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    Eif1a eukaryotic translation initiation factor 1A [ Mus musculus (house mouse) ]

    Gene ID: 13664, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Eif1aprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 1Aprovided by MGI
    Primary source
    MGI:MGI:95298
    See related
    Ensembl:ENSMUSG00000057561 AllianceGenome:MGI:95298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ef1a; Eftu; Eif4c; eIF-1A; eIF-4C
    Summary
    Predicted to enable ribosomal large subunit binding activity and translation initiation factor activity. Predicted to be involved in ribosome assembly and translational initiation. Predicted to be part of eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and multi-eIF complex. Predicted to be active in cytoplasm. Is expressed in several structures, including early conceptus; gonad; liver; lung; and spleen. Orthologous to human EIF1AX (eukaryotic translation initiation factor 1A X-linked). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 35.4), bladder adult (RPKM 15.3) and 28 other tissues See more
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    Genomic context

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    See Eif1a in Genome Data Viewer
    Location:
    18 C; 18 24.68 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (46730771..46743292)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46597704..46610225)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RAD51 homolog c pseudogene Neighboring gene transmembrane p24 trafficking protein 7 Neighboring gene predicted gene 3734 Neighboring gene STARR-seq mESC enhancer starr_44514 Neighboring gene predicted gene, 54021

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Real-time reverse transcription-polymerase chain reaction analysis of translation initiation factor 1A (eIF-1A) in human and mouse preimplantation embryos. Lindeberg M, et al. Reprod Biomed Online, 2004 Mar. PMID 15038901
    2. Transient expression of translation initiation factor eIF-4C during the 2-cell stage of the preimplantation mouse embryo: identification by mRNA differential display and the role of DNA replication in zygotic gene activation. Davis W Jr, et al. Dev Biol, 1996 Mar 15. PMID 8631492
    3. Mapping of the eukaryotic initiation factor eIF-1A gene, Eif1a, to mouse chromosome 12D-E by FISH. Kikyo N, et al. Mamm Genome, 1997 May. PMID 9107689
    4. Molecular cloning and expression of the mouse translation initiation factor eIF-1A. Davis W Jr, et al. Nucleic Acids Res, 1998 Oct 15. PMID 9753744, Free PMC Article
    5. The complete cDNA sequence of mouse elongation factor 1 alpha (EF 1 alpha) mRNA. Lu XA, et al. Nucleic Acids Res, 1989 Jan 11. PMID 2911475, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear-localized eukaryotic translation initiation factor 1A is involved in mouse preimplantation embryo development.
      Title: Nuclear-localized eukaryotic translation initiation factor 1A is involved in mouse preimplantation embryo development.
    2. Imp13 is able to bind and export eIF1A in vivo and that its function is essential.
      Title: Structural basis for the nuclear export activity of Importin13.
    3. Inhibiting the first round increased the expression levels of hsp70.1, eif-1a and zscan4d but decreased that of muerv, while inhibiting the second round increased the expression levels of all four genes.
      Title: Roles of the first and second round of DNA replication in the regulation of zygotic gene activation in mice.
    4. mGluR-LTD was associated with increased synthesis of the 5'TOP-encoded protein elongation factor 1A (EF1A).
      Title: mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice.
    5. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
      Title: Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribosomal large subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 43S preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic 48S preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of multi-eIF complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 1A
    Names
    eukaryotic translation initiation factor 4C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374654.1 → NP_001361583.1  eukaryotic translation initiation factor 1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127342
      UniProtKB/TrEMBL
      A0A494BB95
      Related
      ENSMUSP00000158417.2, ENSMUST00000237478.2
      Conserved Domains (1) summary
      PTZ00329
      Location:111 → 241
      PTZ00329; eukaryotic translation initiation factor 1A; Provisional

    2. NM_010120.5 → NP_034250.3  eukaryotic translation initiation factor 1A isoform 2

      See identical proteins and their annotated locations for NP_034250.3

      Status: VALIDATED

      Source sequence(s)
      AK013268, AK019451, AK150673, CN722607
      Consensus CDS
      CCDS29233.1
      UniProtKB/Swiss-Prot
      O88847, Q60872, Q8R2M4, Q9CX76, Q9DB61
      UniProtKB/TrEMBL
      Q3UC76, Q4FJR7
      Related
      ENSMUSP00000077223.4, ENSMUST00000078079.11
      Conserved Domains (1) summary
      PTZ00329
      Location:1 → 131
      PTZ00329; eukaryotic translation initiation factor 1A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      46730771..46743292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60872.3 GenPept UniProtKB/Swiss-Prot:Q60872

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