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    Vamp5 vesicle-associated membrane protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 53620, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Vamp5provided by MGI
    Official Full Name
    vesicle-associated membrane protein 5provided by MGI
    Primary source
    MGI:MGI:1858622
    See related
    Ensembl:ENSMUSG00000073002 AllianceGenome:MGI:1858622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Camp
    Summary
    Acts upstream of or within Golgi to plasma membrane protein transport and skeletal muscle tissue development. Located in several cellular components, including cytoplasmic vesicle; intercalated disc; and perinuclear region of cytoplasm. Orthologous to human VAMP5 (vesicle associated membrane protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 12.4), liver E14 (RPKM 12.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vamp5 in Genome Data Viewer
    Location:
    6 C1; 6 32.27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72345032..72357451, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72368049..72380468, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 0610030E20 gene Neighboring gene transmembrane protein 150A Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:72312603-72312712 Neighboring gene ring finger protein 181 Neighboring gene predicted gene, 52494 Neighboring gene vesicle-associated membrane protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E10385 Neighboring gene STARR-positive B cell enhancer ABC_E2789 Neighboring gene gamma-glutamyl carboxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. VAMP5 promotes Fcγ receptor-mediated phagocytosis and regulates phagosome maturation in macrophages. Sakurai C, et al. Mol Biol Cell, 2024 Mar 1. PMID 38265888, Free PMC Article
    2. Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung. Ikezawa M, et al. Dev Dyn, 2018 May. PMID 29330887
    3. The localization of VAMP5 in skeletal and cardiac muscle. Takahashi M, et al. Histochem Cell Biol, 2013 Apr. PMID 23180306
    4. A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane. Zeng Q, et al. Mol Biol Cell, 1998 Sep. PMID 9725904, Free PMC Article
    5. The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network. Zeng Q, et al. J Biol Chem, 2003 Jun 20. PMID 12682051

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VAMP5 promotes Fcgamma receptor-mediated phagocytosis and regulates phagosome maturation in macrophages.
      Title: VAMP5 promotes Fcγ receptor-mediated phagocytosis and regulates phagosome maturation in macrophages.
    2. Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung
      Title: Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung.
    3. study found that VAMP5 was expressed in the type IIa fibers of skeletal muscle and that in cardiomyocytes, VAMP5 expression was localized to the vicinity of intercalated discs
      Title: The localization of VAMP5 in skeletal and cardiac muscle.
    4. The cytoplasmic domain of this protein is responsible for its correct subcellular targeting.
      Title: The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal muscle tissue development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vesicle-associated membrane protein 5
    Names
    VAMP-5
    myobrevin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080742.2 → NP_001074211.1  vesicle-associated membrane protein 5

      See identical proteins and their annotated locations for NP_001074211.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC116115, AK009266
      Consensus CDS
      CCDS39513.1
      UniProtKB/Swiss-Prot
      Q9Z2P8
      UniProtKB/TrEMBL
      Q5M9K2, Q791P0
      Related
      ENSMUSP00000073852.4, ENSMUST00000074231.6
      Conserved Domains (2) summary
      cd15872
      Location:5 → 70
      R-SNARE_VAMP5; SNARE motif of VAMP5
      pfam00957
      Location:4 → 79
      Synaptobrevin; Synaptobrevin

    2. NM_016872.4 → NP_058568.1  vesicle-associated membrane protein 5

      See identical proteins and their annotated locations for NP_058568.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC116115, BC086925
      Consensus CDS
      CCDS39513.1
      UniProtKB/Swiss-Prot
      Q9Z2P8
      UniProtKB/TrEMBL
      Q5M9K2, Q791P0
      Related
      ENSMUSP00000098843.4, ENSMUST00000101285.10
      Conserved Domains (2) summary
      cd15872
      Location:5 → 70
      R-SNARE_VAMP5; SNARE motif of VAMP5
      pfam00957
      Location:4 → 79
      Synaptobrevin; Synaptobrevin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72345032..72357451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2P8.1 GenPept UniProtKB/Swiss-Prot:Q9Z2P8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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