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    Ccser2 coiled-coil serine rich 2 [ Mus musculus (house mouse) ]

    Gene ID: 72972, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ccser2provided by MGI
    Official Full Name
    coiled-coil serine rich 2provided by MGI
    Primary source
    MGI:MGI:101859
    See related
    Ensembl:ENSMUSG00000058690 AllianceGenome:MGI:101859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcap14; Fam190b; 1700012P13Rik; 2900054P12Rik
    Summary
    Enables microtubule binding activity. Acts upstream of or within microtubule bundle formation. Located in microtubule cytoskeleton. Is expressed in several structures, including brain; cranial ganglion; dorsal root ganglion; sensory organ; and thymus primordium. Orthologous to human CCSER2 (coiled-coil serine rich protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 16.1), kidney adult (RPKM 14.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccser2 in Genome Data Viewer
    Location:
    14 B; 14 21.29 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (36596893..36690762, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (36874936..36968841, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene SET translocation pseudogene Neighboring gene STARR-seq mESC enhancer starr_36414 Neighboring gene predicted gene, 25204 Neighboring gene STARR-positive B cell enhancer ABC_E3109 Neighboring gene STARR-seq mESC enhancer starr_36416 Neighboring gene predicted gene, 53853 Neighboring gene STARR-seq mESC enhancer starr_36418 Neighboring gene STARR-positive B cell enhancer ABC_E8553 Neighboring gene STARR-seq mESC enhancer starr_36421 Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 Neighboring gene retinal G protein coupled receptor Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The murine Gcap14 gene encodes a novel microtubule binding and bundling protein. Hosono H, et al. FEBS Lett, 2012 May 21. PMID 22673506
    2. Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment. Mun DJ, et al. Proc Natl Acad Sci U S A, 2023 Feb 21. PMID 36795749, Free PMC Article
    3. Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Kambouris M, et al. Brain Res Mol Brain Res, 1994 Sep. PMID 7808216
    4. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment.
      Title: Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine-rich coiled-coil domain-containing protein 2
    Names
    coiled-coil serine-rich protein 2
    granule cell antiserum positive 14
    granule cell antiserum positive protein 14
    protein FAM190B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347502.1 → NP_001334431.1  serine-rich coiled-coil domain-containing protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and shorter 3' UTR. The encoded protein (isoform 2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK147383, BC111465, BM214039
      Consensus CDS
      CCDS84113.1
      UniProtKB/Swiss-Prot
      Q3UHI0

    2. NM_001347503.1 → NP_001334432.1  serine-rich coiled-coil domain-containing protein 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154655, AK147383, BM214039, CJ103616, CV556741
      Consensus CDS
      CCDS84112.1
      UniProtKB/TrEMBL
      S4R211, S4R2U3
      Related
      ENSMUSP00000138453.2, ENSMUST00000182042.2

    3. NM_027045.1 → NP_081321.1  serine-rich coiled-coil domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_081321.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK147383, BB871809, BM214039, CV556741
      Consensus CDS
      CCDS26948.1
      UniProtKB/Swiss-Prot
      B2RT11, Q2NKY3, Q3TA20, Q3UHI0, Q6ZPX3, Q9DAD5
      Related
      ENSMUSP00000087478.4, ENSMUST00000090024.11

    4. NM_028407.4 → NP_082683.2  serine-rich coiled-coil domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_082683.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different 5' UTR segment, uses a downstream start codon, and lacks a segment in the 3' coding region, compared to variant 1. These changes result in a frameshift. The encoded protein (isoform 2) has a shorter N-terminus and a distinct C-terminus when compared to isoform 1.
      Source sequence(s)
      AC154655, AC158525
      Consensus CDS
      CCDS26947.1
      UniProtKB/TrEMBL
      A0A0R4J2A7
      Related
      ENSMUSP00000138718.2, ENSMUST00000183038.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      36596893..36690762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248048.2 → XP_030103908.1  serine-rich coiled-coil domain-containing protein 2 isoform X2

      Related
      ENSMUSP00000068550.7, ENSMUST00000067700.13

    2. XM_006519606.5 → XP_006519669.1  serine-rich coiled-coil domain-containing protein 2 isoform X5

    3. XM_006519605.4 → XP_006519668.1  serine-rich coiled-coil domain-containing protein 2 isoform X4

    4. XM_011245208.4 → XP_011243510.1  serine-rich coiled-coil domain-containing protein 2 isoform X3

    5. XM_036158858.1 → XP_036014751.1  serine-rich coiled-coil domain-containing protein 2 isoform X1

    6. XM_036158860.1 → XP_036014753.1  serine-rich coiled-coil domain-containing protein 2 isoform X7

    7. XM_006519607.3 → XP_006519670.1  serine-rich coiled-coil domain-containing protein 2 isoform X9

    8. XM_036158861.1 → XP_036014754.1  serine-rich coiled-coil domain-containing protein 2 isoform X8

    9. XM_036158863.1 → XP_036014756.1  serine-rich coiled-coil domain-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      S4R211, S4R2U3

    10. XM_036158862.1 → XP_036014755.1  serine-rich coiled-coil domain-containing protein 2 isoform X8

    11. XM_036158859.1 → XP_036014752.1  serine-rich coiled-coil domain-containing protein 2 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHI0.1 GenPept UniProtKB/Swiss-Prot:Q3UHI0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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