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    Pcyt1b phosphate cytidylyltransferase 1, choline, beta isoform [ Mus musculus (house mouse) ]

    Gene ID: 236899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcyt1bprovided by MGI
    Official Full Name
    phosphate cytidylyltransferase 1, choline, beta isoformprovided by MGI
    Primary source
    MGI:MGI:2147987
    See related
    Ensembl:ENSMUSG00000035246 AllianceGenome:MGI:2147987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CTTbeta
    Summary
    Enables choline-phosphate cytidylyltransferase activity. Involved in CDP-choline pathway. Acts upstream of or within ovarian follicle development and spermatogenesis. Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; nervous system; and sensory organ. Orthologous to human PCYT1B (phosphate cytidylyltransferase 1B, choline). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 9.3), CNS E14 (RPKM 7.0) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcyt1b in Genome Data Viewer
    Location:
    X C3; X 41.28 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (92698469..92793557)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (93654863..93749951)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), alpha 1 Neighboring gene predicted gene, 23557 Neighboring gene STARR-seq mESC enhancer starr_47550 Neighboring gene STARR-seq mESC enhancer starr_47551 Neighboring gene predicted pseudogene 6985 Neighboring gene predicted gene, 35641 Neighboring gene pyruvate dehydrogenase kinase, isoenzyme 3 Neighboring gene SPT20 SAGA complex component, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets. Ogasawara Y, et al. Nat Commun, 2020 Sep 8. PMID 32900992, Free PMC Article
    2. Involvement of CTP:phosphocholine cytidylyltransferase-β2 in axonal phosphatidylcholine synthesis and branching of neurons. Strakova J, et al. Biochim Biophys Acta, 2011 Oct. PMID 21736954
    3. Probucol therapy overcomes the reproductive defect in CTP: phosphocholine cytidylyltransferase beta2 knockout mice. Gunter C, et al. Biochim Biophys Acta, 2007 Jul. PMID 17560827, Free PMC Article
    4. Characterization of the murine CTP:phosphocholine cytidylyltransferase beta gene promoter. Marcucci H, et al. Biochim Biophys Acta, 2008 May. PMID 18423385
    5. Disruption of CCTbeta2 expression leads to gonadal dysfunction. Jackowski S, et al. Mol Cell Biol, 2004 Jun. PMID 15143167, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long-term autophagy is sustained by activation of CCTbeta3 on lipid droplets.
      Title: Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets.
    2. Results suggest that the activities of alternative promoters provide for greater flexibility in the control of CTP:phosphocholine cytidylyltransferase beta isoform expression.
      Title: Characterization of the murine CTP:phosphocholine cytidylyltransferase beta gene promoter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables choline-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables choline-phosphate cytidylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CDP-choline pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    choline-phosphate cytidylyltransferase B
    Names
    CCT B
    CCT-beta
    CT B
    CTP:phosphocholine cytidylyltransferase B
    phosphorylcholine transferase B
    NP_808214.1
    NP_997593.1
    XP_006528048.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177546.2 → NP_808214.1  choline-phosphate cytidylyltransferase B isoform 2

      See identical proteins and their annotated locations for NP_808214.1

      Status: VALIDATED

      Source sequence(s)
      AK032027, BB642464
      Consensus CDS
      CCDS41061.1
      UniProtKB/Swiss-Prot
      Q811Q9
      Related
      ENSMUSP00000109566.3, ENSMUST00000113933.9
      Conserved Domains (1) summary
      PLN02413
      Location:42 → 263
      PLN02413; choline-phosphate cytidylyltransferase

    2. NM_211138.1 → NP_997593.1  choline-phosphate cytidylyltransferase B isoform 1

      See identical proteins and their annotated locations for NP_997593.1

      Status: VALIDATED

      Source sequence(s)
      AK032027, BB646993
      Consensus CDS
      CCDS30274.1
      UniProtKB/Swiss-Prot
      Q3UEW0, Q80Y63, Q811Q8, Q811Q9, Q8BKD2, Q8C085
      Related
      ENSMUSP00000044280.4, ENSMUST00000045898.4
      Conserved Domains (1) summary
      cl28626
      Location:72 → 314
      PLN02406; ethanolamine-phosphate cytidylyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      92698469..92793557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527985.5 → XP_006528048.1  choline-phosphate cytidylyltransferase B isoform X1

      Conserved Domains (1) summary
      PLN02413
      Location:52 → 294
      PLN02413; choline-phosphate cytidylyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q811Q9.2 GenPept UniProtKB/Swiss-Prot:Q811Q9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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