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    Samd9l sterile alpha motif domain containing 9-like [ Mus musculus (house mouse) ]

    Gene ID: 209086, updated on 9-Dec-2024

    Summary

    Official Symbol
    Samd9lprovided by MGI
    Official Full Name
    sterile alpha motif domain containing 9-likeprovided by MGI
    Primary source
    MGI:MGI:1343184
    See related
    Ensembl:ENSMUSG00000047735 AllianceGenome:MGI:1343184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM25; mKIAA2005
    Summary
    Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; endosomal vesicle fusion; and spleen development. Located in early endosome. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in autosomal dominant cerebellar ataxia. Orthologous to human SAMD9L (sterile alpha motif domain containing 9 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 4.1), bladder adult (RPKM 3.7) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Samd9l in Genome Data Viewer
    Location:
    6 A1; 6 1.76 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (3372257..3399458, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (3372257..3399571, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 384 pseudogene Neighboring gene STARR-seq mESC enhancer starr_14986 Neighboring gene STARR-positive B cell enhancer ABC_E9269 Neighboring gene predicted gene, 20559 Neighboring gene STARR-seq mESC enhancer starr_14987 Neighboring gene STARR-seq mESC enhancer starr_14988 Neighboring gene STARR-seq mESC enhancer starr_14989 Neighboring gene STARR-positive B cell enhancer mm9_chr6:3349393-3349694 Neighboring gene STARR-seq mESC enhancer starr_14990 Neighboring gene STARR-seq mESC enhancer starr_14991 Neighboring gene STARR-positive B cell enhancer ABC_E6412 Neighboring gene HEPACAM family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E9270 Neighboring gene VPS50 EARP/GARPII complex subunit Neighboring gene STARR-seq mESC enhancer starr_14997 Neighboring gene predicted gene, 52885

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    sterile alpha motif domain-containing protein 9-like
    Names
    SAM domain-containing protein 9-like
    v-myc myelocytomatosis viral related oncogene, neuroblastoma derived

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010156.4NP_034286.2  sterile alpha motif domain-containing protein 9-like

      See identical proteins and their annotated locations for NP_034286.2

      Status: VALIDATED

      Source sequence(s)
      AC022453
      Consensus CDS
      CCDS51712.1
      UniProtKB/Swiss-Prot
      Q69Z37
      UniProtKB/TrEMBL
      E9PX59
      Related
      ENSMUSP00000112688.2, ENSMUST00000120087.6
      Conserved Domains (1) summary
      cd09528
      Location:1276
      SAM_Samd9_Samd9L; SAM domain of Samd9/Samd9L subfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      3372257..3399458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505026.3XP_006505089.1  sterile alpha motif domain-containing protein 9-like isoform X1

      See identical proteins and their annotated locations for XP_006505089.1

      UniProtKB/Swiss-Prot
      Q69Z37
      UniProtKB/TrEMBL
      E9PX59
      Conserved Domains (1) summary
      cd09528
      Location:1276
      SAM_Samd9_Samd9L; SAM domain of Samd9/Samd9L subfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177590.1: Suppressed sequence

      Description
      NM_177590.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.