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    Uck2 uridine-cytidine kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 80914, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Uck2provided by MGI
    Official Full Name
    uridine-cytidine kinase 2provided by MGI
    Primary source
    MGI:MGI:1931744
    See related
    Ensembl:ENSMUSG00000026558 AllianceGenome:MGI:1931744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UK; UMK; Umpk; TSA903
    Summary
    Predicted to enable cytidine kinase activity; identical protein binding activity; and uridine kinase activity. Predicted to be involved in CTP salvage and UMP salvage. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; cranium; integumental system; nervous system; and sensory organ. Orthologous to human UCK2 (uridine-cytidine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 18.8), CNS E11.5 (RPKM 15.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uck2 in Genome Data Viewer
    Location:
    1 H2.3; 1 74.61 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167050464..167112657, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167222895..167285933, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33668 Neighboring gene STARR-seq mESC enhancer starr_02941 Neighboring gene TSPY-like 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02942 Neighboring gene STARR-positive B cell enhancer ABC_E7773 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:169172446-169172703 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:169175381-169175490 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:169175492-169175800 Neighboring gene predicted gene, 51816 Neighboring gene STARR-seq mESC enhancer starr_02945 Neighboring gene predicted gene, 46170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:169214019-169214206 Neighboring gene microRNA 6347 Neighboring gene predicted gene 2453

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Uridine-cytidine kinase 2 potentiates the mutagenic influence of the antiviral β-d-N4-hydroxycytidine. Xu Z, et al. Nucleic Acids Res, 2023 Dec 11. PMID 37953355, Free PMC Article
    2. The pivotal role of uridine-cytidine kinases in pyrimidine metabolism and activation of cytotoxic nucleoside analogues in neuroblastoma. van Kuilenburg AB, et al. Biochim Biophys Acta, 2016 Sep. PMID 27239701
    3. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Van Rompay AR, et al. Mol Pharmacol, 2001 May. PMID 11306702
    4. Lifelong persistence of nuclear RNAs in the mouse brain. Zocher S, et al. Science, 2024 Apr 5. PMID 38574132, Free PMC Article
    5. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Uridine-cytidine kinase 2 potentiates the mutagenic influence of the antiviral beta-d-N4-hydroxycytidine.
      Title: Uridine-cytidine kinase 2 potentiates the mutagenic influence of the antiviral β-d-N4-hydroxycytidine.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytidine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables uridine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables uridine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CTP salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in UMP salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uridine-cytidine kinase 2
    Names
    UCK 2
    cytidine monophosphokinase 2
    uridine monophosphate kinase 2
    uridine monophosphokinase 2
    NP_001404848.1
    NP_001404849.1
    NP_001404850.1
    NP_001404851.1
    NP_001404852.1
    NP_001404853.1
    NP_109649.1
    XP_030099588.1
    XP_036010343.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417919.1 → NP_001404848.1  uridine-cytidine kinase 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC142244
      Related
      ENSMUSP00000027839.10, ENSMUST00000027839.14

    2. NM_001417920.1 → NP_001404849.1  uridine-cytidine kinase 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC142244

    3. NM_001417921.1 → NP_001404850.1  uridine-cytidine kinase 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC142244

    4. NM_001417922.1 → NP_001404851.1  uridine-cytidine kinase 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC142244

    5. NM_001417923.1 → NP_001404852.1  uridine-cytidine kinase 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC142244

    6. NM_001417924.1 → NP_001404853.1  uridine-cytidine kinase 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC142244

    7. NM_030724.4 → NP_109649.1  uridine-cytidine kinase 2 isoform a

      See identical proteins and their annotated locations for NP_109649.1

      Status: VALIDATED

      Source sequence(s)
      AC142244
      Consensus CDS
      CCDS15455.1
      UniProtKB/Swiss-Prot
      Q99PM9
      UniProtKB/TrEMBL
      Q543C2, Q8C476
      Related
      ENSMUSP00000060202.5, ENSMUST00000053686.9
      Conserved Domains (1) summary
      cd02023
      Location:22 → 228
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      167050464..167112657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243728.1 → XP_030099588.1  uridine-cytidine kinase 2 isoform X4

      Conserved Domains (1) summary
      cd02023
      Location:35 → 176
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    2. XM_036154450.1 → XP_036010343.1  uridine-cytidine kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A0B4J1E5
      Conserved Domains (1) summary
      cd02023
      Location:2 → 196
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PM9.1 GenPept UniProtKB/Swiss-Prot:Q99PM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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