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    Map7 microtubule-associated protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 17761, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Map7provided by MGI
    Official Full Name
    microtubule-associated protein 7provided by MGI
    Primary source
    MGI:MGI:1328328
    See related
    Ensembl:ENSMUSG00000019996 AllianceGenome:MGI:1328328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ste; mshi; mste; MAP-7; Mtap7; E-MAP-115
    Summary
    Enables signaling receptor binding activity. Involved in protein localization to plasma membrane and response to osmotic stress. Acts upstream of or within several processes, including glycosphingolipid metabolic process; male gonad development; and response to retinoic acid. Located in plasma membrane. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; nervous system; and skin. Orthologous to human MAP7 (microtubule associated protein 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 10.3), cortex adult (RPKM 7.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map7 in Genome Data Viewer
    Location:
    10 A3; 10 9.75 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (20024666..20157336)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (20148920..20281590)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25941 Neighboring gene STARR-seq mESC enhancer starr_25942 Neighboring gene peroxisomal biogenesis factor 7 Neighboring gene STARR-seq mESC enhancer starr_25943 Neighboring gene STARR-positive B cell enhancer ABC_E10597 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19659120-19659310 Neighboring gene mitogen-activated protein kinase kinase kinase 5 Neighboring gene STARR-seq mESC enhancer starr_25945 Neighboring gene STARR-positive B cell enhancer mm9_chr10:19711687-19711987 Neighboring gene STARR-positive B cell enhancer ABC_E8326 Neighboring gene STARR-positive B cell enhancer ABC_E11432 Neighboring gene STARR-seq mESC enhancer starr_25946 Neighboring gene STARR-seq mESC enhancer starr_25947 Neighboring gene STARR-seq mESC enhancer starr_25949 Neighboring gene STARR-seq mESC enhancer starr_25952 Neighboring gene RIKEN cDNA 4930405J17 gene Neighboring gene predicted gene, 51795 Neighboring gene STARR-seq mESC enhancer starr_25958 Neighboring gene ribosomal protein L32-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19977636-19977875 Neighboring gene predicted gene, 48249 Neighboring gene predicted gene, 30285 Neighboring gene microRNA 6413

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The H-mshi antigen is conserved among standard BALB/cBy, C57BL/6J, and wild-derived CAST/Ei and SPRET/Ei inbred strains of mice. Hildebrandt AL, et al. Immunogenetics, 1999 Jul. PMID 10369925
    2. MAP7 Prevents Axonal Branch Retraction by Creating a Stable Microtubule Boundary to Rescue Polymerization. Tymanskyj SR, et al. J Neurosci, 2019 Sep 4. PMID 31391261, Free PMC Article
    3. MAP7 regulates organelle transport by recruiting kinesin-1 to microtubules. Chaudhary AR, et al. J Biol Chem, 2019 Jun 28. PMID 31085585, Free PMC Article
    4. The distribution of murine 115-kDa epithelial microtubule-associated protein (E-MAP-115) during embryogenesis and in adult organs suggests a role in epithelial polarization and differentiation. Fabre-Jonca N, et al. Differentiation, 1998 Aug. PMID 9745708
    5. Microtubule-associated epithelial protein E-MAP-115 is localized in the spermatid manchette. Penttilä TL, et al. Int J Androl, 2003 Jun. PMID 12755995

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAP7 binds to the acetylated and stable region of individual microtubules and rescues microtubule polymerization in developing sensory neurons.
      Title: MAP7 Prevents Axonal Branch Retraction by Creating a Stable Microtubule Boundary to Rescue Polymerization.
    2. MAP7D2 interacts with all three kinesin-1 family members and accumulates in the proximal axon through its N-terminal microtubule-binding domain. Depletion of MAP7D2 results in reduced axonal cargo entry.
      Title: MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon.
    3. MAP7 does not alter the force exerted by a single kinesin-1 motor, but instead increases its binding rate to the microtubule
      Title: MAP7 regulates organelle transport by recruiting kinesin-1 to microtubules.
    4. identification of the microtubule-associated protein ensconsin (Ens)/microtubule-associated protein 7 (MAP7) and kinesin heavy chain (Khc)/Kif5b as essential, evolutionarily conserved regulators of myonuclear positioning in Drosophila and cultured mammalian myotubes
      Title: MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function.
    5. Complementation testing showed that one of these, Mtap7, is disrupted in mshi mice.
      Title: The male sterility and histoincompatibility (mshi) mutation in mice is a natural variant of microtubule-associated protein 7 (Mtap7).
    6. MAP7 is the TRPV4 C-terminal binding protein; alignment of a.a.798-809 of TRPV4 was important in this interaction; TRPV4 and MAP7 colocalized in lung and kidney; coexpression resulted in redistribution of TRPV4 and enhanced membrane expression of TRPV4
      Title: Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4).
    Submit: New GeneRIF Correction

    Phenotypes

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    Associated conditions

    Description Tests
    male sterility and histoincompatibility
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Leydig cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within Sertoli cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycosphingolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule bundle formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ensconsin
    Names
    epithelial microtubule-associated protein of 115 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198635.2 → NP_001185564.1  ensconsin isoform 2

      See identical proteins and their annotated locations for NP_001185564.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) has an additional segment, as compared to isoform 1.
      Source sequence(s)
      AC153845, AC158620
      Consensus CDS
      CCDS56694.1
      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      UniProtKB/TrEMBL
      D3YWN7
      Related
      ENSMUSP00000111963.4, ENSMUST00000116259.5
      Conserved Domains (1) summary
      pfam05672
      Location:458 → 610
      MAP7; MAP7 (E-MAP-115) family

    2. NM_001358787.1 → NP_001345716.1  ensconsin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AB098611, AK014575, BC052637, BY264190
      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (3) summary
      pfam03999
      Location:111 → 337
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam05672
      Location:472 → 625
      MAP7; MAP7 (E-MAP-115) family
      pfam09756
      Location:101 → 174
      DDRGK; DDRGK domain

    3. NM_001428647.1 → NP_001415576.1  ensconsin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620

    4. NM_001428648.1 → NP_001415577.1  ensconsin isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620

    5. NM_001428649.1 → NP_001415578.1  ensconsin isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620

    6. NM_001428650.1 → NP_001415579.1  ensconsin isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620

    7. NM_001428651.1 → NP_001415580.1  ensconsin isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620

    8. NM_001428652.1 → NP_001415581.1  ensconsin isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620

    9. NM_001428653.1 → NP_001415582.1  ensconsin isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620

    10. NM_001428654.1 → NP_001415583.1  ensconsin isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620

    11. NM_001428655.1 → NP_001415584.1  ensconsin isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620
      UniProtKB/TrEMBL
      A0A1L1SVB6

    12. NM_001428656.1 → NP_001415585.1  ensconsin isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620

    13. NM_008635.3 → NP_032661.2  ensconsin isoform 1

      See identical proteins and their annotated locations for NP_032661.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the dominant transcript and encodes isoform 1.
      Source sequence(s)
      AC153845, AC158620
      Consensus CDS
      CCDS87968.1
      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      UniProtKB/TrEMBL
      E9QMU3
      Related
      ENSMUSP00000020173.10, ENSMUST00000020173.16
      Conserved Domains (1) summary
      pfam05672
      Location:450 → 602
      MAP7; MAP7 (E-MAP-115) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      20024666..20157336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155666.1 → XP_036011559.1  ensconsin isoform X8

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (1) summary
      pfam05672
      Location:312 → 464
      MAP7; MAP7 (E-MAP-115) family

    2. XM_006512577.4 → XP_006512640.1  ensconsin isoform X1

      Conserved Domains (2) summary
      pfam05672
      Location:480 → 632
      MAP7; MAP7 (E-MAP-115) family
      pfam15927
      Location:111 → 180
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    3. XM_036155665.1 → XP_036011558.1  ensconsin isoform X4

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (2) summary
      pfam05672
      Location:442 → 594
      MAP7; MAP7 (E-MAP-115) family
      pfam06098
      Location:111 → 168
      Radial_spoke_3; Radial spoke protein 3

    4. XM_006512582.4 → XP_006512645.1  ensconsin isoform X6

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (2) summary
      pfam05672
      Location:434 → 586
      MAP7; MAP7 (E-MAP-115) family
      pfam15927
      Location:111 → 180
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    5. XM_036155667.1 → XP_036011560.1  ensconsin isoform X9

      Conserved Domains (1) summary
      pfam05672
      Location:274 → 426
      MAP7; MAP7 (E-MAP-115) family

    6. XM_006512584.5 → XP_006512647.1  ensconsin isoform X8

      Conserved Domains (1) summary
      pfam05672
      Location:312 → 464
      MAP7; MAP7 (E-MAP-115) family

    7. XM_006512585.5 → XP_006512648.1  ensconsin isoform X8

      See identical proteins and their annotated locations for XP_006512648.1

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (1) summary
      pfam05672
      Location:312 → 464
      MAP7; MAP7 (E-MAP-115) family

    8. XM_006512580.3 → XP_006512643.1  ensconsin isoform X3

      Conserved Domains (2) summary
      pfam05672
      Location:443 → 595
      MAP7; MAP7 (E-MAP-115) family
      pfam15927
      Location:74 → 145
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    9. XM_006512581.3 → XP_006512644.1  ensconsin isoform X5

      Conserved Domains (2) summary
      pfam05672
      Location:435 → 587
      MAP7; MAP7 (E-MAP-115) family
      pfam15927
      Location:74 → 143
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    10. XM_006512583.4 → XP_006512646.1  ensconsin isoform X7

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (2) summary
      pfam05672
      Location:421 → 573
      MAP7; MAP7 (E-MAP-115) family
      pfam15927
      Location:98 → 167
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    11. XM_006512579.4 → XP_006512642.1  ensconsin isoform X2

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (2) summary
      pfam05672
      Location:467 → 619
      MAP7; MAP7 (E-MAP-115) family
      pfam09756
      Location:88 → 161
      DDRGK; DDRGK domain

    12. XM_036155668.1 → XP_036011561.1  ensconsin isoform X10

      Conserved Domains (1) summary
      pfam05672
      Location:193 → 345
      MAP7; MAP7 (E-MAP-115) family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001198636.1: Suppressed sequence

      Description
      NM_001198636.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88735.1 GenPept UniProtKB/Swiss-Prot:O88735

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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