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    Sel1l2 sel-1 suppressor of lin-12-like 2 (C. elegans) [ Mus musculus (house mouse) ]

    Gene ID: 228684, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sel1l2provided by MGI
    Official Full Name
    sel-1 suppressor of lin-12-like 2 (C. elegans)provided by MGI
    Primary source
    MGI:MGI:2684964
    See related
    Ensembl:ENSMUSG00000074764 AllianceGenome:MGI:2684964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm118
    Summary
    Predicted to be involved in ERAD pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SEL1L2 (SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 8.6) See more
    Orthologs
    human all
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    Genomic context

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    See Sel1l2 in Genome Data Viewer
    Location:
    2 F3; 2 69.2 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (140071519..140231644, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (140229599..140389710, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139996213-139996396 Neighboring gene STARR-seq mESC enhancer starr_05846 Neighboring gene STARR-seq mESC enhancer starr_05847 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 5 Neighboring gene predicted gene, 52594 Neighboring gene ESF1 nucleolar pre-rRNA processing protein homolog Neighboring gene STARR-positive B cell enhancer mm9_chr2:140253034-140253335 Neighboring gene STARR-seq mESC enhancer starr_05848 Neighboring gene STARR-seq mESC enhancer starr_05850 Neighboring gene mono-ADP ribosylhydrolase 2 Neighboring gene predicted gene, 23846 Neighboring gene STARR-seq mESC enhancer starr_05851 Neighboring gene fibronectin leucine rich transmembrane protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein sel-1 homolog 2
    Names
    sel-1L2
    suppressor of lin-12-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033296.3 → NP_001028468.1  protein sel-1 homolog 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001028468.1

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL844528
      Consensus CDS
      CCDS50732.1
      UniProtKB/Swiss-Prot
      A2AHP5, B0QZY0, Q3V172
      UniProtKB/TrEMBL
      B9EKJ8
      Related
      ENSMUSP00000113800.2, ENSMUST00000122367.8
      Conserved Domains (3) summary
      smart00671
      Location:407 → 441
      SEL1; Sel1-like repeats
      COG0790
      Location:349 → 625
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:317 → 346
      SLR; SLR repeat [structural motif]

    2. NM_001418964.1 → NP_001405893.1  protein sel-1 homolog 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL731795
      UniProtKB/TrEMBL
      B0QZY1
      Related
      ENSMUSP00000112724.2, ENSMUST00000120133.2

    RNA

    1. NR_184864.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL731795, AL844528

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      140071519..140231644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317771.2 → XP_017173260.2  protein sel-1 homolog 2 isoform X1

      UniProtKB/TrEMBL
      B9EKJ8
      Conserved Domains (2) summary
      COG0790
      Location:349 → 625
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:317 → 346
      SLR; SLR repeat [structural motif]

    2. XM_030250523.2 → XP_030106383.1  protein sel-1 homolog 2 isoform X3

      Conserved Domains (2) summary
      COG0790
      Location:183 → 459
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:151 → 180
      SLR; SLR repeat [structural motif]

    3. XM_030250522.2 → XP_030106382.2  protein sel-1 homolog 2 isoform X2

      UniProtKB/TrEMBL
      B9EKJ8
      Conserved Domains (2) summary
      COG0790
      Location:349 → 625
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:317 → 346
      SLR; SLR repeat [structural motif]

    RNA

    1. XR_004940111.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V172.1 GenPept UniProtKB/Swiss-Prot:Q3V172

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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