Slf1 SMC5-SMC6 complex localization factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slf1provided by MGI
Official Full Name: SMC5-SMC6 complex localization factor 1provided by MGI
Primary source: MGI:MGI:2145448
See related: Ensembl:ENSMUSG00000021597 AllianceGenome:MGI:2145448
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Brctx; Brctd1; Ankrd32; 2700017A04Rik; C730024G01Rik
Summary: Enables ubiquitin protein ligase binding activity. Involved in DNA damage response. Located in centrosome; cytoplasm; and nuclear inclusion body. Part of nucleosome. Is expressed in cerebral cortex marginal layer; cerebral cortex subventricular zone; cerebral cortex ventricular layer; cortical plate; and medulla oblongata basal plate mantle layer. Orthologous to human SLF1 (SMC5-SMC6 complex localization factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 4.5), CNS E18 (RPKM 4.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 40.98 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (77191207..77283632, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (77043088..77135513, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAD18 interacts with BRCTx in a phosphorylation-dependent manner
Title: RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage.
Results describe the cloning, characterization, and targeted mutagenesis of Brctx, a novel gene with a BRCT motif [Brctx].
Title: BRCTx is a novel, highly conserved RAD18-interacting protein.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237060

D13Mit231 (e-PCR), detects polymorphism
- UniSTS:127046

AW545819 (e-PCR)
- UniSTS:180562

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to site of double-strand break	ISO Inferred from Sequence Orthology more info
involved_in protein localization to site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inclusion body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: SMC5-SMC6 complex localization factor protein 1

Names: BRCT domain containing 1; BRCT domain-containing protein 1; ankyrin repeat domain 32; ankyrin repeat domain-containing protein 32; protein BRCTx

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134071.3 → NP_598832.3 SMC5-SMC6 complex localization factor protein 1

See identical proteins and their annotated locations for NP_598832.3

Status: VALIDATED

Source sequence(s)

AC122418, AC161266

Consensus CDS

CCDS26657.2

UniProtKB/Swiss-Prot

Q497V2, Q5XK30, Q8BHY5, Q8BQM6, Q8R3P9, Q921Y9

Related

ENSMUSP00000118312.3, ENSMUST00000151524.9

Conserved Domains (4) summary

sd00045
Location:803 → 834

ANK; ANK repeat [structural motif]

cd17750
Location:7 → 85

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:807 → 894

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:127 → 198

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

77191207..77283632 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244453.4 → XP_011242755.1 SMC5-SMC6 complex localization factor protein 1 isoform X2

See identical proteins and their annotated locations for XP_011242755.1

Conserved Domains (4) summary

sd00045
Location:812 → 843

ANK; ANK repeat [structural motif]

cd17750
Location:7 → 85

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:816 → 903

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:127 → 198

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_036157822.1 → XP_036013715.1 SMC5-SMC6 complex localization factor protein 1 isoform X9

Conserved Domains (4) summary

sd00045
Location:707 → 738

ANK; ANK repeat [structural motif]

cd17750
Location:7 → 85

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:711 → 798

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:127 → 198

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_036157820.1 → XP_036013713.1 SMC5-SMC6 complex localization factor protein 1 isoform X6

Conserved Domains (4) summary

sd00045
Location:755 → 786

ANK; ANK repeat [structural motif]

cd17750
Location:7 → 85

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:759 → 846

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:127 → 198

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_006517035.4 → XP_006517098.1 SMC5-SMC6 complex localization factor protein 1 isoform X3

Conserved Domains (4) summary

sd00045
Location:809 → 840

ANK; ANK repeat [structural motif]

cd17750
Location:13 → 91

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:813 → 900

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:133 → 204

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_011244456.4 → XP_011242758.1 SMC5-SMC6 complex localization factor protein 1 isoform X7

Conserved Domains (4) summary

sd00045
Location:713 → 744

ANK; ANK repeat [structural motif]

cd17750
Location:13 → 91

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:717 → 804

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:133 → 204

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_011244455.4 → XP_011242757.1 SMC5-SMC6 complex localization factor protein 1 isoform X5

Conserved Domains (4) summary

sd00045
Location:761 → 792

ANK; ANK repeat [structural motif]

cd17750
Location:13 → 91

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:765 → 852

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:133 → 204

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_011244452.4 → XP_011242754.1 SMC5-SMC6 complex localization factor protein 1 isoform X1

Conserved Domains (4) summary

sd00045
Location:818 → 849

ANK; ANK repeat [structural motif]

cd17750
Location:13 → 91

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:822 → 909

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:133 → 204

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_017315352.3 → XP_017170841.1 SMC5-SMC6 complex localization factor protein 1 isoform X8

Conserved Domains (3) summary

sd00045
Location:709 → 740

ANK; ANK repeat [structural motif]

pfam12796
Location:713 → 800

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:24 → 95

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_036157821.1 → XP_036013714.1 SMC5-SMC6 complex localization factor protein 1 isoform X6

Conserved Domains (4) summary

sd00045
Location:755 → 786

ANK; ANK repeat [structural motif]

cd17750
Location:7 → 85

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:759 → 846

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:127 → 198

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_017315351.3 → XP_017170840.1 SMC5-SMC6 complex localization factor protein 1 isoform X4

UniProtKB/Swiss-Prot

Q497V2, Q5XK30, Q8BHY5, Q8BQM6, Q8R3P9, Q921Y9

Conserved Domains (4) summary

sd00045
Location:803 → 834

ANK; ANK repeat [structural motif]

cd17750
Location:7 → 85

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:807 → 894

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:127 → 198

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_011244454.4 → XP_011242756.1 SMC5-SMC6 complex localization factor protein 1 isoform X2

See identical proteins and their annotated locations for XP_011242756.1

Conserved Domains (4) summary

sd00045
Location:812 → 843

ANK; ANK repeat [structural motif]

cd17750
Location:7 → 85

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:816 → 903

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:127 → 198

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_036157818.1 → XP_036013711.1 SMC5-SMC6 complex localization factor protein 1 isoform X2

Conserved Domains (4) summary

sd00045
Location:812 → 843

ANK; ANK repeat [structural motif]

cd17750
Location:7 → 85

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:816 → 903

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:127 → 198

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_036157819.1 → XP_036013712.1 SMC5-SMC6 complex localization factor protein 1 isoform X4

UniProtKB/Swiss-Prot

Q497V2, Q5XK30, Q8BHY5, Q8BQM6, Q8R3P9, Q921Y9

Conserved Domains (4) summary

sd00045
Location:803 → 834

ANK; ANK repeat [structural motif]

cd17750
Location:7 → 85

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:807 → 894

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:127 → 198

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_017315350.3 → XP_017170839.1 SMC5-SMC6 complex localization factor protein 1 isoform X2

Conserved Domains (4) summary

sd00045
Location:812 → 843

ANK; ANK repeat [structural motif]

cd17750
Location:7 → 85

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

pfam12796
Location:816 → 903

Ank_2; Ankyrin repeats (3 copies)

cl00038
Location:127 → 198

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
XM_017315353.1 → XP_017170842.1 SMC5-SMC6 complex localization factor protein 1 isoform X11

Conserved Domains (2) summary

sd00045
Location:322 → 353

ANK; ANK repeat [structural motif]

pfam12796
Location:326 → 413

Ank_2; Ankyrin repeats (3 copies)
XM_011244457.4 → XP_011242759.1 SMC5-SMC6 complex localization factor protein 1 isoform X10

Conserved Domains (2) summary

cd17750
Location:13 → 91

BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins

cl00038
Location:133 → 204

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains