U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ninl ninein-like [ Mus musculus (house mouse) ]

    Gene ID: 78177, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ninlprovided by MGI
    Official Full Name
    ninein-likeprovided by MGI
    Primary source
    MGI:MGI:1925427
    See related
    Ensembl:ENSMUSG00000068115 AllianceGenome:MGI:1925427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1004; Gm1634; mKIAA0980; 4930519N13Rik
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in microtubule anchoring at centrosome. Predicted to be located in cytoplasm and microtubule. Predicted to be active in centrosome. Is expressed in liver left lobe and liver right lobe. Orthologous to human NINL (ninein like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 7.2), CNS E11.5 (RPKM 6.5) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ninl in Genome Data Viewer
    Location:
    2 G3; 2 74.76 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150776439..150851330, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150934519..151009411, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene GINS complex subunit 1 Neighboring gene ribosomal protein L41 pseudogene Neighboring gene eukaryotic translation initiation factor 4E-binding protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06020 Neighboring gene STARR-seq mESC enhancer starr_06023 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3410 Neighboring gene N-acetylneuraminic acid phosphatase Neighboring gene STARR-seq mESC enhancer starr_06026 Neighboring gene predicted gene, 22187

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in microtubule anchoring at centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207204.2NP_997087.2  ninein-like protein

      See identical proteins and their annotated locations for NP_997087.2

      Status: VALIDATED

      Source sequence(s)
      BC067071, BU058995, BY302641, BY715392, CO427181
      Consensus CDS
      CCDS50744.1
      UniProtKB/Swiss-Prot
      A2ANB8, Q6NXH6, Q6ZQ12
      Related
      ENSMUSP00000105522.2, ENSMUST00000109896.8
      Conserved Domains (3) summary
      cd00051
      Location:213260
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam10221
      Location:622707
      DUF2151; Cell cycle and development regulator
      pfam13499
      Location:202260
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      150776439..150851330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500406.4XP_006500469.1  ninein-like protein isoform X1

      Conserved Domains (4) summary
      PRK13589
      Location:305363
      PRK13589; flagellin A
      COG1196
      Location:6221392
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:10851395
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:205266
      EF-hand_7; EF-hand domain pair
    2. XM_030252241.1XP_030108101.1  ninein-like protein isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:85448
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:7651075
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    3. XM_030252240.1XP_030108100.1  ninein-like protein isoform X6

      Conserved Domains (4) summary
      PRK13589
      Location:248306
      PRK13589; flagellin A
      COG1196
      Location:3381336
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:10281338
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:1171
      EF-hand_7; EF-hand domain pair
    4. XM_030252239.2XP_030108099.1  ninein-like protein isoform X4

      Conserved Domains (3) summary
      COG1196
      Location:5841354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:10471357
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:199260
      EF-hand_7; EF-hand domain pair
    5. XM_030252242.2XP_030108102.1  ninein-like protein isoform X8

      Conserved Domains (2) summary
      COG1196
      Location:38401
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:7181028
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    6. XM_030252243.2XP_030108103.1  ninein-like protein isoform X9

      Conserved Domains (2) summary
      COG1196
      Location:12343
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:660970
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    7. XM_006500407.4XP_006500470.1  ninein-like protein isoform X2

      Conserved Domains (3) summary
      COG1196
      Location:5901360
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:10531363
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:205266
      EF-hand_7; EF-hand domain pair
    8. XM_006500409.4XP_006500472.1  ninein-like protein isoform X5

      Conserved Domains (4) summary
      PRK13589
      Location:254312
      PRK13589; flagellin A
      COG1196
      Location:5711341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:10341344
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:1777
      EF-hand_7; EF-hand domain pair
    9. XM_006500408.4XP_006500471.1  ninein-like protein isoform X3

      Conserved Domains (3) summary
      PRK13589
      Location:305363
      PRK13589; flagellin A
      TIGR02168
      Location:4371358
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:205266
      EF-hand_7; EF-hand domain pair
    10. XM_011239847.3XP_011238149.1  ninein-like protein isoform X10

      See identical proteins and their annotated locations for XP_011238149.1

      Conserved Domains (1) summary
      TIGR02168
      Location:460770
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type