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    Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 [ Mus musculus (house mouse) ]

    Gene ID: 54405, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndufa1provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A1provided by MGI
    Primary source
    MGI:MGI:1929511
    See related
    Ensembl:ENSMUSG00000016427 AllianceGenome:MGI:1929511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MWFE; 1810049F12Rik
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; cranium; respiratory system; and sensory organ. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 12. Orthologous to human NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 199.1), kidney adult (RPKM 150.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ndufa1 in Genome Data Viewer
    Location:
    X A3.3; X 21.61 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36451241..36454891, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (37187588..37191238, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene UPF3 regulator of nonsense transcripts homolog B (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E5721 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:34666661-34666844 Neighboring gene NFKB activating protein Neighboring gene A kinase anchor protein 14 Neighboring gene predicted gene, 39503 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:34731294-34731403 Neighboring gene ring finger protein 113A1 Neighboring gene predicted gene 9 Neighboring gene reproductive homeobox 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
    Names
    CI-MWFE
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE)
    NADH dehydrogenase 1 alpha subcomplex, 1
    NADH ubiquinone oxidoreductase subunit MWFE
    NADH-ubiquinone oxidoreductase MWFE subunit
    complex I-MWFE
    NP_062316.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019443.2NP_062316.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

      See identical proteins and their annotated locations for NP_062316.1

      Status: VALIDATED

      Source sequence(s)
      AI844651, AK007840, CF383819
      Consensus CDS
      CCDS40928.1
      UniProtKB/Swiss-Prot
      O35683
      UniProtKB/TrEMBL
      Q545K0
      Related
      ENSMUSP00000016571.8, ENSMUST00000016571.8
      Conserved Domains (1) summary
      pfam15879
      Location:256
      MWFE; NADH-ubiquinone oxidoreductase MWFE subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      36451241..36454891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)