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    Fmo5 flavin containing monooxygenase 5 [ Mus musculus (house mouse) ]

    Gene ID: 14263, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fmo5provided by MGI
    Official Full Name
    flavin containing monooxygenase 5provided by MGI
    Primary source
    MGI:MGI:1310004
    See related
    Ensembl:ENSMUSG00000028088 AllianceGenome:MGI:1310004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5033418D19Rik
    Summary
    Predicted to enable N,N-dimethylaniline monooxygenase activity and aldehyde oxidase activity. Involved in regulation of cholesterol metabolic process. Predicted to be located in cytosol and endoplasmic reticulum. Is expressed in bladder. Orthologous to human FMO5 (flavin containing dimethylaniline monoxygenase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 151.5), liver adult (RPKM 23.9) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Fmo5 in Genome Data Viewer
    Location:
    3 F2.2; 3 42.23 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97517248..97562603)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (97609938..97655287)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 13 subfamily L member 2 Neighboring gene STARR-seq mESC enhancer starr_08465 Neighboring gene STARR-seq mESC enhancer starr_08467 Neighboring gene STARR-seq mESC enhancer starr_08468 Neighboring gene predicted gene, 40102 Neighboring gene chromodomain helicase DNA binding protein 1-like Neighboring gene STARR-positive B cell enhancer ABC_E9010 Neighboring gene protein kinase, AMP-activated, beta 2 non-catalytic subunit Neighboring gene nuclear encoded tRNA glutamine 2 (anticodon CTG) Neighboring gene predicted gene, 31242

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism. Phillips IR, et al. PLoS One, 2023. PMID 37267233, Free PMC Article
    2. pH dependence on functional activity of human and mouse flavin-containing monooxygenase 5. Motika MS, et al. Biochem Pharmacol, 2012 Apr 1. PMID 22266355
    3. Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice. Varshavi D, et al. Front Mol Biosci, 2018. PMID 29686991, Free PMC Article
    4. Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis. Veeravalli S, et al. Drug Metab Dispos, 2018 Jan. PMID 29070510, Free PMC Article
    5. Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria. Scott F, et al. Drug Metab Dispos, 2017 Sep. PMID 28646079, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism.
      Title: Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism.
    2. Hepatic Fmo5 displayed diurnal rhythmicities in expression and activity in mice.
      Title: The Molecular Mechanism Regulating Diurnal Rhythm of Flavin-Containing Monooxygenase 5 in Mouse Liver.
    3. Fmo5(-)(/)(-) mice have metabolic characteristics similar to those of germ-free mice, indicating that FMO5 plays a role in sensing or responding to gut bacteria. In WT mice, FMO5 is present in the mucosal epithelium of the gastrointestinal tract where it is induced in response to a high-fat diet.
      Title: Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria.
    4. The phenotype of a knockout mouse identifies FMO5 as a regulator of metabolic aging.
      Title: The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing.
    5. The functional activity of Fmo5 was determined.
      Title: Functional activity of the mouse flavin-containing monooxygenase forms 1, 3, and 5.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH oxidase H202-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldehyde oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADPH oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    flavin-containing monooxygenase 5
    Names
    NADPH oxidase
    NAPDH oxidase
    dimethylaniline monooxygenase [N-oxide-forming] 5
    dimethylaniline oxidase 5
    hepatic flavin-containing monooxygenase 5
    NP_001155235.1
    NP_001155237.1
    NP_001342048.1
    NP_034362.2
    XP_006501058.1
    XP_006501059.1
    XP_011238315.1
    XP_030108278.1
    XP_030108279.1
    XP_030108280.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161763.1 → NP_001155235.1  flavin-containing monooxygenase 5 isoform 1

      See identical proteins and their annotated locations for NP_001155235.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC130541, AK133675, AK162951
      Consensus CDS
      CCDS17656.1
      UniProtKB/Swiss-Prot
      P97872, Q8R1W6
      Related
      ENSMUSP00000102665.2, ENSMUST00000107050.8
      Conserved Domains (1) summary
      pfam00743
      Location:3 → 532
      FMO-like; Flavin-binding monooxygenase-like

    2. NM_001161765.1 → NP_001155237.1  flavin-containing monooxygenase 5 isoform 1

      See identical proteins and their annotated locations for NP_001155237.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC130541, AC140839, AK133675
      Consensus CDS
      CCDS17656.1
      UniProtKB/Swiss-Prot
      P97872, Q8R1W6
      Related
      ENSMUSP00000102664.2, ENSMUST00000107049.2
      Conserved Domains (1) summary
      pfam00743
      Location:3 → 532
      FMO-like; Flavin-binding monooxygenase-like

    3. NM_001355119.1 → NP_001342048.1  flavin-containing monooxygenase 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130541, AC140839
      Conserved Domains (1) summary
      pfam00743
      Location:1 → 466
      FMO-like; Flavin-binding monooxygenase-like

    4. NM_010232.5 → NP_034362.2  flavin-containing monooxygenase 5 isoform 1

      See identical proteins and their annotated locations for NP_034362.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC130541, AK133675, AK162951, CN664821
      Consensus CDS
      CCDS17656.1
      UniProtKB/Swiss-Prot
      P97872, Q8R1W6
      Related
      ENSMUSP00000029729.9, ENSMUST00000029729.15
      Conserved Domains (1) summary
      pfam00743
      Location:3 → 532
      FMO-like; Flavin-binding monooxygenase-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      97517248..97562603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500995.5 → XP_006501058.1  flavin-containing monooxygenase 5 isoform X1

      See identical proteins and their annotated locations for XP_006501058.1

      UniProtKB/Swiss-Prot
      P97872, Q8R1W6
      Conserved Domains (1) summary
      pfam00743
      Location:3 → 532
      FMO-like; Flavin-binding monooxygenase-like

    2. XM_030252419.1 → XP_030108279.1  flavin-containing monooxygenase 5 isoform X3

      Conserved Domains (1) summary
      pfam00743
      Location:3 → 397
      FMO-like; Flavin-binding monooxygenase-like

    3. XM_030252420.1 → XP_030108280.1  flavin-containing monooxygenase 5 isoform X3

      Conserved Domains (1) summary
      pfam00743
      Location:3 → 397
      FMO-like; Flavin-binding monooxygenase-like

    4. XM_011240013.3 → XP_011238315.1  flavin-containing monooxygenase 5 isoform X3

      Conserved Domains (1) summary
      pfam00743
      Location:3 → 397
      FMO-like; Flavin-binding monooxygenase-like

    5. XM_030252418.1 → XP_030108278.1  flavin-containing monooxygenase 5 isoform X2

      Conserved Domains (1) summary
      pfam00743
      Location:1 → 466
      FMO-like; Flavin-binding monooxygenase-like

    6. XM_006500996.2 → XP_006501059.1  flavin-containing monooxygenase 5 isoform X2

      See identical proteins and their annotated locations for XP_006501059.1

      Conserved Domains (1) summary
      pfam00743
      Location:1 → 466
      FMO-like; Flavin-binding monooxygenase-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97872.4 GenPept UniProtKB/Swiss-Prot:P97872

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