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    Tafa4 TAFA chemokine like family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 320701, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tafa4provided by MGI
    Official Full Name
    TAFA chemokine like family member 4provided by MGI
    Primary source
    MGI:MGI:2444563
    See related
    Ensembl:ENSMUSG00000046500 AllianceGenome:MGI:2444563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tafa-4; Fam19a4; C130034I18Rik; Fam19a4 Tafa-4
    Summary
    Enables receptor ligand activity. Involved in several processes, including macrophage chemotaxis; phagocytosis; and superoxide anion generation. Acts upstream of or within regulation of membrane potential and regulation of sensory perception of pain. Located in extracellular space. Is active in glutamatergic synapse and synaptic vesicle membrane. Is expressed in central nervous system; dorsal root ganglion; inner ear; and tooth. Orthologous to human TAFA4 (TAFA chemokine like family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tafa4 in Genome Data Viewer
    Location:
    6 D3; 6 44.8 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (96808167..97037452, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (96831206..97060411, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 1 Neighboring gene predicted gene, 22971 Neighboring gene STARR-seq mESC enhancer starr_16762 Neighboring gene predicted gene, 26011 Neighboring gene STARR-seq mESC enhancer starr_16763 Neighboring gene STARR-seq mESC enhancer starr_16764 Neighboring gene STARR-seq mESC enhancer starr_16765 Neighboring gene STARR-seq mESC enhancer starr_16766 Neighboring gene STARR-seq mESC enhancer starr_16767 Neighboring gene STARR-seq mESC enhancer starr_16770 Neighboring gene STARR-seq mESC enhancer starr_16771 Neighboring gene STARR-seq mESC enhancer starr_16773 Neighboring gene STARR-seq mESC enhancer starr_16775 Neighboring gene STARR-seq mESC enhancer starr_16776 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene predicted gene, 26175 Neighboring gene TATA element modulatory factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC107151

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in macrophage chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    chemokine-like protein TAFA-4
    Names
    family with sequence similarity 19 (chemokine (C-C motif)-like), member A4
    family with sequence similarity 19, member A4
    protein FAM19A4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177233.5NP_796207.2  chemokine-like protein TAFA-4 precursor

      See identical proteins and their annotated locations for NP_796207.2

      Status: VALIDATED

      Source sequence(s)
      AC133086, AC160399
      Consensus CDS
      CCDS51858.1
      UniProtKB/Swiss-Prot
      Q5FWC0, Q7TPG5, Q8BV02
      Related
      ENSMUSP00000086710.5, ENSMUST00000089295.6
      Conserved Domains (1) summary
      pfam12020
      Location:46133
      TAFA; TAFA family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      96808167..97037452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166237.1XP_036022130.1  chemokine-like protein TAFA-4 isoform X2

      UniProtKB/Swiss-Prot
      Q5FWC0, Q7TPG5, Q8BV02
      Conserved Domains (1) summary
      pfam12020
      Location:46133
      TAFA; TAFA family
    2. XM_036166236.1XP_036022129.1  chemokine-like protein TAFA-4 isoform X2

      UniProtKB/Swiss-Prot
      Q5FWC0, Q7TPG5, Q8BV02
      Conserved Domains (1) summary
      pfam12020
      Location:46133
      TAFA; TAFA family
    3. XM_017321648.3XP_017177137.1  chemokine-like protein TAFA-4 isoform X2

      UniProtKB/Swiss-Prot
      Q5FWC0, Q7TPG5, Q8BV02
      Conserved Domains (1) summary
      pfam12020
      Location:46133
      TAFA; TAFA family
    4. XM_030255465.1XP_030111325.1  chemokine-like protein TAFA-4 isoform X1

      Conserved Domains (1) summary
      pfam12020
      Location:77164
      TAFA; TAFA family