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    Dhrs7 dehydrogenase/reductase 7 [ Mus musculus (house mouse) ]

    Gene ID: 66375, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dhrs7provided by MGI
    Official Full Name
    dehydrogenase/reductase 7provided by MGI
    Primary source
    MGI:MGI:1913625
    See related
    Ensembl:ENSMUSG00000021094 AllianceGenome:MGI:1913625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Retdsr4; Retsdr4; 2310016E22Rik; 5730564L20Rik
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity and carbonyl reductase (NADPH) activity. Predicted to be involved in retinol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in diencephalon; heart and pericardium; and lower jaw alveolar sulcus. Orthologous to human DHRS7 (dehydrogenase/reductase 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 43.7), mammary gland adult (RPKM 34.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhrs7 in Genome Data Viewer
    Location:
    12 C3; 12 30.23 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (72697127..72711678, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (72650353..72664828, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene pecanex homolog 4 Neighboring gene STARR-seq mESC enhancer starr_32441 Neighboring gene lymphocyte antigen 6 family member E, pseudogene 1 Neighboring gene dehydrogenase/reductase 7 like 1 Neighboring gene STARR-seq mESC enhancer starr_32442 Neighboring gene STARR-seq mESC enhancer starr_32443 Neighboring gene STARR-seq mESC enhancer starr_32444 Neighboring gene STARR-seq mESC enhancer starr_32445 Neighboring gene STARR-seq mESC enhancer starr_32447 Neighboring gene STARR-seq mESC enhancer starr_32449 Neighboring gene STARR-seq mESC enhancer starr_32450 Neighboring gene protein phosphatase 1A, magnesium dependent, alpha isoform Neighboring gene predicted gene, 33785

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus. Rattner A, et al. Elife, 2020 Oct 21. PMID 33084572, Free PMC Article
    2. Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4. Velecela V, et al. Development, 2019 Oct 17. PMID 31624071
    3. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. Dai FF, et al. J Biol Chem, 2015 Oct 9. PMID 26272612, Free PMC Article
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbonyl reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbonyl reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 7
    Names
    dehydrogenase/reductase (SDR family) member 7
    retinal short-chain dehydrogenase/reductase 4
    short chain dehydrogenase/reductase family 34C member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025522.5 → NP_079798.2  dehydrogenase/reductase SDR family member 7 precursor

      See identical proteins and their annotated locations for NP_079798.2

      Status: VALIDATED

      Source sequence(s)
      AK014100, CF586466, CX223953
      Consensus CDS
      CCDS49086.1
      UniProtKB/Swiss-Prot
      Q9CXR1
      UniProtKB/TrEMBL
      A0A1Y7VN19
      Related
      ENSMUSP00000021512.10, ENSMUST00000021512.11
      Conserved Domains (1) summary
      cd05332
      Location:48 → 308
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      72697127..72711678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157560.1 → XP_036013453.1  dehydrogenase/reductase SDR family member 7 isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VN19
      Conserved Domains (1) summary
      cd05332
      Location:29 → 289
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXR1.2 GenPept UniProtKB/Swiss-Prot:Q9CXR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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