U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Pias4 protein inhibitor of activated STAT 4 [ Mus musculus (house mouse) ]

    Gene ID: 59004, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pias4provided by MGI
    Official Full Name
    protein inhibitor of activated STAT 4provided by MGI
    Primary source
    MGI:MGI:2136940
    See related
    Ensembl:ENSMUSG00000004934 AllianceGenome:MGI:2136940
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIASY; Piasg; Pias-gamma
    Summary
    Enables several functions, including SUMO ligase activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Involved in positive regulation of keratinocyte apoptotic process; protein sumoylation; and regulation of DNA-templated transcription. Acts upstream of or within central nervous system development; regulation of signal transduction; and skin epidermis development. Located in nuclear matrix and nucleoplasm. Part of transferase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hair follicle; and heart. Orthologous to human PIAS4 (protein inhibitor of activated STAT 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 63.4), colon adult (RPKM 20.2) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pias4 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80989795..81003554, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81153961..81167720, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E463 Neighboring gene STARR-positive B cell enhancer ABC_E8349 Neighboring gene STARR-seq mESC enhancer starr_27318 Neighboring gene zinc finger and BTB domain containing 7a Neighboring gene STARR-positive B cell enhancer ABC_E901 Neighboring gene STARR-positive B cell enhancer ABC_E8866 Neighboring gene STARR-positive B cell enhancer ABC_E3901 Neighboring gene STARR-positive B cell enhancer ABC_E5157 Neighboring gene STARR-positive B cell enhancer ABC_E2329 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene death-associated protein kinase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables SUMO ligase activity  
    enables SUMO ligase activity PubMed 
    enables SUMO ligase activity  
    enables SUMO transferase activity PubMed 
    enables SUMO transferase activity  
    enables SUMO transferase activity  
    enables protein binding PubMed 
    enables transcription coregulator activity  
    enables transcription corepressor activity PubMed 
    enables transcription corepressor activity PubMed 
    enables ubiquitin protein ligase binding PubMed 
    enables ubiquitin protein ligase binding  
    enables zinc ion binding  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway  
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT PubMed 
    acts_upstream_of_or_within central nervous system development PubMed 
    acts_upstream_of_or_within hair follicle development PubMed 
    acts_upstream_of_or_within limb epidermis development PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of NF-kappaB transcription factor activity PubMed 
    involved_in negative regulation of protein localization to chromatin  
    involved_in negative regulation of protein localization to chromatin  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within negative regulation of tumor necrosis factor-mediated signaling pathway PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination  
    involved_in positive regulation of double-strand break repair via homologous recombination  
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage PubMed 
    involved_in positive regulation of keratinocyte apoptotic process PubMed 
    involved_in positive regulation of protein sumoylation  
    involved_in positive regulation of protein sumoylation  
    involved_in protein sumoylation  
    acts_upstream_of_or_within protein sumoylation PubMed 
    involved_in protein sumoylation PubMed 
    involved_in protein sumoylation  
    involved_in protein sumoylation  
    involved_in regulation of mRNA stability  
    involved_in regulation of mRNA stability  
    involved_in regulation of transcription by RNA polymerase II  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in PML body  
    located_in chromatin  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in nuclear matrix PubMed 
    located_in nucleoplasm PubMed 
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of transferase complex PubMed 

    General protein information

    Preferred Names
    E3 SUMO-protein ligase PIAS4
    Names
    RING-type E3 ubiquitin transferase PIAS4
    protein inhibitor of activated STAT PIASy
    protein inhibitor of activated STAT protein 4
    protein inhibitor of activated STAT protein gamma
    NP_067476.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021501.4NP_067476.2  E3 SUMO-protein ligase PIAS4

      See identical proteins and their annotated locations for NP_067476.2

      Status: PROVISIONAL

      Source sequence(s)
      BC025159
      Consensus CDS
      CCDS35992.1
      UniProtKB/Swiss-Prot
      Q8R165, Q9JM05
      UniProtKB/TrEMBL
      Q3UGQ2, Q3ULQ6
      Related
      ENSMUSP00000005064.8, ENSMUST00000005064.14
      Conserved Domains (3) summary
      smart00513
      Location:1246
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:315364
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:124262
      PINIT; PINIT domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80989795..81003554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.