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    Ipcef1 interaction protein for cytohesin exchange factors 1 [ Mus musculus (house mouse) ]

    Gene ID: 320495, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ipcef1provided by MGI
    Official Full Name
    interaction protein for cytohesin exchange factors 1provided by MGI
    Primary source
    MGI:MGI:2444159
    See related
    Ensembl:ENSMUSG00000064065 AllianceGenome:MGI:2444159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A130090K04Rik
    Summary
    Predicted to enable protein domain specific binding activity. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human IPCEF1 (interaction protein for cytohesin exchange factors 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 7.0), frontal lobe adult (RPKM 6.9) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ipcef1 in Genome Data Viewer
    Location:
    10 A1; 10 1.85 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (6835779..6973185, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (6885779..7054782, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25585 Neighboring gene STARR-seq mESC enhancer starr_25584 Neighboring gene predicted gene 3213 Neighboring gene STARR-seq mESC enhancer starr_25583 Neighboring gene STARR-seq mESC enhancer starr_25582 Neighboring gene STARR-seq mESC enhancer starr_25581 Neighboring gene tripartite motif-containing 59 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25580 Neighboring gene opioid receptor, mu 1 Neighboring gene STARR-seq mESC enhancer starr_25578 Neighboring gene STARR-positive B cell enhancer ABC_E9781 Neighboring gene STARR-positive B cell enhancer ABC_E11427 Neighboring gene STARR-seq mESC enhancer starr_25577 Neighboring gene STARR-seq mESC enhancer starr_25576 Neighboring gene Cnksr family member 3 Neighboring gene predicted gene, 53610

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration. Marks KE, et al. Cell Rep, 2021 Jun 29. PMID 34192530, Free PMC Article
    2. Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Ling KH, et al. Genome Biol, 2009. PMID 19799774, Free PMC Article
    3. Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. Wu Y, et al. PLoS Genet, 2016 Sep. PMID 27689697, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration.
      Title: Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interactor protein for cytohesin exchange factors 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033391.2 → NP_001028563.1  interactor protein for cytohesin exchange factors 1 isoform 4

      See identical proteins and their annotated locations for NP_001028563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter, 5' UTR, and 5' coding region, and uses an alternate 3' splice pattern, compared to variant 1. The resulting isoform (4) differs at the N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AK135851
      Consensus CDS
      CCDS56689.1
      UniProtKB/TrEMBL
      Q3UX69
      Related
      ENSMUSP00000128131.2, ENSMUST00000170680.8
      Conserved Domains (3) summary
      pfam00169
      Location:7 → 60
      PH; PH domain
      pfam15310
      Location:67 → 143
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
      cl17171
      Location:7 → 68
      PH-like; Pleckstrin homology-like domain

    2. NM_001170800.1 → NP_001164271.1  interactor protein for cytohesin exchange factors 1 isoform 1

      See identical proteins and their annotated locations for NP_001164271.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC155718, AC164171
      Consensus CDS
      CCDS56688.1
      UniProtKB/Swiss-Prot
      Q3TZY2, Q5DU31, Q8CAP9
      Related
      ENSMUSP00000101242.2, ENSMUST00000105617.8
      Conserved Domains (2) summary
      cd01260
      Location:2 → 115
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam11928
      Location:140 → 190
      DUF3446; Domain of unknown function (DUF3446)

    3. NM_001170801.1 → NP_001164272.1  interactor protein for cytohesin exchange factors 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site and an alternate 3' splice pattern, compared to variant 1. The resulting isoform (2) includes an additional 4-aa segment and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC155718, AC164171
      Related
      ENSMUST00000154998.8
      Conserved Domains (3) summary
      cd01260
      Location:2 → 115
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:16 → 107
      PH; PH domain
      pfam15310
      Location:114 → 194
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling

    4. NM_001170802.1 → NP_001164273.1  interactor protein for cytohesin exchange factors 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' splice pattern, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC155718, AC164171
      Related
      ENSMUST00000144622.8
      Conserved Domains (3) summary
      cd01260
      Location:2 → 115
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:16 → 107
      PH; PH domain
      pfam15310
      Location:114 → 190
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling

    5. NM_001347225.1 → NP_001334154.1  interactor protein for cytohesin exchange factors 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AA472059, AK038257, AK038911, AK135851, BQ176089, CK781068
      Consensus CDS
      CCDS83676.1
      UniProtKB/Swiss-Prot
      Q5DU31
      UniProtKB/TrEMBL
      Q3UX69
      Related
      ENSMUSP00000077215.4, ENSMUST00000078070.10
      Conserved Domains (1) summary
      cd01260
      Location:2 → 115
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      6835779..6973185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243081.1 → XP_011241383.1  interactor protein for cytohesin exchange factors 1 isoform X2

      Conserved Domains (1) summary
      cd01260
      Location:24 → 137
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain

    2. XM_011243082.3 → XP_011241384.1  interactor protein for cytohesin exchange factors 1 isoform X3

      Conserved Domains (1) summary
      cd01260
      Location:25 → 138
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain

    3. XM_011243080.3 → XP_011241382.1  interactor protein for cytohesin exchange factors 1 isoform X1

      Conserved Domains (1) summary
      cd01260
      Location:25 → 138
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain

    4. XM_030245126.2 → XP_030100986.1  interactor protein for cytohesin exchange factors 1 isoform X4

      Conserved Domains (1) summary
      cd01260
      Location:2 → 115
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DU31.2 GenPept UniProtKB/Swiss-Prot:Q5DU31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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