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    Carmil2 capping protein regulator and myosin 1 linker 2 [ Mus musculus (house mouse) ]

    Gene ID: 234695, updated on 9-Dec-2024

    Summary

    Official Symbol
    Carmil2provided by MGI
    Official Full Name
    capping protein regulator and myosin 1 linker 2provided by MGI
    Primary source
    MGI:MGI:2685431
    See related
    Ensembl:ENSMUSG00000050357 AllianceGenome:MGI:2685431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm585; Rltpr; CG1399-PB; D130029J02Rik
    Summary
    Predicted to enable phospholipid binding activity. Acts upstream of or within several processes, including T cell receptor signaling pathway; positive regulation of T cell activation; and positive regulation of cytokine production. Located in cell-cell junction; cytoplasm; and immunological synapse. Part of F-actin capping protein complex. Human ortholog(s) of this gene implicated in immunodeficiency 58. Orthologous to human CARMIL2 (capping protein regulator and myosin 1 linker 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 117.5), spleen adult (RPKM 27.1) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Carmil2 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106412642..106424827)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105686010..105698195)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5914 Neighboring gene CCCTC-binding factor Neighboring gene myosin light polypeptide 6-like Neighboring gene STARR-positive B cell enhancer ABC_E5037 Neighboring gene predicted gene, 33578 Neighboring gene STARR-positive B cell enhancer ABC_E3798 Neighboring gene RIKEN cDNA 4933405L10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6678 Neighboring gene par-6 family cell polarity regulator alpha Neighboring gene adrenocortical dysplasia Neighboring gene enkurin domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament network formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament network formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment or maintenance of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment or maintenance of monopolar cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment or maintenance of monopolar cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of barbed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of barbed-end actin filament capping ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extracellular matrix disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of lamellipodium organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ruffle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wound healing, spreading of cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing, spreading of cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of F-actin capping protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in macropinosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in macropinosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    capping protein, Arp2/3 and myosin-I linker protein 2
    Names
    F-actin-uncapping protein RLTPR
    RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
    RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein
    leucine-rich repeat-containing protein 16C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357333.1NP_001344262.1  capping protein, Arp2/3 and myosin-I linker protein 2

      Status: VALIDATED

      Source sequence(s)
      BE988965, HF678090
      Consensus CDS
      CCDS90452.1
      UniProtKB/Swiss-Prot
      Q3V3V9
      UniProtKB/TrEMBL
      S0DHL8
      Related
      ENSMUSP00000148422.2, ENSMUST00000213019.2
      Conserved Domains (4) summary
      sd00033
      Location:459484
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:221245
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7811071
      CARMIL_C; CARMIL C-terminus
      cl26161
      Location:278643
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106412642..106424827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312742.2XP_017168231.1  capping protein, Arp2/3 and myosin-I linker protein 2 isoform X7

      UniProtKB/Swiss-Prot
      Q3V3V9
      Conserved Domains (5) summary
      sd00033
      Location:461486
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:223247
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7831072
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:41119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:280645
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. XM_017312741.3XP_017168230.1  capping protein, Arp2/3 and myosin-I linker protein 2 isoform X4

      UniProtKB/Swiss-Prot
      Q3V3V9
      Conserved Domains (5) summary
      sd00033
      Location:461486
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:223247
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7831072
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:41119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:280645
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. XM_017312740.2XP_017168229.1  capping protein, Arp2/3 and myosin-I linker protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q3V3V9
      Conserved Domains (5) summary
      sd00033
      Location:450475
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:212236
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7721061
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:41116
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:269634
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. XM_017312739.2XP_017168228.1  capping protein, Arp2/3 and myosin-I linker protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3V3V9
      Conserved Domains (5) summary
      sd00033
      Location:461486
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:223247
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7831072
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:41119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:280645
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    5. XM_011248358.3XP_011246660.1  capping protein, Arp2/3 and myosin-I linker protein 2 isoform X5

      UniProtKB/Swiss-Prot
      Q3V3V9
      Conserved Domains (5) summary
      sd00033
      Location:461486
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:223247
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7831072
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:41119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:280645
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    6. XM_006530898.4XP_006530961.1  capping protein, Arp2/3 and myosin-I linker protein 2 isoform X6

      UniProtKB/Swiss-Prot
      Q3V3V9
      Conserved Domains (5) summary
      sd00033
      Location:459484
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:221245
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7811070
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:41119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:278643
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    7. XM_006530899.5XP_006530962.1  capping protein, Arp2/3 and myosin-I linker protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3V3V9
      Conserved Domains (5) summary
      sd00033
      Location:459484
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:221245
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:7811070
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:41119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:278643
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033320.2: Suppressed sequence

      Description
      NM_001033320.2: This RefSeq was removed because currently there is insufficient support for the transcript and protein.