Mov10l1 Mov10 like RISC complex RNA helicase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mov10l1provided by MGI
Official Full Name: Mov10 like RISC complex RNA helicase 1provided by MGI
Primary source: MGI:MGI:1891384
See related: Ensembl:ENSMUSG00000015365 AllianceGenome:MGI:1891384
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Csm; CHAMP
Summary: Enables RNA helicase activity and piRNA binding activity. Involved in several processes, including male meiosis I; regulatory ncRNA-mediated gene silencing; and spermatogenesis. Located in pi-body. Is expressed in heart and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 73. Orthologous to human MOV10L1 (Mov10 like RNA helicase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 12.7) and heart adult (RPKM 9.4) See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.49 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (88867094..88939355)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (88982891..89055152)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.
Title: yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.
The N-terminus of MOV10 also leads to increased RGG box-dependent binding to the SC1 RNA G-Quadruplex and is required for outgrowth of neurites. Lastly, we showed that FMRP has a global role in miRNA-mediated translational regulation by recruiting AGO2 to a large subset of RNAs in mouse brain.
Title: The FMRP-MOV10 complex: a translational regulatory switch modulated by G-Quadruplexes.
The data expand the landscape of MOV10 function and highlight a previously unidentified role initiated from the nucleus, suggesting that MOV10 is a versatile RNA-binding protein involved in a broader RNA regulatory network.
Title: Biological and RNA regulatory function of MOV10 in mammalian germ cells.
Conditional inactivation of the putative RNA helicase Mov10l1 in mouse spermatocytes produces a specific loss of pachytene piRNAs, significant accumulation of pachytene piRNA precursor transcripts, and unusual polar conglomeration of Piwi proteins with mitochondria. Mov10l1 is required for pachytene piRNA biogenesis.
Title: Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity.
Mutations in the conserved ATP hydrolysis motif of MOV10L1 block piRNA biogenesis and result in male sterility.
Title: Mutations in the MOV10L1 ATP Hydrolysis Motif Cause piRNA Biogenesis Failure and Male Sterility in Mice.
MOV10L1 RNA helicase activity promotes unwinding and funneling of the single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing
Title: The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing.
MOV10L1 exhibits 5'-to-3' directional RNA-unwinding activity in vitro and its RNA helicase activity is required for primary piRNA biogenesis in vivo. MOV10L1 selectively binds piRNA precursor transcripts. MOV10L1 is essential for the generation of intermediate piRNA processing fragments. piRNA precursor processing is intimately coupled with elements of local secondary structures such as G quadruplexes.
Title: The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing.
MOV10L1 is essential for the primary processing of pachytene piRNAs. MOV10L1 acts upstream of PIWI proteins in the piRNA pathway and is a master regulator of the piRNA biogenesis.
Title: Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity.
Mov10l1 mutant males are sterile owing to complete meiotic arrest. This mutant expresses Piwi proteins but lacks piRNAs, suggesting that MOV10L1 is required for piRNA biogenesis and/or loading to Piwi proteins.
Title: Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.
studies reveal a crucial role of MOV10L1 in male fertility and piRNA-directed retrotransposon silencing in male germ cells and suggest that MOV10L1 functions as a key component of a safeguard mechanism for the genetic information in male germ cells
Title: MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G65203 (e-PCR)
- UniSTS:225865

G65779 (e-PCR)
- UniSTS:225901

Mov10l1 (e-PCR), detects polymorphism
- UniSTS:265668

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables piRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in transposable element silencing by piRNA-mediated DNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in pi-body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA helicase Mov10l1

Names: MOV10-like protein 1 homolog; Moloney leukemia virus 10-like 1 protein; cardiac helicase activated by MEF2 protein; cardiac-specific RNA helicase; moloney leukemia virus 10-like protein 1 homolog; putative helicase Mov10l1

NP_112550.2

EC 3.6.4.13

XP_006521619.1

EC 3.6.4.13

XP_006521620.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031260.2 → NP_112550.2 RNA helicase Mov10l1

See identical proteins and their annotated locations for NP_112550.2

Status: VALIDATED

Source sequence(s)

AC119959, AF285587, AK084786, BG086707, DV656742

Consensus CDS

CCDS27737.1

UniProtKB/Swiss-Prot

Q7TPA9, Q8C3W0, Q924C2, Q99MV5

UniProtKB/TrEMBL

G3X8T0

Related

ENSMUSP00000015509.5, ENSMUST00000015509.11

Conserved Domains (4) summary

COG1112
Location:809 → 1173

DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]

pfam13086
Location:747 → 928

AAA_11; AAA domain

pfam13087
Location:935 → 1151

AAA_12; AAA domain

cl21455
Location:746 → 924

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

88867094..88939355

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521556.1 → XP_006521619.1 RNA helicase Mov10l1 isoform X1

See identical proteins and their annotated locations for XP_006521619.1

UniProtKB/TrEMBL

D3YWG8, F2YMC1

Conserved Domains (3) summary

cd18808
Location:1028 → 1218

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd18078
Location:798 → 1027

DEXXQc_Mov10L1; DEXXQ-box helicase domain of Mov10L1

pfam14444
Location:119 → 161

S1-like
XM_006521557.1 → XP_006521620.1 RNA helicase Mov10l1 isoform X2

UniProtKB/TrEMBL

F2YMC1

Conserved Domains (3) summary

cd18808
Location:1006 → 1196

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd18078
Location:776 → 1005

DEXXQc_Mov10L1; DEXXQ-box helicase domain of Mov10L1

pfam14444
Location:119 → 161

S1-like