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    Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20541, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc8a1provided by MGI
    Official Full Name
    solute carrier family 8 (sodium/calcium exchanger), member 1provided by MGI
    Primary source
    MGI:MGI:107956
    See related
    Ensembl:ENSMUSG00000054640 AllianceGenome:MGI:107956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ncx1; D930008O12Rik
    Summary
    Enables ankyrin binding activity; calcium:sodium antiporter activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to caffeine; metal ion transport; and vascular associated smooth muscle contraction. Acts upstream of or within several processes, including embryonic organ development; metal ion transport; and negative regulation of protein serine/threonine kinase activity. Located in several cellular components, including T-tubule; basolateral plasma membrane; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and nose. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 10.8), frontal lobe adult (RPKM 7.0) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc8a1 in Genome Data Viewer
    Location:
    17 E3; 17 51.29 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (81680534..82045816, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (81373105..81738387, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33944 Neighboring gene STARR-seq mESC enhancer starr_43340 Neighboring gene STARR-seq mESC enhancer starr_43341 Neighboring gene predicted gene, 53964 Neighboring gene STARR-seq mESC enhancer starr_43343 Neighboring gene STARR-seq mESC enhancer starr_43344 Neighboring gene STARR-seq mESC enhancer starr_43345 Neighboring gene STARR-seq mESC enhancer starr_43346 Neighboring gene STARR-seq mESC enhancer starr_43347 Neighboring gene ribosomal protein L31. pseudogene 25 Neighboring gene SET translocation pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC90693

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ankyrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ankyrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium:sodium antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calcium:sodium antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium:sodium antiporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion export IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion export ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in calcium ion transport into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell communication by electrical coupling involved in cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to caffeine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within muscle cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle cell membrane potential TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of the force of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in relaxation of smooth muscle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ATP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to muscle stretch ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vascular associated smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium/calcium exchanger 1
    Names
    Na(+)/Ca(2+)-exchange protein 1
    Na/Ca exchanger
    solute carrier family 8 member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112798.2NP_001106269.1  sodium/calcium exchanger 1 isoform B precursor

      See identical proteins and their annotated locations for NP_001106269.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) lacks two in-frame exons in the coding region, compared to variant A. The resulting isoform (B) lacks two internal segments, compared to isoform A.
      Source sequence(s)
      AC122399, BB660129, BC079673
      Consensus CDS
      CCDS50191.1
      UniProtKB/TrEMBL
      G5E8Y0, Q68FL0
      Related
      ENSMUSP00000157278.2, ENSMUST00000234131.2
      Conserved Domains (1) summary
      TIGR00845
      Location:1958
      caca; sodium/calcium exchanger 1
    2. NM_001286684.1NP_001273613.1  sodium/calcium exchanger 1 isoform C precursor

      See identical proteins and their annotated locations for NP_001273613.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C) lacks an internal segment in the 3' terminal exon, which results in an alternate stop codon, compared to variant A. The resulting isoform (C) has a shorter and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC104139, AC122399, AC131656
      Consensus CDS
      CCDS89163.1
      UniProtKB/TrEMBL
      A0A3Q4EBU5, O35157
      Related
      ENSMUSP00000157030.2, ENSMUST00000235015.2
      Conserved Domains (5) summary
      smart00237
      Location:534624
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:1935
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:797928
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:403493
      Calx-beta; Calx-beta domain
      pfam16494
      Location:251381
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
    3. NM_011406.3NP_035536.2  sodium/calcium exchanger 1 isoform A precursor

      See identical proteins and their annotated locations for NP_035536.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) encodes the longest isoform (A).
      Source sequence(s)
      AC122399, BB660129, BC079673, U70033
      Consensus CDS
      CCDS37706.1
      UniProtKB/Swiss-Prot
      P70414
      UniProtKB/TrEMBL
      G3X9J1
      Related
      ENSMUSP00000132809.3, ENSMUST00000163123.3
      Conserved Domains (1) summary
      TIGR00845
      Location:1970
      caca; sodium/calcium exchanger 1

    RNA

    1. NR_104580.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (D) differs in several internal exons, compared to variant A. This variant is represented as non-coding because the use of the 5'-most expected translation start codon, as used in variant A, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC104139, AC122399, AC131656

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      81680534..82045816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523933.3XP_006523996.1  sodium/calcium exchanger 1 isoform X1

      See identical proteins and their annotated locations for XP_006523996.1

      UniProtKB/Swiss-Prot
      P70414
      UniProtKB/TrEMBL
      G3X9J1
      Conserved Domains (1) summary
      TIGR00845
      Location:1970
      caca; sodium/calcium exchanger 1
    2. XM_006523944.2XP_006524007.1  sodium/calcium exchanger 1 isoform X12

      UniProtKB/TrEMBL
      G5E8Y0
      Conserved Domains (1) summary
      TIGR00845
      Location:1934
      caca; sodium/calcium exchanger 1
    3. XM_006523940.2XP_006524003.1  sodium/calcium exchanger 1 isoform X8

      UniProtKB/TrEMBL
      G5E8Y0
      Conserved Domains (1) summary
      TIGR00845
      Location:1957
      caca; sodium/calcium exchanger 1
    4. XM_006523938.2XP_006524001.1  sodium/calcium exchanger 1 isoform X6

      UniProtKB/TrEMBL
      G5E8Y0
      Conserved Domains (1) summary
      TIGR00845
      Location:1962
      caca; sodium/calcium exchanger 1
    5. XM_006523942.2XP_006524005.1  sodium/calcium exchanger 1 isoform X10

      UniProtKB/Swiss-Prot
      P70414
      Conserved Domains (1) summary
      TIGR00845
      Location:1941
      caca; sodium/calcium exchanger 1
    6. XM_006523936.2XP_006523999.1  sodium/calcium exchanger 1 isoform X4

      UniProtKB/Swiss-Prot
      P70414
      Conserved Domains (1) summary
      TIGR00845
      Location:1964
      caca; sodium/calcium exchanger 1
    7. XM_006523934.2XP_006523997.1  sodium/calcium exchanger 1 isoform X2

      UniProtKB/Swiss-Prot
      P70414
      Conserved Domains (1) summary
      TIGR00845
      Location:1969
      caca; sodium/calcium exchanger 1
    8. XM_006523943.2XP_006524006.1  sodium/calcium exchanger 1 isoform X11

      UniProtKB/TrEMBL
      G5E8Y0
      Conserved Domains (1) summary
      TIGR00845
      Location:1935
      caca; sodium/calcium exchanger 1
    9. XM_006523939.2XP_006524002.1  sodium/calcium exchanger 1 isoform X7

      See identical proteins and their annotated locations for XP_006524002.1

      UniProtKB/TrEMBL
      G5E8Y0, Q68FL0
      Conserved Domains (1) summary
      TIGR00845
      Location:1958
      caca; sodium/calcium exchanger 1
    10. XM_006523937.2XP_006524000.1  sodium/calcium exchanger 1 isoform X5

      UniProtKB/TrEMBL
      G5E8Y0
      Related
      ENSMUSP00000126373.3, ENSMUST00000163680.9
      Conserved Domains (1) summary
      TIGR00845
      Location:1963
      caca; sodium/calcium exchanger 1
    11. XM_006523941.2XP_006524004.1  sodium/calcium exchanger 1 isoform X9

      UniProtKB/Swiss-Prot
      P70414
      Conserved Domains (1) summary
      TIGR00845
      Location:1942
      caca; sodium/calcium exchanger 1
    12. XM_006523935.2XP_006523998.1  sodium/calcium exchanger 1 isoform X3

      UniProtKB/Swiss-Prot
      P70414
      Conserved Domains (1) summary
      TIGR00845
      Location:1965
      caca; sodium/calcium exchanger 1
    13. XM_006523932.2XP_006523995.1  sodium/calcium exchanger 1 isoform X1

      See identical proteins and their annotated locations for XP_006523995.1

      UniProtKB/Swiss-Prot
      P70414
      UniProtKB/TrEMBL
      G3X9J1
      Conserved Domains (1) summary
      TIGR00845
      Location:1970
      caca; sodium/calcium exchanger 1
    14. XM_017317368.2XP_017172857.1  sodium/calcium exchanger 1 isoform X13

      UniProtKB/TrEMBL
      Q27PY9, Q91ZJ7
      Conserved Domains (1) summary
      TIGR00845
      Location:1639
      caca; sodium/calcium exchanger 1
    15. XM_017317369.2XP_017172858.1  sodium/calcium exchanger 1 isoform X13

      UniProtKB/TrEMBL
      Q27PY9, Q91ZJ7
      Related
      ENSMUSP00000159714.1, ENSMUST00000249357.1
      Conserved Domains (1) summary
      TIGR00845
      Location:1639
      caca; sodium/calcium exchanger 1
    16. XM_017317370.2XP_017172859.1  sodium/calcium exchanger 1 isoform X13

      UniProtKB/TrEMBL
      Q27PY9, Q91ZJ7
      Conserved Domains (1) summary
      TIGR00845
      Location:1639
      caca; sodium/calcium exchanger 1

    RNA

    1. XR_004939482.1 RNA Sequence