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    Srp14 signal recognition particle 14 [ Mus musculus (house mouse) ]

    Gene ID: 20813, updated on 9-Dec-2024

    Summary

    Official Symbol
    Srp14provided by MGI
    Official Full Name
    signal recognition particle 14provided by MGI
    Primary source
    MGI:MGI:107169
    See related
    Ensembl:ENSMUSG00000009549 AllianceGenome:MGI:107169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    14kDa
    Summary
    Predicted to enable 7S RNA binding activity and endoplasmic reticulum signal peptide binding activity. Predicted to be involved in protein targeting to ER. Predicted to be located in nucleus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in 4-cell stage embryo; cerebral cortex; ganglia; and thymus primordium. Orthologous to human SRP14 (signal recognition particle 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 71.5), CNS E14 (RPKM 67.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Srp14 in Genome Data Viewer
    Location:
    2 E5; 2 59.4 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118306324..118310177, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118475843..118479696, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 176 Neighboring gene RIKEN cDNA 1700054M17 gene Neighboring gene STARR-seq mESC enhancer starr_05459 Neighboring gene STARR-positive B cell enhancer ABC_E1594 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4 Neighboring gene STARR-positive B cell enhancer ABC_E9525 Neighboring gene STARR-seq mESC enhancer starr_05460 Neighboring gene STARR-positive B cell enhancer ABC_E10132 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:118325145-118325353 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:118325384-118325664 Neighboring gene aldo-keto reductase family 1, member B3 pseudogene Neighboring gene predicted gene, 32684

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables endoplasmic reticulum signal peptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein targeting to ER ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of signal recognition particle, endoplasmic reticulum targeting IEA
    Inferred from Electronic Annotation
    more info
     
    part_of signal recognition particle, endoplasmic reticulum targeting ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    signal recognition particle 14 kDa protein
    Names
    (homologous Alu RNA binding protein)
    homologous Alu RNA-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009273.4NP_033299.1  signal recognition particle 14 kDa protein

      See identical proteins and their annotated locations for NP_033299.1

      Status: VALIDATED

      Source sequence(s)
      AK019310, AV338114, BB848168, CD774307
      Consensus CDS
      CCDS16577.1
      UniProtKB/Swiss-Prot
      P16254, Q3TIK2
      Related
      ENSMUSP00000009693.9, ENSMUST00000009693.15
      Conserved Domains (1) summary
      pfam02290
      Location:494
      SRP14; Signal recognition particle 14kD protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      118306324..118310177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)