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    Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta [ Mus musculus (house mouse) ]

    Gene ID: 13667, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Eif2b4provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2B, subunit 4 deltaprovided by MGI
    Primary source
    MGI:MGI:95300
    See related
    Ensembl:ENSMUSG00000029145 AllianceGenome:MGI:95300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif2b
    Summary
    Predicted to enable translation initiation factor binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; nervous system development; and response to glucose. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in several structures, including adipose tissue; brain; eye; gut gland; and male reproductive gland or organ. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.0), thymus adult (RPKM 17.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif2b4 in Genome Data Viewer
    Location:
    5 B1; 5 17.24 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31344902..31350483, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31187558..31193139, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene MpV17 mitochondrial inner membrane protein Neighboring gene general transcription factor IIIC, polypeptide 2, beta Neighboring gene STARR-seq mESC enhancer starr_12767 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31495236-31495423 Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matter. Oudejans E, et al. Life Sci Alliance, 2024 Mar. PMID 38171595, Free PMC Article
    2. The delta-subunit of murine guanine nucleotide exchange factor eIF-2B. Characterization of cDNAs predicts isoforms differing at the amino-terminal end. Henderson RA, et al. J Biol Chem, 1994 Dec 2. PMID 7982969
    3. Astrocytes are central in the pathomechanisms of vanishing white matter. Dooves S, et al. J Clin Invest, 2016 Apr 1. PMID 26974157, Free PMC Article
    4. Vanishing white matter: deregulated integrated stress response as therapy target. Abbink TEM, et al. Ann Clin Transl Neurol, 2019 Aug. PMID 31402619, Free PMC Article
    5. Lithium: effects in animal models of vanishing white matter are not promising. Witkamp D, et al. Front Neurosci, 2024. PMID 38352041, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoplasmic translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligodendrocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ovarian follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation factor eIF2B subunit delta
    Names
    eIF-2B GDP-GTP exchange factor subunit delta
    eIF2B GDP-GTP exchange factor subunit delta
    translation initiation factor eIF-2B subunit delta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127355.1 → NP_001120827.1  translation initiation factor eIF2B subunit delta isoform 1

      See identical proteins and their annotated locations for NP_001120827.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AK158282, BB665023, BB857319, CD768292
      Consensus CDS
      CCDS51457.1
      UniProtKB/TrEMBL
      D3Z780
      Related
      ENSMUSP00000130880.2, ENSMUST00000166769.8
      Conserved Domains (2) summary
      COG1184
      Location:240 → 538
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:240 → 530
      IF-2B; Initiation factor 2 subunit family

    2. NM_001127356.1 → NP_001120828.1  translation initiation factor eIF2B subunit delta isoform 1

      See identical proteins and their annotated locations for NP_001120828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AK158282, BB665023, BU707309, CD768292
      Consensus CDS
      CCDS51457.1
      UniProtKB/TrEMBL
      D3Z780
      Related
      ENSMUSP00000110250.2, ENSMUST00000114603.8
      Conserved Domains (2) summary
      COG1184
      Location:240 → 538
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:240 → 530
      IF-2B; Initiation factor 2 subunit family

    3. NM_010122.2 → NP_034252.2  translation initiation factor eIF2B subunit delta isoform 2

      See identical proteins and their annotated locations for NP_034252.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment spanning the 5' UTR and 5' coding region, compared to variant 1, resulting in translation initiation from an alternate start codon and a shorter protein (isoform 2) with a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK158282, BB665023, CD768292
      Consensus CDS
      CCDS19176.1
      UniProtKB/Swiss-Prot
      Q3TYW7, Q61748, Q61749, Q8VC35
      UniProtKB/TrEMBL
      D3Z780
      Related
      ENSMUSP00000076875.4, ENSMUST00000077693.10
      Conserved Domains (2) summary
      COG1184
      Location:220 → 518
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:220 → 510
      IF-2B; Initiation factor 2 subunit family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31344902..31350483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61749.2 GenPept UniProtKB/Swiss-Prot:Q61749

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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