Mtarc2 mitochondrial amidoxime reducing component 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtarc2provided by MGI
Official Full Name: mitochondrial amidoxime reducing component 2provided by MGI
Primary source: MGI:MGI:1914497
See related: Ensembl:ENSMUSG00000073481 AllianceGenome:MGI:1914497
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Marc2; Mosc2; mARC1; 2810484M10Rik
Summary: Predicted to enable molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Predicted to be involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion. Is expressed in cerebral cortex ventricular layer. Orthologous to human MTARC2 (mitochondrial amidoxime reducing component 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in duodenum adult (RPKM 313.8), small intestine adult (RPKM 139.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H5; 1 89.12 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (184545263..184579266, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (184813066..184846451, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Striking phenotypical features of MARC2 Knockout Mice mice were lower body weight, increased body temperature, decreased levels of total cholesterol, and increased glucose levels, supporting previous findings that MARC2 affects energy pathways.
Title: Mitochondrial amidoxime-reducing component 2 (MARC2) has a significant role in N-reductive activity and energy metabolism.
The presence of a novel reductive enzyme system of importance for lipid synthesis that is exclusively localized to the outer mitochondrial membrane and is composed of CYB5B, MOSC2, and a third unknown component (a CYB5B reductase).
Title: Amidoxime reductase system containing cytochrome b5 type B (CYB5B) and MOSC2 is of importance for lipid synthesis in adipocyte mitochondria.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molybdenum ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables molybdenum ion binding	IEA Inferred from Electronic Annotation more info
enables molybdenum ion binding	ISO Inferred from Sequence Orthology more info
enables molybdopterin cofactor binding	IBA Inferred from Biological aspect of Ancestor more info
enables molybdopterin cofactor binding	IEA Inferred from Electronic Annotation more info
enables molybdopterin cofactor binding	ISO Inferred from Sequence Orthology more info
enables nitrate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nitrate reductase activity	IEA Inferred from Electronic Annotation more info
enables nitrate reductase activity	ISO Inferred from Sequence Orthology more info
enables nitrite reductase activity	IEA Inferred from Electronic Annotation more info
enables nitrite reductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on other nitrogenous compounds as donors	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular detoxification of nitrogen compound	IEA Inferred from Electronic Annotation more info
involved_in cellular detoxification of nitrogen compound	ISO Inferred from Sequence Orthology more info
involved_in nitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nitrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nitrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial amidoxime reducing component 2

Names: MOCO sulphurase C-terminal domain containing 2; MOSC domain-containing protein 2, mitochondrial; moco sulfurase C-terminal domain-containing protein 2; molybdenum cofactor sulfurase C-terminal domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368285.1 → NP_001355214.1 mitochondrial amidoxime reducing component 2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC131992
NM_001368286.1 → NP_001355215.1 mitochondrial amidoxime reducing component 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC131992

Conserved Domains (1) summary

COG3217
Location:1 → 240

YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
NM_133684.4 → NP_598445.1 mitochondrial amidoxime reducing component 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_598445.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC131992

Consensus CDS

CCDS15594.1

UniProtKB/Swiss-Prot

Q922Q1

Related

ENSMUSP00000066715.4, ENSMUST00000068725.10

Conserved Domains (3) summary

COG3217
Location:56 → 333

YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]

pfam03473
Location:202 → 334

MOSC; MOSC domain

pfam03476
Location:54 → 175

MOSC_N; MOSC N-terminal beta barrel domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

184545263..184579266 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153109.1 → XP_036009002.1 mitochondrial amidoxime reducing component 2 isoform X1

Conserved Domains (1) summary

COG3217
Location:1 → 240

YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]