Traf2 TNF receptor-associated factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Traf2provided by MGI
Official Full Name: TNF receptor-associated factor 2provided by MGI
Primary source: MGI:MGI:101835
See related: Ensembl:ENSMUSG00000026942 AllianceGenome:MGI:101835
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables CD40 receptor binding activity; signaling adaptor activity; and ubiquitin protein ligase activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to nitric oxide; regulation of JNK cascade; and regulation of immunoglobulin production. Located in several cellular components, including cytoplasmic side of plasma membrane; membrane raft; and vesicle membrane. Part of CD40 receptor complex and IRE1-TRAF2-ASK1 complex. Is expressed in several structures, including genitourinary system; liver; lower jaw tooth; and mandibular process. Orthologous to human TRAF2 (TNF receptor associated factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 9.5), spleen adult (RPKM 6.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.32 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25407994..25436952, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25517982..25546940, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAF2 decrease promotes the TGF-beta-mTORC1 signal in MAFLD-HCC through enhancing AXIN1-mediated Smad7 degradation.
Title: TRAF2 decrease promotes the TGF-β-mTORC1 signal in MAFLD-HCC through enhancing AXIN1-mediated Smad7 degradation.
TRAF2 inhibits senescence in hepatocellular carcinoma cells via regulating the ROMO1/ NAD[+]/SIRT3/SOD2 axis.
Title: TRAF2 inhibits senescence in hepatocellular carcinoma cells via regulating the ROMO1/ NAD(+)/SIRT3/SOD2 axis.
Silencing of CPNE1-TRAF2 Axis Restrains the Development of Pancreatic Cancer.
Title: Silencing of CPNE1-TRAF2 Axis Restrains the Development of Pancreatic Cancer.
The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
Title: The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway.
Title: Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway.
TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2.
Title: TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2.
TRAF2 Ser-11 Phosphorylation Promotes Cytosolic Translocation of the CD40 Complex To Regulate Downstream Signaling Pathways.
Title: TRAF2 Ser-11 Phosphorylation Promotes Cytosolic Translocation of the CD40 Complex To Regulate Downstream Signaling Pathways.
The GSK3beta regulates Src phosphorylation via TNFR-associated factor 2 (TRAF2)-mediated Src ubiquitination.
Title: Glycogen Synthase Kinase 3β Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis.
Striatal knockdown of TRAF2 increased infarction size, cell death, microglial activation and the expression of pro-inflammatory markers at 24 h after reperfusion. TRAF2 expression and necroptosis were induced in mouse primary microglia treated with conditioned medium collected from neurons subject to oxygen and glucose deprivation.
Title: TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis.
Study findings demonstrate that RelB, involved in noncanonical NF-kappaB signaling, is upregulated by TRAF2 and is required for mediating the cytoprotective effects of TRAF2 overexpression in mouse model of myocardial infarction. Cytoprotective effects of TRAF2 are mediated by crosstalk between the canonical and noncanonical NF-kappaB signaling pathways, thereby revealing a complexity for NF-kappaB signaling in the heart.
Title: TNF receptor-activated factor 2 mediates cardiac protection through noncanonical NF-κB signaling.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

UniSTS:224846 (e-PCR)
- UniSTS:224846

AI325259 (e-PCR)
- UniSTS:178587

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CD40 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables sphingolipid binding	ISO Inferred from Sequence Orthology more info
enables sphingolipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables thioesterase binding	IEA Inferred from Electronic Annotation more info
enables thioesterase binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor binding	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CD27 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in CD40 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in T cell activation	IEA Inferred from Electronic Annotation more info
involved_in TORC1 complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in TORC2 complex disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to nitric oxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect innate immune response	ISO Inferred from Sequence Orthology more info
involved_in interleukin-17-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-17-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of glial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within programmed necrotic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein K63-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction involved in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction involved in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of CD40 receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of IRE1-TRAF2-ASK1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of IRE1-TRAF2-ASK1 complex	ISO Inferred from Sequence Orthology more info
part_of TRAF2-GSTP1 complex	IEA Inferred from Electronic Annotation more info
part_of TRAF2-GSTP1 complex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
part_of plasma membrane signaling receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of tumor necrosis factor receptor superfamily complex	IEA Inferred from Electronic Annotation more info
part_of tumor necrosis factor receptor superfamily complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TNF receptor-associated factor 2

Names: E3 ubiquitin-protein ligase TRAF2; RING-type E3 ubiquitin transferase TRAF2

NP_001277342.1

EC 2.3.2.27

NP_033448.2

EC 2.3.2.27

XP_006497912.1

EC 2.3.2.27

XP_006497913.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290413.1 → NP_001277342.1 TNF receptor-associated factor 2 isoform a

See identical proteins and their annotated locations for NP_001277342.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AF027570, AK052934, BB841262

Consensus CDS

CCDS71002.1

UniProtKB/TrEMBL

Q8C6X9, Q8CAQ7

Related

ENSMUSP00000109872.2, ENSMUST00000114234.2

Conserved Domains (4) summary

cd03778
Location:341 → 504

MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:185 → 242

zf-TRAF; TRAF-type zinc finger

cd16639
Location:32 → 80

RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins

pfam16673
Location:276 → 336

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
NM_009422.3 → NP_033448.2 TNF receptor-associated factor 2 isoform b

See identical proteins and their annotated locations for NP_033448.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AK052934, AK152174, BB841262

Consensus CDS

CCDS15779.1

UniProtKB/Swiss-Prot

A2AJA3, O54896, P39429

UniProtKB/TrEMBL

Q3U8L1, Q8C6X9, Q8CAQ7

Related

ENSMUSP00000028311.7, ENSMUST00000028311.13

Conserved Domains (4) summary

cd03778
Location:334 → 497

MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam00097
Location:34 → 72

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam02176
Location:178 → 235

zf-TRAF; TRAF-type zinc finger

pfam16673
Location:267 → 329

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

25407994..25436952 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497850.2 → XP_006497913.1 TNF receptor-associated factor 2 isoform X2

Conserved Domains (3) summary

cd03778
Location:303 → 466

MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:147 → 204

zf-TRAF; TRAF-type zinc finger

pfam16673
Location:236 → 298

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_006497849.2 → XP_006497912.1 TNF receptor-associated factor 2 isoform X1

UniProtKB/TrEMBL

Q8CAQ7

Conserved Domains (3) summary

cd03778
Location:336 → 499

MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:180 → 237

zf-TRAF; TRAF-type zinc finger

pfam16673
Location:269 → 331

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain