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    Pigz phosphatidylinositol glycan anchor biosynthesis, class Z [ Mus musculus (house mouse) ]

    Gene ID: 239827, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pigzprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Zprovided by MGI
    Primary source
    MGI:MGI:2443822
    See related
    Ensembl:ENSMUSG00000045625 AllianceGenome:MGI:2443822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F630022B06Rik
    Summary
    Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human PIGZ (phosphatidylinositol glycan anchor biosynthesis class Z). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 2.0), cortex adult (RPKM 1.4) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pigz in Genome Data Viewer
    Location:
    16 B2; 16 22.4 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31745797..31764866)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31926965..31946048)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34476 Neighboring gene ribonuclease H2, large subunit pseudogene Neighboring gene Ncbp2 antisense 2 (head to head) Neighboring gene nuclear cap binding protein subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alpha-1,2-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    GPI mannosyltransferase 4
    Names
    GPI mannosyltransferase IV
    GPI-MT-IV
    PIG-Z
    phosphatidylinositol glycan, class Z
    phosphatidylinositol-glycan biosynthesis class Z protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172822.3NP_766410.2  GPI mannosyltransferase 4

      See identical proteins and their annotated locations for NP_766410.2

      Status: VALIDATED

      Source sequence(s)
      AC124681
      Consensus CDS
      CCDS28109.1
      UniProtKB/Swiss-Prot
      Q149K0, Q8BTP0
      Related
      ENSMUSP00000057509.3, ENSMUST00000052174.3
      Conserved Domains (1) summary
      cl21590
      Location:15406
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      31745797..31764866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522119.5XP_006522182.1  GPI mannosyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_006522182.1

      UniProtKB/Swiss-Prot
      Q149K0, Q8BTP0
      Conserved Domains (1) summary
      cl21590
      Location:15406
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    2. XM_006522120.5XP_006522183.1  GPI mannosyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_006522183.1

      UniProtKB/Swiss-Prot
      Q149K0, Q8BTP0
      Conserved Domains (1) summary
      cl21590
      Location:15406
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    3. XM_006522118.4XP_006522181.1  GPI mannosyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_006522181.1

      UniProtKB/Swiss-Prot
      Q149K0, Q8BTP0
      Conserved Domains (1) summary
      cl21590
      Location:15406
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase