequence(s)

AC093371

Consensus CDS

CCDS48430.1

UniProtKB/TrEMBL

E9Q6Z8, I1E4X2

Related

ENSMUSP00000125444.2, ENSMUST00000160908.8

Conserved Domains (2) summary

smart00352
Location:304 → 378

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:408 → 461

Homeobox; Homeobox domain
NM_198933.3 → NP_945151.2 POU domain, class 2, transcription factor 1 isoform L

See identical proteins and their annotated locations for NP_945151.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate 5' terminal exon and lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform L, which is shorter and has a distinct N-terminus, compared to isoform A.

Source sequence(s)

AC093371

Consensus CDS

CCDS15444.1

UniProtKB/TrEMBL

A0A0A0MQE0

Related

ENSMUSP00000064000.6, ENSMUST00000069609.12

Conserved Domains (2) summary

smart00352
Location:293 → 367

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:397 → 450

Homeobox; Homeobox domain
NM_198934.3 → NP_945152.2 POU domain, class 2, transcription factor 1 isoform B

See identical proteins and their annotated locations for NP_945152.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate 5' terminal exon, compared to variant 1. It encodes isoform B, which is shorter and has a distinct N-terminus, compared to isoform A.

Source sequence(s)

AC093371

Consensus CDS

CCDS35761.1

UniProtKB/TrEMBL

A0A0A0MQE0, F8VQL7

Related

ENSMUSP00000107056.3, ENSMUST00000111427.9

Conserved Domains (2) summary

smart00352
Location:293 → 367

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:397 → 450

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

165692719..165830318 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252286.1 → XP_030108146.1 POU domain, class 2, transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6

UniProtKB/TrEMBL

A0A0A0MQE0

Conserved Domains (2) summary

smart00352
Location:281 → 355

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:385 → 439

Homeobox; Homeobox domain
XM_006496704.4 → XP_006496767.1 POU domain, class 2, transcription factor 1 isoform X1

See identical proteins and their annotated locations for XP_006496767.1

UniProtKB/Swiss-Prot

P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6

UniProtKB/TrEMBL

A0A0A0MQE0

Conserved Domains (2) summary

smart00352
Location:281 → 355

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:385 → 439

Homeobox; Homeobox domain
XM_030252287.2 → XP_030108147.1 POU domain, class 2, transcription factor 1 isoform X2

UniProtKB/TrEMBL

A0A0A0MQE0

Related

ENSMUSP00000107057.5, ENSMUST00000111429.11

Conserved Domains (2) summary

smart00352
Location:281 → 355

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:385 → 439

Homeobox; Homeobox domain
XM_036162785.1 → XP_036018678.1 POU domain, class 2, transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6

UniProtKB/TrEMBL

A0A0A0MQE0

Conserved Domains (2) summary

smart00352
Location:281 → 355

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:385 → 439

Homeobox; Homeobox domain
XM_017319360.3 → XP_017174849.1 POU domain, class 2, transcription factor 1 isoform X2

UniProtKB/TrEMBL

A0A0A0MQE0

Conserved Domains (2) summary

smart00352
Location:281 → 355

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:385 → 439

Homeobox; Homeobox domain