Aqp7 aquaporin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aqp7provided by MGI
Official Full Name: aquaporin 7provided by MGI
Primary source: MGI:MGI:1314647
See related: Ensembl:ENSMUSG00000028427 AllianceGenome:MGI:1314647
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AQP7L; AQPap
Summary: Predicted to enable glycerol channel activity; urea channel activity; and water channel activity. Acts upstream of or within glycerol transmembrane transport and renal water absorption. Located in plasma membrane. Colocalizes with lipid droplet. Is expressed in early conceptus; genitourinary system; inner ear; and liver. Orthologous to several human genes including AQP7 (aquaporin 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 55.7), subcutaneous fat pad adult (RPKM 41.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 20.83 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (41033074..41048237, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (41033074..41048237, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cardioprotective effect of St. Thomas' Hospital No. 2 solution against age-related changes in aquaporin-7-deficient mice.
Title: Cardioprotective effect of St. Thomas' Hospital No. 2 solution against age-related changes in aquaporin-7-deficient mice.
Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice.
Title: Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice.
Aquaporin 7 is upregulated through the PI3K-Akt pathway and modulates decidualisation of endometrial stromal cells.
Title: Aquaporin 7 is upregulated through the PI3K-Akt pathway and modulates decidualisation of endometrial stromal cells.
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Title: Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia.
Title: LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia.
Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer.
Title: Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer.
AQP7 and GLUT1 mRNA and protein have a higher expression in T1DM mice, but the levels of AQP9 mRNA and protein are not changed in the lung difference between normal and T1DM mice. T1DM may increase the expression of transporters of trivalent inorganic arsenic.
Title: Molecular mechanism of the increased tissue uptake of trivalent inorganic arsenic in mice with type 1 diabetes mellitus.
AQP-7 and -9 showed differential staining pattern in different stages of mouse estrus cycle. AQP-7 and -9-mediated glycerol transport in tanycyte cells might be under hormonal control to use glycerol as a potential energy substrate during mouse estrus cycle.
Title: Expression of aquaporin-7 and aquaporin-9 in tanycyte cells and choroid plexus during mouse estrus cycle.
upregulation of AQP7 plays an important role in improving of tolerance to hyperosmotic stress and survival of oocytes during cryopreservation by vitrification.
Title: Aquaporin7 plays a crucial role in tolerance to hyperosmotic stress and in the survival of oocytes during cryopreservation.
AQP7 is expressed in human and mouse oocytes and upregulated by cryoprotectants.
Title: Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (6) 1 citation

General gene information

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Markers

Aqp7 (e-PCR), detects polymorphism
- UniSTS:186496

Aqp7 (e-PCR), detects polymorphism
- UniSTS:209568

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycerol channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol channel activity	ISO Inferred from Sequence Orthology more info
enables glycerol channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables urea channel activity	ISO Inferred from Sequence Orthology more info
enables urea transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables urea transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables water channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in glycerol transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycerol transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glycerol transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within renal water absorption	IGI Inferred from Genetic Interaction more info	PubMed
involved_in urea transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in urea transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in water transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within water transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with lipid droplet	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aquaporin-7

Names: AQP-7; aquaglyceroporin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378638.1 → NP_001365567.1 aquaporin-7 isoform 1

Status: VALIDATED

Source sequence(s)

AL837521

Conserved Domains (1) summary

cl00200
Location:18 → 232

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_001378639.1 → NP_001365568.1 aquaporin-7 isoform 2

Status: VALIDATED

Source sequence(s)

AL837521

UniProtKB/Swiss-Prot

O54794, Q8C630

UniProtKB/TrEMBL

Q5DX24

Related

ENSMUSP00000093007.4, ENSMUST00000054945.8

Conserved Domains (1) summary

cl00200
Location:18 → 265

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_001378640.1 → NP_001365569.1 aquaporin-7 isoform 3

Status: VALIDATED

Source sequence(s)

AL837521

Conserved Domains (1) summary

cl00200
Location:44 → 202

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_001378641.1 → NP_001365570.1 aquaporin-7 isoform 4

Status: VALIDATED

Source sequence(s)

AL837521

Conserved Domains (1) summary

cl00200
Location:44 → 235

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_001378642.1 → NP_001365571.1 aquaporin-7 isoform 4

Status: VALIDATED

Source sequence(s)

AL837521

Conserved Domains (1) summary

cl00200
Location:44 → 235

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_007473.5 → NP_031499.1 aquaporin-7 isoform 2

See identical proteins and their annotated locations for NP_031499.1

Status: VALIDATED

Source sequence(s)

AL837521

Consensus CDS

CCDS18055.1

UniProtKB/Swiss-Prot

O54794, Q8C630

UniProtKB/TrEMBL

Q5DX24

Related

ENSMUSP00000030136.7, ENSMUST00000030136.13

Conserved Domains (1) summary

cl00200
Location:18 → 265

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

41033074..41048237 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537560.5 → XP_006537623.2 aquaporin-7 isoform X2

See identical proteins and their annotated locations for XP_006537623.2

UniProtKB/Swiss-Prot

O54794, Q8C630

UniProtKB/TrEMBL

Q5DX24

Conserved Domains (1) summary

cl00200
Location:18 → 265

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_006537559.5 → XP_006537622.2 aquaporin-7 isoform X1

See identical proteins and their annotated locations for XP_006537622.2

Conserved Domains (1) summary

cl00200
Location:18 → 232

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_006537563.2 → XP_006537626.1 aquaporin-7 isoform X1

See identical proteins and their annotated locations for XP_006537626.1

Conserved Domains (1) summary

cl00200
Location:18 → 232

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_030253099.2 → XP_030108959.1 aquaporin-7 isoform X1

Conserved Domains (1) summary

cl00200
Location:18 → 232

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_036163606.1 → XP_036019499.1 aquaporin-7 isoform X3

Conserved Domains (1) summary

cl00200
Location:20 → 179

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_017319925.2 → XP_017175414.1 aquaporin-7 isoform X4