Kif14 kinesin family member 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif14provided by MGI
Official Full Name: kinesin family member 14provided by MGI
Primary source: MGI:MGI:1098226
See related: Ensembl:ENSMUSG00000041498 AllianceGenome:MGI:1098226
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D1Ertd367e; E130203M01
Summary: Enables several functions, including ATP binding activity; ATP hydrolysis activity; and plus-end-directed microtubule motor activity. Involved in several processes, including brain development; negative regulation of neuron apoptotic process; and regulation of myelination. Predicted to be located in several cellular components, including Flemming body; cytosol; and spindle midzone. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Predicted to colocalize with plasma membrane. Is expressed in retina. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly. Orthologous to human KIF14 (kinesin family member 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E14 (RPKM 3.3), liver E14.5 (RPKM 2.8) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 59.8 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (136394044..136483676)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (136466301..136555938)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14.
Title: Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14.
this work reveals a novel association of Kif14 overexpression with lymphoma but suggests that Kif14 does not have as prominent a role in initiating cancer in other cell types as it does in accelerating tumour development in response to other oncogenic insults.
Title: Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14.
Data provide the first evidence that Kif14 can promote tumor formation in susceptible cells in vivo
Title: Kif14 overexpression accelerates murine retinoblastoma development.
The ADP-bound form of the KIF14 motor domain reveals a dramatically opened ATP-binding pocket.
Title: KIF14 binds tightly to microtubules and adopts a rigor-like conformation.
Kif14 mutation causes severe brain malformation and hypomyelination.
Title: Kif14 mutation causes severe brain malformation and hypomyelination.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Spontaneous (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127070 (e-PCR)
- UniSTS:167269

NoName (e-PCR)
- UniSTS:234225

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell proliferation in forebrain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellar Purkinje cell layer structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellar cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellar granular layer structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of protein localization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of integrin activation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory bulb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of Rap protein signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of cell adhesion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in Flemming body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	ISO Inferred from Sequence Orthology more info	PubMed
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kinesin-like protein KIF14

Names: N-3 kinesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287179.2 → NP_001274108.1 kinesin-like protein KIF14

See identical proteins and their annotated locations for NP_001274108.1

Status: VALIDATED

Source sequence(s)

AB731728, AC122127, AC126606, AK087451

Consensus CDS

CCDS78693.1

UniProtKB/Swiss-Prot

L0N7N1

UniProtKB/TrEMBL

B2RY84

Related

ENSMUSP00000139698.2, ENSMUST00000189413.7

Conserved Domains (5) summary

cd00060
Location:838 → 935

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

TIGR02168
Location:937 → 1109

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01365
Location:392 → 743

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam05110
Location:161 → 384

AF-4; AF-4 proto-oncoprotein

pfam16183
Location:740 → 859

Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

136394044..136483676

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248046.3 → XP_011246348.1 kinesin-like protein KIF14 isoform X2

UniProtKB/TrEMBL

B2RY84

Conserved Domains (5) summary

cd00060
Location:838 → 935

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

TIGR02168
Location:937 → 1109

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01365
Location:392 → 743

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam05110
Location:161 → 384

AF-4; AF-4 proto-oncoprotein

pfam16183
Location:740 → 859

Kinesin_assoc; Kinesin-associated
XM_011248039.3 → XP_011246341.1 kinesin-like protein KIF14 isoform X1

See identical proteins and their annotated locations for XP_011246341.1

UniProtKB/TrEMBL

B2RY84

Conserved Domains (5) summary

cd00060
Location:838 → 935

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

TIGR02168
Location:937 → 1109

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01365
Location:392 → 743

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam05110
Location:161 → 384

AF-4; AF-4 proto-oncoprotein

pfam16183
Location:740 → 859

Kinesin_assoc; Kinesin-associated
XM_011248040.3 → XP_011246342.1 kinesin-like protein KIF14 isoform X1

See identical proteins and their annotated locations for XP_011246342.1

UniProtKB/TrEMBL

B2RY84

Conserved Domains (5) summary

cd00060
Location:838 → 935

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

TIGR02168
Location:937 → 1109

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01365
Location:392 → 743

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam05110
Location:161 → 384

AF-4; AF-4 proto-oncoprotein

pfam16183
Location:740 → 859

Kinesin_assoc; Kinesin-associated
XM_011248044.3 → XP_011246346.1 kinesin-like protein KIF14 isoform X1

See identical proteins and their annotated locations for XP_011246346.1

UniProtKB/TrEMBL

B2RY84

Conserved Domains (5) summary

cd00060
Location:838 → 935

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

TIGR02168
Location:937 → 1109

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01365
Location:392 → 743

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam05110
Location:161 → 384

AF-4; AF-4 proto-oncoprotein

pfam16183
Location:740 → 859

Kinesin_assoc; Kinesin-associated
XM_011248043.4 → XP_011246345.1 kinesin-like protein KIF14 isoform X1

See identical proteins and their annotated locations for XP_011246345.1

UniProtKB/TrEMBL

B2RY84

Conserved Domains (5) summary

cd00060
Location:838 → 935

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

TIGR02168
Location:937 → 1109

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01365
Location:392 → 743

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam05110
Location:161 → 384

AF-4; AF-4 proto-oncoprotein

pfam16183
Location:740 → 859

Kinesin_assoc; Kinesin-associated
XM_006529729.5 → XP_006529792.1 kinesin-like protein KIF14 isoform X3

See identical proteins and their annotated locations for XP_006529792.1

UniProtKB/Swiss-Prot

L0N7N1

UniProtKB/TrEMBL

B2RY84

Conserved Domains (5) summary

cd00060
Location:838 → 935

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

TIGR02168
Location:937 → 1109

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01365
Location:392 → 743

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam05110
Location:161 → 384

AF-4; AF-4 proto-oncoprotein

pfam16183
Location:740 → 859

Kinesin_assoc; Kinesin-associated
XM_006529730.3 → XP_006529793.2 kinesin-like protein KIF14 isoform X1

See identical proteins and their annotated locations for XP_006529793.2

UniProtKB/TrEMBL

B2RY84

Conserved Domains (5) summary

cd00060
Location:838 → 935

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

TIGR02168
Location:937 → 1109

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01365
Location:392 → 743

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam05110
Location:161 → 384

AF-4; AF-4 proto-oncoprotein

pfam16183
Location:740 → 859

Kinesin_assoc; Kinesin-associated

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001081258.1: Suppressed sequence

Description

NM_001081258.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.